Coronavirus Remedies - Chloroquine and Herbal Medicines

- by Peter Myers

Date: March 27, 2020; update April 24, 2020

My comments are shown {thus}; write to me at contact.html.

You are at http://mailstar.net/coronavirus-remedies.html .

My other pages on the Coronavirus are:

Coronavirus was developed in a Wuhan lab as a BioWeapon: coronavirus.html .

Helicopter money: Central Banks should directly fund government deficits: coronavirus-finance.html .

New material is added at the bottom; you might like to check now and then.

(1) Prophylacytic Dosage of Chloroquine or Hydroxychloroquine, from the Government of India
(2) Two common drugs, Chloroquine and Kaletra, found to kill Coronavirus; but CDC & FDA bureaucrats want to delay
(3) Australian Coronavirus patients cured with Chloroquine (Malaria drug) or Kaletra (HIV drug); no unexpected side effects
(4) Drug companies prepare to deliver tens of millions of Chloroquine tablets (a cheap and a safe drug); FDA hesitant
(5) CNN Fact Check says 'Chloroquine has not been approved by the FDA to treat the coronavirus'
(6) Kaletra (HIV drug) and Chloroquine: Australian researchers claim two existing drugs could 'cure' COVID-19
(7) FDA statement: no, these drugs are not approved as treatments for COVID-19
(8) Is it ok to use a drug that's not yet certified? Bureaucrats Fiddle while Rome burns
(9) Hydroxychloroquine (HCQ) less effective than Chloroquine (CQ) in inhibiting SARS-CoV-2; thanks to Zhengli Shi
(10) Hospitals are not waiting for FDA bureaucrats: Chloroquine in short supply as hospitals buy in bulk
(11) Military personnel given Flu vaccine were significantly more susceptible to Coronavirus
(12) French Peer-Reviewed Study: Didier Raoult announces Cure for Coronavirus: HCQ + Azithromycin
(13) Economist endorses CQ HCQ & Kaletra cures for COVID-19, because 'Medicines designed to treat COVID-19 won't be on pharmacy shelves for months or even years'
(14) NYT dismisses chloroquine cure for COVID-19
(15) Olive Leaf ingredient oleuropein acts as an antiviral agent
(16) Ole and HT may be useful against other viruses ... including severe acute respiratory syndrome associated coronavirus
(17) Urology site endorses natural treatment: How Viruses Work and How to Prevent and Eliminate Them
(18) CQ and HCQ are zinc ionophores, i.e., carriers of zinc ions into the lung cell's interior; Quercetin dies the same, and it can be purchased over-the-counter
(19) Dr. Vladimir Zelenko successfully treats Hasidic Jewish patients with HCQ, no need to go to Hospital
(20) CDC knew Chloroquine effective against Coronavirus since 2005; Class Action against CDC
(21) Vladimir Zelenko's success is a setback for CDC, MSM & Big Pharma which is developing a multibillion dollar vaccination program
(22) Peer-reviewed study of 2005 attests that Chloroquine inhibits SARS CoV
(23) Herbal remedies for Coronavirus: Quercetin, Coconut oil, Cinnamon, Ginger, Sage, Rosemary
(24) Philippines study of Virgin Coconut Oil as remedy for COVID-19
(25) Nevada prohibits prescribing CQ HCQ
(26) Quercetin, Inflammation and Immunity
(27) Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry
(28) Quercetin is a plant pigment (flavonoid) found in brightly-coloured fruits & veg
(29) Ministry of Truth (Globalist MSM) brand Didier Raoult's Chloroquine cure 'Fake News'
(30) Recovery at Home - from Death's door in 4 days of natural therapies - Dr David Brownstein
(31) Nebuliser on the cheap: A USB ultrasonic mister for Essential Oils
(32) Turmeric in demand as a remedy for Coronavirus
(33) Dr Brownstein's Holistic Medicine saves Jeremiah, at home (video). Need Nebulizer, Vit A,C,D, aqueous Iodine, food-grade Hydrogen Peroxide
(34) Dr Brownstein clarifies the Nebulizer mixture
(35) No Nebulizer? Try a bowl of boiling water & a towel over your head
(36) Ways to inhale essential oils
(37) FDA permits CQ and HCQ to be used for Covid-19 (March 28) - vindicating Trump over Fauci
(38) Michigan reverses course on CQ & HCQ
(39) Ivermectin, anti-parasitic drug, kills COVID-19 in lab
(40) ICU Dr: Ventilators should be set for Oxygen Deprivation, not Respiratory Failure
(41) Another Dr. Brownstein video - Kendra's recovery
(42) Main advantage of wearing a Mask (when out) is that it stops you from touching your face
(43) COVID-19 starves your body of oxygen by binding to the heme groups in hemoglobin in your red blood cells
(44) 85 COVID Patients at Dr Brownstein's Center for Holistic Medicine: Zero Hospitalizations and No Deaths
(45) Remdesivir & Chloroquine effectively inhibit Covid-19 vitro; authors include Zhengli Shi, director of P4 lab at Wuhan Institute of Virology
(46) New drugs EIDD-1931, EIDD-2801 for Covid-19

(1) Prophylacytic Dosage of Chloroquine or Hydroxychloroquine, from the Government of India

To protect yourself, take Chloroquine or Hydroxychloroquine, and Zinc. The standard dosage to prevent Malaria: for adults, 2 x 250 mg tablets of Chloroquine Phosphate, once a week after taking food; take them on the same day each week.

The dose of Hydroxychloroquine as Prophylaxis to prevent Covid-19, from the Government of India, is:

https://www.businesstoday.in/current/economy-politics/coronavirus-outbreak-icmr-recommends-use-hydroxy-chloroquine-critical-covid-19-cases/story/399005.html

[...] For healthcare workers, a dose of 400 mg twice a day on day 1, followed by 400 mg once weekly for next 7 weeks, has been prescribed. The medicine has to be taken with meals, as per the report.

The task force has recommended a dose of 400 mg twice a day on day 1, followed by 400 mg once weekly for next 3 weeks for household contacts of laboratory confirmed cases. This has to be taken with meals.
{endquote}

https://www.expresshealthcare.in/news/advisory-on-use-of-hydroxy-chloroquine-as-prophylaxis-for-sars-cov-2-infection/417793/

Coronavirus outbreak: ICMR recommends use of hydroxy-chloroquine for critical COVID-19 cases

Hydroxy-chloroquine is recommended only for preventive treatment of healthcare workers and individuals in close contact of coronavirus patients

Chitranjan Kumar New Delhi Last Updated: March 23, 2020 | 20:40 IST

The National Taskforce for COVID-19 recommends the use of hydroxy-chloroquine for prophylaxis of SARS-CoV-2 infection for selected individuals as follows:

Eligible individuals:

o Asymptomatic healthcare workers involved in the care of suspected or confirmed cases of COVID-19

o Asymptomatic household contacts of laboratory confirmed cases

Dose:

o Asymptomatic healthcare workers involved in the care of suspected or confirmed cases of COVID-19: 400 mg twice a day on Day 1, followed by 400 mg once weekly for next 7 weeks; to be taken with meals

o Asymptomatic household contacts of laboratory confirmed cases: 400 mg twice a day on Day 1, followed by 400 mg once weekly for next 3 weeks; to be taken with meals

Exclusion/contraindications:

o The drug is not recommended for prophylaxis in children under 15 years of age.

o The drug is contraindicated in persons with known case of retinopathy, known hypersensitivity to hydroxychloroquine, 4-aminoquinoline compounds
{endquote}

The next best remedy may be Olive Leaf Extract - take one tablet per day.

Bitter Melon, a vegetable which tastes like quinine and contains closely-related compounds, would probably protect you.

Other herbal products which boost the immune system should help, e.g. Noni juice or powder. ==

Dr. Vladimir Zelenko successfully treats Hasidic Jewish patients with HCQ, no need to go to Hospital

https://forward.com/news/national/442285/coronavirus-hydroxychloroquine-trump-doctor/

video: https://www.thegatewaypundit.com/2020/03/stunning-ny-doctor-vladimir-zelenko-finds-100-success-rate-in-350-patients-using-hydroxychloroquine-with-z-paks-video/

(2) Two common drugs, Chloroquine and Kaletra, found to kill Coronavirus; but CDC & FDA bureaucrats want to delay

Chloroquine may offer a cheap cure from Coronavirus

- by Peter Myers, March 21, 2020; update March 22, 2020.

While the FDA fiddles and Rome burns, practical researchers in China, France and Australia seem to have found cures for COVID-19 that are cheap and readily available.

Thus depriving Big Pharma of windfall profits; perhaps that it why the FDA does not sound very happy.

Chinese patients in Australia informed sceptical Australian doctors about the methods found successful in China. That's what led to the current breakthrough.

Chinese medicine uses both tradition, and a "suck it and see" approach, whereas rationalist Western researchers eschew the common touch and stick to "known facts", i.e, "Science". They are forgetting that Science is primarily inductive, not deductive.

It seems incredible that CNN, and the MSM generally, would lecture Trump for announcing the Chloroquine cure, when the FDA had not certified it for this virus. Such certification would take months, during which time millions more lives would be lost, the hospital system would break down, and the economy would suffer trillions of $ damage.

Are we expected to forget that the CDC bureaucrats bungled the testing process, allowing the virus to become established in the USA?

I found a bottle of old Chloroquine tablets, left over from years ago, and took two today, as per the standard dosage to prevent Malaria. For adults, that dosage is 2 x 250 mg tablets of Chloroquine Phosphate, once a week after taking food; you take them on the same day each week.

I also found an unopened bottle of Quinoctal tablets; these were used for locations where resistance to Chloroquine had built up. But I'll take the Chloroquine for now.

It's important for me, because my blood type is A-; blood type A is the most vulnerable to Coronavirus, and most liable to have a serious case, whereas blood type O is much less likely.

My wife arrives from San Francisco in two days, and will be in isolation for 14 days. Basically, we'll be living apart for that time. I feel that the Chloroquine has given me a fighting chance of keeping the virus at bay, should she bring it. Of course, I'll be using a mask and disposable gloves when in proximity situations.

With two common and cheap drugs, Kaletra and Chloroquine, it looks as if the Olympics can go ahead.

If you do take Chloroquine, note that it lowers your blood sugar. This can be of use to diabetics. But stick to standard doses. I grow a vegetable vine called Bitter Melon, which produces fruits like a cucumber, except that they have bumpy 'warts' on the outside. You pick them young, before the seeds inside turn red. The fruits of this vine have a bitter taste like Chloroquine, and contain a closely-related chemical. They are commonly eaten in Asian cuisine, but are also medicinal, being a remedy for Diabetes. Unfortunately, my plants are not fruiting at present, because of the dry weather, but if they were I would try them as a medicine for Coronavirus.

Big Pharma tries to scare you from self-medicating with talk of side-effects that might kill you, etc. But we can look such details up on the internet, and take our own personal conditions into account. We don't need that Accountant-called-a-"Doctor" as a middleman.

One possible side-effect of CQ and HCQ is the 'loosening up' of the retina; this is of relevance for people with eye conditions. This effect is 'rare', but may be associated with long term use (5 years), body weight and poor renal functions (kidney). Yet CQ was widely and successfully used as an anti-malarial drug for decades. Any such effect would depend on dosage and duration; the dosage I took is very low; anyway, beating the virus is my #1 priority at present.

If people distrust the Medical Profession, they have only themselves to blame. To fix their reputation, they could start by admitting that vaccines are the cause of the explosion in autism. If you haven't seen Vaxxed, download it at https://ia601601.us.archive.org/8/items/Vaxxed_20170131/Vaxxed.mp4

But first, watch this Deleted Scene, which was left out of the main film. This youtube takes less than 2 minutes: https://www.youtube.com/watch?v=jb2x7tJ33ls

(3) Australian Coronavirus patients cured with Chloroquine (Malaria drug) or Kaletra (HIV drug); no unexpected side effects

https://www.news.com.au/lifestyle/health/health-problems/coronavirus-australia-queensland-researchers-find-cure-want-drug-trial/news-story/93e7656da0cff4fc4d2c5e51706accb5

Coronavirus Australia: Queensland researchers find 'cure', want drug trial Some patients who tested positive for coronavirus in Australia have already been treated with one of the drugs and "all did very, very well," researchers say.

Sarah McPhee

MARCH 17, 20206:26AM

A team of Australian researchers say they've found a cure for the novel coronavirus and hope to have patients enrolled in a nationwide trial by the end of the month.

University of Queensland Centre for Clinical Research director Professor David Paterson told news.com.au today they have seen two drugs used to treat other conditions wipe out the virus in test tubes.

He said one of the medications, given to some of the first people to test positive for COVID-19 in Australia, had already resulted in "disappearance of the virus" and complete recovery from the infection.

Prof Paterson, who is also an infectious disease physician at the Royal Brisbane and Women's Hospital, said it wasn't a stretch to label the drugs "a treatment or a cure".

"It's a potentially effective treatment," he said.

"Patients would end up with no viable coronavirus in their system at all after the end of therapy."

The drugs are both already registered and available in Australia.

"What we want to do at the moment is a large clinical trial across Australia, looking at 50 hospitals, and what we're going to compare is one drug, versus another drug, versus the combination of the two drugs," Prof Paterson said.

Given their history, researchers have a "long experience of them being very well tolerated" and there are no unexpected side effects.

"We're not on a flat foot, we can sort of move ahead very rapidly with enrolling Australians in this trial," Prof Paterson said.

"It's the question we all have ­ we know it's coming now, what is the best way to treat it?"

Prof Paterson said positive experiences in the fight against coronavirus have already been recorded overseas, citing China and Singapore. His research team are confident they can start getting the drugs to patients in a very safe way on home soil.

"We want to give Australians the absolute best treatment rather than just someone's guesses or someone's anecdotal experiences from a few people," Prof Paterson told news.com.au.

He said they hope to be enrolling patients by the end of March.

"And that way, if we can test it in this first wave of patients, we do fully expect that there are going to be ongoing infections for months and months ahead, and therefore we'll have the best possible information to treat subsequent patients," Prof Paterson said.

"That's really our aim, to get real world experience in Australia."

He said the trouble with the data coming from China was that it wasn't really gathered "in a very controlled way", given they were the epicentre of the coronavirus outbreak at the time.

"Things were just chaotic," Prof Paterson said.

"There were these emergency hospitals being built and the system really being very, very stretched."

One of the two medications is a HIV drug, which has been superseded by "newer generation" HIV drugs, and the other is an anti-malaria drug called chloroquine which is rarely used and "kept on the shelf now" due to resistance to malaria.

He said the researchers want to study them in a "very meaningful way" against the coronavirus to "try and alleviate that anxiety of Australians".

"There have already been patients treated with these in Australia and there's been successful outcomes but it hasn't been done in a controlled or a comparative way," Prof Paterson said.

The drugs would be given orally, as tablets.

Prof Paterson said patients would be asked to participate "as soon as they're admitted" to hospital with the aim of beginning treatment "very early on in their illness".

He said the research was sparked by Chinese patients, who were first given the drug in Australia, showing their doctors information on the internet about the treatment used overseas.

"Our doctors were very, very surprised that a HIV drug could actually work against the novel coronavirus and there was a bit of scepticism," he said.

"That first wave of Chinese patients we had (in Australia), they all did very, very well when they were treated with the HIV drug.

"That's reassuring ... that we're onto something really good here." ...

(4) Drug companies prepare to deliver tens of millions of Chloroquine tablets (a cheap and a safe drug); FDA hesitant

https://www.fiercepharma.com/pharma/new-commitments-mylan-and-teva-move-to-supply-tens-millions-hydroxychloroquine-tablets-to

Novartis, Mylan and Teva to supply tens of millions of chloroquine tablets to fight COVID-19

by Eric Sagonowsky | Mar 20, 2020 12:47pm

As efforts to discover new COVID-19 medicines roll on, President Donald Trump and others this week focused attention on the decades-old malaria drug chloroquine. Bayer got things rolling with an initial donation of the drug, and now Novartis, Mylan and Teva are taking steps to deliver tens of millions of tablets.

Chloroquine and hydroxychloroquine, a more tolerable formulation, are not approved to treat COVID-19. Still, U.S. authorities and others are exploring their potential following encouraging preliminary results.

In response, Novartis has pledged a global donation of up to 130 million hydroxychloroquine tablets, pending regulatory approvals for COVID-19. Mylan is ramping up production at its West Virginia Facility with enough supplies to make 50 million tablets. Teva is donating 16 million tablets to hospitals around the U.S.

At a press conference Thursday, President Trump said the U.S. is planning to make the malaria drug available by prescription "almost immediately." Because chloroquine isn't FDA-approved to treat COVID-19, the president may have been referencing off-label use.

For his part, FDA chief Stephen Hahn stressed the need to learn more about the potential treatment. It's important to get the "right drug" to the "right patient" at the "right dosage" at the "right time," the commissioner said. The wrong dose could actually hurt a patient's condition, he added.

On Friday, NIAID director Anthony Fauci said there's no meaningful evidence to date on chloroquine and COVID-19. Any evidence so far is "anecdotal," he added. ...

The pledges from Novartis, Mylan and Teva follow Bayer's Thursday donation of 3 million tablets. Together, the commitments represent nearly 200 million chloroquine and hydroxychloroquine tablets for the global COVID-19 response.

Following preliminary reports of the drug's efficacy, shares for Indian drugmakers Cadila, Torrent and Ipca each jumped, the Economic Times reports. Those companies can also produce the medicine.

While drugmakers aim to boost availability of the med, hydroxychloroquine is already in short supply, according to the American Society of Health-System Pharmacists.

RELATED: Bayer donates millions of tablets of chloroquine to help in COVID-19 fight

Early studies of the medicine in COVID-19 patients have caught the attention of healthcare experts and market watchers. In France, a professor conducted a small study of the malaria drug in 24 patients with novel coronavirus infections. Of those who received the medicine, only 25% tested positive for the virus after six days, according to en24. Meanwhile, of those who didn't receive it, 90% tested positive after that timeframe. The French government now plans to run larger studies.

In a study published last month in Nature, authors wrote that "chloroquine is a cheap and a safe drug that has been used for more than 70 years and, therefore, it is potentially clinically applicable against the 2019-nCoV."

Aside from efforts to learn more about chloroquine, drugmakers and collaborators are working on new R&D programs and looking to repurpose existing medicines.

Follow these links to read more about drug and vaccine efforts underway.

(5) CNN Fact Check says 'Chloroquine has not been approved by the FDA to treat the coronavirus'

https://edition.cnn.com/2020/03/19/politics/fact-check-chloroquine-trump-fda/index.html

Fact check: Trump wrongly claims FDA 'approved' drug chloroquine to treat the coronavirus

By Daniel Dale

Updated 0051 GMT (0851 HKT) March 20, 2020

Washington (CNN)

President Donald Trump claimed during a White House briefing on Thursday that the Food and Drug Administration had approved the "very powerful" drug chloroquine to treat coronavirus.

Chloroquine is used to treat malaria, lupus and rheumatoid arthritis. "It's shown very encouraging -- very, very encouraging early results. And we're going to be able to make that drug available almost immediately. And that's where the FDA has been so great. They -- they've gone through the approval process; it's been approved. And they did it -- they took it down from many, many months to immediate. So we're going to be able to make that drug available by prescription or states," Trump said.

He added: "Normally the FDA would take a long time to approve something like that, and it's -- it was approved very, very quickly and it's now approved, by prescription."

Facts First: Chloroquine has not been approved by the FDA to treat the coronavirus -- and nor has any other drug, the FDA made clear in a post-briefing statement that said "there are no FDA-approved therapeutics or drugs to treat, cure or prevent COVID-19." Because chloroquine has been approved for other purposes, doctors are legally allowed to prescribe it for the unapproved or "off-label" use of treating the coronavirus if they want. But its safety and effectiveness has not been proven with regard to the coronavirus. FDA Commissioner Dr. Stephen Hahn, speaking after Trump at the briefing, said that chloroquine would be tested through a "large, pragmatic clinical trial" with coronavirus patients.

The FDA said in the statement that it is working with government and academic entities that are investigating whether chloroquine can be used "to treat patients with mild-to-moderate COVID-19 to potentially reduce the duration of symptoms, as well as viral shedding, which can help prevent the spread of disease."

Studies are underway. Hahn emphasized that this study process is necessary even though the coronavirus situation is urgent.

"We also must ensure these products are effective; otherwise we risk treating patients with a product that might not work when they could have pursued other, more appropriate, treatments," Hahn said in the statement. ...

CNN's Jacqueline Howard, Michael Nedelman and Jamie Gumbrecht contributed to this story. ==

(6) Kaletra (HIV drug) and Chloroquine: Australian researchers claim two existing drugs could 'cure' COVID-19

https://www.dailymail.co.uk/news/article-8115879/COVID-19-Australian-researchers-CURE-coronavirus.html

Have they found a cure for the coronavirus? Australian researchers claim two existing drugs could 'cure' COVID-19 after patients they tested responded 'very well' to treatment Researchers believe they've found a cure for the latest strain of coronavirus The disease has killed more than 6,500 people around the world since January Queensland researcher claims HIV and anti-malaria drugs may be the cure Currently patients cannot be cured and only supported while they recover Coronavirus symptoms: what are they and should you see a doctor?

By BRITTANY CHAIN FOR DAILY MAIL AUSTRALIA And SAM BLANCHARD SENIOR HEALTH REPORTER FOR MAILONLINE

PUBLISHED: 17:12 AEDT, 16 March 2020 | UPDATED: 18:15 AEDT, 17 March 2020

Drugs used to treat HIV and malaria could be used to tackle the coronavirus, according to scientists in Australia.

A team of infectious disease experts at the University of Queensland in Brisbane say they have seen two existing medications manage to wipe out COVID-19 infections.

Chloroquine, an anti-malarial drug, and HIV-suppressing combination lopinavir/ritonavir have both reportedly shown promising results in human tests and made the virus 'disappear' in infected patients.

The drugs are being tested as researchers and doctors around the world scramble to try and find a vaccine, cure or treatment for the deadly virus.

Around 170,000 people across the globe have now been infected with the coronavirus and over 6,500 have died.

After China managed to get a handle on its sudden outbreak other countries were blindsided by huge epidemics ­ almost 25,000 people have caught it in Italy, around 14,000 in Iran, 8,000 in Spain and more than 5,000 apiece in Germany and France.

Queensland researcher, Professor David Paterson, said he hopes to enrol people in larger scale pharmaceutical trials by the end of the month.

WHAT ARE THE DRUGS THAT COULD BE USED TO STOP THE CORONAVIRUS? CHLOROQUINE

Chloroquine is a drug which was once commonly used to prevent and treat malaria.

As humans have developed an increased natural resistance to the mosquito-borne disease, the drug has been used less frequently.

Researchers now believe it may hold the key to treating COVID-19, the latest strain of coronavirus.

Common side affects include muscle problems, loss of appetite and diarrhoea.

In February 2020, Chinese medics determined the drug may be safe and effective in treating coronavirus induced pneumonia.

LOPINAVIR/RITONAVIR (KALETRA)

The combined fixed dose drug has been used in the fight against HIV and AIDS since 2006.

Some of the negative side affects to the drug include diarrhoea, vomiting, feeling tired, headaches, and muscle aches.

Chinese medical researchers suggested the drug had successfully cured coronavirus patients after the December 2019 outbreak.

Requests have been submitted in China to start a clinical trial of the drug to accurately determine its effectiveness in fighting COVID-19.

Australian authorities are also hoping to test the drug on local patients.

Professor Paterson said it wouldn't be wrong to consider the drugs a possible 'treatment or cure' for the deadly respiratory infection.

He explained that when the HIV medication lopinavir/ritonavir was given to people infected with the coronavirus in Australia it led to the 'disappearance of the virus'.

He told Australian news site news.com.au: 'It's a potentially effective treatment.

'Patients would end up with no viable coronavirus in their system at all after the end of the therapy.'

Although the treatment had been effective in a smattering of cases, there hasn't been any controlled testing like what would be needed to test a new drug, Professor Paterson said.

'That first wave of Chinese patients we had (in Australia), they all did very, very well when they were treated with the HIV drug,' Professor Paterson said.

'What we want to do at the moment is a large clinical trial across Australia, looking at 50 hospitals, and what we're going to compare is one drug, versus another drug, versus the combination of the two drugs,' Professor Paterson said.

There have been around 300 confirmed cases of the coronavirus in Australia and three people have died.

Lopinavir/ritonavir, the anti-HIV drug being tested, is most commonly sold under the name Kaletra.

It is an antiviral medication which can be taken twice a day by people infected with HIV in order to reduce levels of the virus circulating in the body.

Regular use of the medication is intended to stop HIV progressing to AIDS, which is fatal, and may also reduce the risk of people transmitting the infection to others.

It is a type of drug called a protease inhibitor, which works by stopping viruses from using an enzyme called protease, which is vital for them to be able to spread.

Without protease viruses cannot make the fully-matured clones that they need to be able to infect other healthy cells, so the infection can't spread.

This ability to stop a virus from reproducing and infecting new cells is believed to be what apparently makes Kaletra an effective coronavirus treatment.

More than 170,000 people around the world have been infected with the coronavirus, and at least 6,512 have died. [...]

(7) FDA statement: no, these drugs are not approved as treatments for COVID-19

Livescience is a "Fact Checker' type website used by Rationalists to impose their viewpoint on the rest of us - Peter M.

https://www.livescience.com/chloroquine-coronavirus-treatment.html

Could the anti-malarial drug chloroquine treat COVID-19?

By Nicoletta Lanese - Staff Writer 20 March 2020

President Trump boasted the drug's promise, but it must still be put through rigorous clinical trials.

Yesterday (March 19), President Donald Trump boasted about the "very encouraging results" of two drugs called chloroquine and hydroxychloroquine as treatments for the novel coronavirus, claiming that the medications have "gone through the approval process" and that "we're going to be able to make that drug available almost immediately."

But the U.S. Food and Drug Administration (FDA) swiftly issued a statement to clarify that, no, these drugs are not approved as treatments for COVID-19, the disease caused by the coronavirus SARS-CoV-2. Both drugs are approved to treat malaria, lupus and rheumatoid arthritis, but must still be assessed in clinical trials before being declared a safe and effective COVID-19 treatment. Doctors in the U.S. have wide latitude to prescribe drugs "off-label," meaning for conditions beyond their initial FDA approval.

"We understand and recognize the urgency with which we are all seeking prevention and treatment options for COVID-19. FDA staff are working expeditiously on that front," FDA commissioner Dr. Stephen M. Hahn said in the statement. "We also must ensure these products are effective; otherwise we risk treating patients with a product that might not work when they could have pursued other, more appropriate, treatments." [...]

The science behind chloroquine First developed in the 1940s, chloroquine earned FDA approval as a malaria treatment in 1949 and long stood as the go-to treatment for the disease, according to the DrugBank database.

A 2005 report published in the journal Virology first raised the possibility that chloroquine and its derivative hydroxychloroquine might be effective at treating COVID-19, Dr. Len Horovitz, an internist and pulmonary specialist at Lenox Hill Hospital in New York City, told Live Science. The study revealed that chloroquine could prevent the spread of the SARS-CoV virus, which caused severe acute respiratory syndrome nearly 20 years ago, in primate cells grown in culture.

Chloroquine interferes with the virus's ability to replicate in two ways. First, the drug enters compartments called endosomes within the cell membrane. Endosomes tend to be slightly acidic, but the chemical structure of the drug boosts their pH, making the compartments more basic. Many viruses, including SARS-CoV, acidify endosomes in order to breach the cell membrane, release their genetic material and begin replication; chloroquine blocks this critical step.

The drug also prevents SARS-CoV from plugging into a receptor called angiotensin-converting enzyme 2, or ACE2, on primate cells, according to the 2005 report. When the virus inserts its spike protein into the ACE2 receptor, it sets off a chemical process that alters the structure of the receptor and allows the virus to infect. An adequate dose of chloroquine appears to undermine this process, and in turn, viral replication in general, the authors noted.

"It was thought that whatever pertained to SAR-CoV-1 might apply to SARS-CoV-2," Horovitz said.

Related: 11 deadly diseases that hopped across species

Could it work? In February, a research group led by virologist Manli Wang of the Chinese Academy of Sciences put the idea to the test and found that chloroquine successfully stopped the spread of SARS-CoV-2 in cultured human cells. Preliminary reports from China, South Korea and France suggest that the treatment is at least somewhat effective in treating human patients, and some hospitals in the U.S. have begun administering the drug, according to The New York Times. In addition, the FDA is organizing a large clinical trial to formally assess the drug's effects, the Times reported.

However, due to a short supply of chloroquine in China, and the fact that an overdose can lead to acute poisoning or death in humans, Wang's team also investigated the closely related drug hydroxychloroquine. Though it shares a similar structure, hydroxychloroquine shows lower toxicity in animals than its chemical cousin and remains widely available as a treatment for lupus and rheumatoid arthritis, the authors noted.

Wang's team tested hydroxychloroquine in primate cells and found that, like chloroquine, the drug prevented SARS-CoV-2 replication, according to a report published March 18 in the journal Cell Discovery. As of Feb. 23, seven clinical trials had been registered in the Chinese Clinical Trial Registry to test the drug's effectiveness against COVID-19 infection, the authors noted.

In the U.S., the University of Minnesota is studying whether taking hydroxychloroquine can protect people living with infected COVID-19 patients from catching the virus themselves, according to the Times.

Both chloroquine and hydroxychloroquine have been in short supply since earlier this month, according to the American Society of Health-System Pharmacists. But on March 19, the pharmaceutical company Bayer donated 3 million tablets to the federal government, and Novartis, Mylan and Teva are moving to follow suit, according to FiercePharma.

Although we won't know the results of these trials for some time, the advantage of trying out chloroquine and hydroxychloroquine as COVID-19 treatments is that the drugs' safety profiles are well understood, Horovitz said. Both drugs are generally well tolerated at prescribed doses but can cause stomach pain, nausea, vomiting, headache and more rarely, itchiness, according to the Centers for Disease Control and Prevention (CDC). When taken in high doses over many years, the drugs can cause a rare eye condition known as retinopathy.

Both medications can interact with other drugs and doses should be adjusted to account for drug interactions. Those with psoriasis should not take either drug, the CDC notes. In their current form, the drugs are also not safe for those with heart arrhythmia, or those with impaired kidneys or liver, the Times reported.

Assuming the drugs are well tolerated in clinical trials and seem effective at treating COVID-19, the FDA will take measures to increase the nation's supply, according to Hahn.

"If clinical data suggests this product may be promising in treating COVID-19, we know there will be increased demand for it," Hahn said in the FDA statement. "We will take all steps to ensure chloroquine remains available for patients who take it to treat severe and life-threatening illnesses such as lupus."

(8) Is it ok to use a drug that's not yet certified? Bureaucrats Fiddle while Rome burns

https://techcrunch.com/2020/03/20/hydroxychloroquine-chloroquine-and-other-potential-covid-19-treatments-explained/

Hydroxychloroquine, chloroquine and other potential COVID-19 treatments explained

Darrell Etherington@etherington / 5:37 am AEST o March 21, 2020

During two of this week's White House briefings, President Trump referred specifically to two potential treatments that have been identified by medical researchers and clinicians, and that have undergone various degrees of investigation and testing in the ongoing fight against the global coronavirus pandemic. It's important to note upfront that regardless of what you may have heard, from Trump or any other sources, no drugs or treatments have been proven as effective for either the prevention of contracting COVID-19 or for its treatment.

That said, a number of different clinical studies are currently in progress all over the world, and in the U.S., the National Institutes of Health is looking to fill a 400-volunteer study that will provide clinical results related to use of remdesivir, an antiviral drug developed by Gilead originally as a treatment for Ebola, but it's still only in clinical trials even for treatment of that disease. This study could also add other drug candidates as additional test therapies. Meanwhile, studies in China and France have examined the effectiveness of anti-malarial drugs, including chloroquine and hydroxychloroquine - including one small-scale study that suggests the positive effects of hydroxycholoroquine in reducing both the duration and symptoms of COVID-19 in combination with an antibiotic called azithromycin.

The important thing to keep in mind when considering these or any other potential treatments for the novel coronavirus, which is still relatively young, is that a lot of what we know about them so far is effectively anecdotal, and based not on the kind of scientifically rigorous controlled clinical studies that are normally used in the years-long development and certification of drugs. Instead, treatments like remdesivir and chloroquine/hydroxychloroquine are being deployed in the field by healthcare practitioners based on their approved use in similar (but crucially not the same) situations, like the Ebola and SARS outbreaks.

Often, they're being used under what's called "compassionate" grounds in the U.S. This effectively amounts to employing a drug that's not yet certified for general use in treatment of a patient whose condition is so severe that a doctor is willing to go to desperate lengths to try to alleviate their symptoms. This has the advantage of sidestepping typical testing and approval procedures, and requiring that the results of its use are documented, which contributes to the overall body of clinical knowledge in terms of its effects and interactions with patients and with COVID-19.

It's not a clinical study, however, and that means there are still a lot of unknowns when it comes to its use that just can't be learned or asserted based on scattered, individual instances of compassionate care treatment.

"As the Commissioner of FDA and the president mentioned yesterday, we're trying to strike a balance between making something with the potential of an effect available to the American people, at the same time that we do it under the auspices of a protocol that would give us information to determine if it's truly safe and truly effective," explained National Institute of Allergy and Infectious Diseases Director Dr. Anthony Fauci during a press conference on Friday. "But the information that you're referring to specifically is anecdotal, it was not done in a controlled clinical trial. So you really can't make any definitive statement about it."

During Thursday's White House coronavirus pandemic task force briefing, Trump made false claims that chloroquine was already approved by the FDA as a treatment for COVID-19 under an emergency authorization. FDA Director Dr. Stephen Hahn clarified that this and remdesivir were being considered and studied by the FDA, as was an approach that would use plasma extracted from patients who'd recovered from COVID-19, as a potential source of antibodies for others. Still, all of these are still quite far away from clinical deployment in any generally approved way.

Meanwhile, Fauci's cautions should be taken for what they are: Warnings that are primarily meant to emphasize that the reason the FDA requires clinical studies, even for drugs already tentatively approved for use in other cases, is because it has patient health and safety in mind. While chloroquine has been used for decades to treat malaria, and chronic rheumatoid arthritis, it can have dangerous side effects, including death, if taken incorrectly. Even when taken correctly, it can cause things like stomach distress, and even permanent damage to a person's vision.

Fauci's comments Friday explain the risks of putting too much stock in any potential treatment at this stage, even if they are showing promising results among small or even medium-sized deployments.

"You've got to be careful when you say 'fairly effective,' it was never done in a clinical trial that compared it to anything," he said in answer to a reporter's question about chloroquine's efficacy in treating SARS. "It was given to individuals and felt that maybe it worked [É] Whenever you do a clinical trial, you do standard of care, versus standard of care plus the agent you're evaluating. That's the reason why we showed back in Ebola why particular interventions worked."

A summary survey of various prospective treatments and their current status was published today In Medscape, and this includes the current state of remdesivir and chloroquine investigations, as well as a number of other drugs being studied by researchers. As has been reported here and elsewhere, there are promising signs that they could prove effective in either treatment, or treatment and even preventative use (in the case of remedesivir), but these are, as Dr. Fauci puts it, only the first step that should lead to more sophisticated clinical studies, which themselves will then need competing peer studies to eventually prove out.

(9) Hydroxychloroquine (HCQ) less effective than Chloroquine (CQ) in inhibiting SARS-CoV-2; thanks to Zhengli Shi

https://www.nature.com/articles/s41421-020-0156-0

Published: 18 March 2020

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong & Manli Wang

Cell Discovery volume 6, Article number: 16 (2020) Cite this article

Dear Editor,

The outbreak of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) poses a serious threat to global public health and local economies. As of March 3, 2020, over 80,000 cases have been confirmed in China, including 2946 deaths as well as over 10,566 confirmed cases in 72 other countries. Such huge numbers of infected and dead people call for an urgent demand of effective, available, and affordable drugs to control and diminish the epidemic.

We have recently reported that two drugs, remdesivir (GS-5734) and chloroquine (CQ) phosphate, efficiently inhibited SARS-CoV-2 infection in vitro1. Remdesivir is a nucleoside analog prodrug developed by Gilead Sciences (USA). A recent case report showed that treatment with remdesivir improved the clinical condition of the first patient infected by SARS-CoV-2 in the United States2, and a phase III clinical trial of remdesivir against SARS-CoV-2 was launched in Wuhan on February 4, 2020. However, as an experimental drug, remdesivir is not expected to be largely available for treating a very large number of patients in a timely manner. Therefore, of the two potential drugs, CQ appears to be the drug of choice for large-scale use due to its availability, proven safety record, and a relatively low cost. In light of the preliminary clinical data, CQ has been added to the list of trial drugs in the Guidelines for the Diagnosis and Treatment of COVID-19 (sixth edition) published by National Health Commission of the People's Republic of China. [...]

Whether HCQ is as efficacious as CQ in treating SARS-CoV-2 infection still lacks the experimental evidence.

To this end, we evaluated the antiviral effect of HCQ against SARS-CoV-2 infection in comparison to CQ in vitro. [...] Taken together, the data suggest that the anti-SARS-CoV-2 activity of HCQ seems to be less potent compared to CQ, at least at certain MOIs. [...]

It has been reported that oral absorption of CQ and HCQ in humans is very efficient. In animals, both drugs share similar tissue distribution patterns, with high concentrations in the liver, spleen, kidney, and lung reaching levels of 200­700 times higher than those in the plasma10. It was reported that safe dosage (6­6.5 mg/kg per day) of HCQ sulfate could generate serum levels of 1.4­1.5 mM in humans11. Therefore, with a safe dosage, HCQ concentration in the above tissues is likely to be achieved to inhibit SARS-CoV-2 infection.

Clinical investigation found that high concentration of cytokines were detected in the plasma of critically ill patients infected with SARS-CoV-2, suggesting that cytokine storm was associated with disease severity12. Other than its direct antiviral activity, HCQ is a safe and successful anti-inflammatory agent that has been used extensively in autoimmune diseases and can significantly decrease the production of cytokines and, in particular, pro-inflammatory factors. Therefore, in COVID-19 patients, HCQ may also contribute to attenuating the inflammatory response. In conclusion, our results show that HCQ can efficiently inhibit SARS-CoV-2 infection in vitro. In combination with its anti-inflammatory function, we predict that the drug has a good potential to combat the disease. This possibility awaits confirmation by clinical trials. We need to point out, although HCQ is less toxic than CQ, prolonged and overdose usage can still cause poisoning. And the relatively low SI of HCQ requires careful designing and conducting of clinical trials to achieve efficient and safe control of the SARS-CoV-2 infection.

References [...]

Acknowledgements

We thank Professor Zhengli Shi and Dr. Xinglou Yang from Wuhan Institute of Virology and Professor Fei Deng from National Virus Resource Center for providing SARS-CoV-2 strain (nCoV-2019BetaCoV/Wuhan/WIV04/2019); Professor Xiulian Sun for kind help in statistical analysis; Professor Zhenhua Zheng for kindly providing the anti-LAMP1 rabbit polyclonal antibody; Prof. Zhengli Shi for kindly providing the anti-NP polyclonal antibody; Beijing Savant Biotechnology Co., ltd for kindly providing the anti-NP monoclonal antibody; Min Zhou and Xijia Liu for their assistance with this study; Jia Wu, Jun Liu, Hao Tang, and Tao Du from BSL-3 Laboratory and Dr. Ding Gao from the core faculty of Wuhan Institute of Virology for their critical support; Professor Gengfu Xiao, Professor Yanyi Wang and other colleagues of Wuhan Institute of Virology and Wuhan National Biosafety Laboratory for their excellent coordination; and Dr. Basil Arif for scientific editing of the manuscript. This work was supported in part by grants from the National Science and Technology Major Projects for "Major New Drugs Innovation and Development" (2018ZX09711003 to W.Z.), the National Natural Science Foundation of China (31621061 to Z.H.), and the Hubei Science and Technology Project (2020FCA003 to Z.H.). [...]

(10) Hospitals are not waiting for FDA bureaucrats: Chloroquine in short supply as hospitals buy in bulk

https://www.modernhealthcare.com/supply-chain/chloroquine-short-supply-hospitals-buy-bulk

March 20, 2020 05:05 PM

Chloroquine in short supply as hospitals buy in bulk

While the U.S. Food and Drug Administration is still investigating whether the inexpensive, old anti-malaria drugs can tame symptoms and limit the spread of the highly contagious virus, hospitals have responded to clinical trials in other countries that have shown promising results.

Orders of chloroquine spiked 3,000% in March, according to data from Premier, the group purchasing and consulting organization. From January 2019 through February 2020, hospitals ordered an average of 149 units a month. More than 2,300 units were ordered through March thus far.

Its variant hydroxychloroquine experienced a 260% surge in demand, Premier data show. Hospitals typically used about 8,800 units a month, jumping to 16,110 units ordered in March.

Chloroquine phosphate tables and hydroxychloroquine sulfate tablets went into shortage on March 9 and March 19, respectively, according to the American Society of Health System Pharmacists.

All major wholesale distributors put hydroxychloroquine and chloroquine on allocation this week, which limits ordering to prevent hoarding, Premier said.

"As additional reports come forth from countries suggesting treatment protocols for COVID-19, a single source of truth in the U.S. is needed to mitigate panic-buying," Premier said in the report. The Centers for Disease Control and Prevention should study the international data and make recommendations for treatment protocols domestically, Premier offered.

Chloroquine, which is also used to treat lupus and rheumatoid arthritis, isn't typically well stocked by hospitals, if at all, said Erin Fox, a drug shortage expert and senior director of drug information and support services at University of Utah Health.

"It's more of a travel medicine to be used for malaria treatment," said Fox, adding that University of Utah Health bought a small amount at the end of February to have on hand just in case when it saw some preliminary data from China. "We don't have a lot of malaria in the U.S. - probably why it was fine for just one company to supply the entire U.S."

While a single manufacturer produces chloroquine, four additional manufacturers are approved by the FDA to make it, Premier noted. There are 10 suppliers with FDA approval to produce hydroxychloroquine, but not all of them are currently manufacturing.

Some of the manufacturers of chloroquine and related products have lowered prices and donated millions of doses to the U.S. government.

Last month, the National Institutes of Health began a randomized controlled trial for the treatment of COVID-19 patients with Gilead Sciences' antiviral drug remdesivir. It is one of several drugs that are being tested for COVID-19 treatment, but quality and pricing questions remain.

"We understand and recognize the urgency with which we are all seeking prevention and treatment options for COVID-19. FDA staff are working expeditiously on that front," FDA Commissioner Dr. Stephen Hahn, said in prepared remarks. "We also must ensure these products are effective; otherwise we risk treating patients with a product that might not work when they could have pursued other, more appropriate, treatments."

The drug supply chain is already working around restricted access to pharmaceutical ingredients. The Indian government is limiting the export of 26 ingredients, some of which are used in widely used antibiotics, to protect its domestic supply amid the pandemic.

Much of the world's supply of generic drugs comes from India, which relies heavily on China for their active pharmaceutical ingredients.

(11) Military personnel given Flu vaccine were significantly more susceptible to Coronavirus

This most important result is buried amidst platitudes. I have cut away the platitudes so that you can see the important bits - Peter M.

https://christiansfortruth.com/2020-study-shows-common-flu-shots-make-people-more-susceptible-to-coronavirus-lung-infections/

2020 Study Shows Common Flu Shots Make Recipients More Susceptible To Coronavirus Lung Infections

MARCH 20, 2020

By CFT TEAM

A 2020 study conducted by the U.S. Department of Defense entitled, Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017­2018 influenza season by Greg G. Wolff, published in Vaccine, Volume 38, Issue 2, 10 January 2020, Pages 350-354, found that military personnel who had received seasonal flu shots were significantly more susceptible to coronavirus-associated respiratory infections:

Purpose

Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. Test-negative study designs are often utilized to calculate influenza vaccine effectiveness. The virus interference phenomenon goes against the basic assumption of the test-negative vaccine effectiveness study that vaccination does not change the risk of infection with other respiratory illness, thus potentially biasing vaccine effectiveness results in the positive direction. This study aimed to investigate virus interference by comparing respiratory virus status among Department of Defense personnel based on their influenza vaccination status. Furthermore, individual respiratory viruses and their association with influenza vaccination were examined.

Results

We compared vaccination status of 2880 people with non-influenza respiratory viruses to 3240 people with pan-negative results. Comparing vaccinated to non-vaccinated patients, the adjusted odds ratio for non-flu viruses was 0.97 (95% confidence interval (CI): 0.86, 1.09; p?=?0.60). Additionally, the vaccination status of 3349 cases of influenza were compared to three different control groups: all controls (N?=?6120), non-influenza positive controls (N?=?2880), and pan-negative controls (N?=?3240). The adjusted ORs for the comparisons among the three control groups did not vary much (range: 0.46­0.51).

Conclusions

Receipt of influenza vaccination was not associated with virus interference among our population. Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections. [...]

https://www.sciencedirect.com/science/article/pii/S0264410X19313647?via%3Dihub

Volume 38, Issue 2, 10 January 2020, Pages 350-354

Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017­2018 influenza season

Greg G.Wolff

https://doi.org/10.1016/j.vaccine.2019.10.005Get rights and content

Highlights o We examined virus interference in a Department of Defense dependent population.

o Vaccinated personnel did not have significant odds of respiratory illnesses.

o Vaccinated personnel were protected against influenza.

o Odds of virus interference by vaccination varied for individual respiratory viruses.

[...] 4. Discussion

[...] Additionally, the laboratory data in our study showed increased odds of coronavirus and human metapneumovirus in individuals receiving influenza vaccination. The study finding similar results to our study found no association between influenza vaccination and RSV, adenovirus, human metapneumovirus, rhinovirus or coronavirus [12]. The same study did find a significant association between parainfluenza and influenza vaccination, but the association was in opposite directions when comparing children and adults [12]. In our disease specific investigation, virus interference trends were noticed for coronavirus and human metapneumovirus [...]

(12) French Peer-Reviewed Study: Didier Raoult announces Cure for Coronavirus: HCQ + Azithromycin

French Peer-Reviewed Study: Our Treatment Cured 100% Of Coronavirus Patients

https://www.dailywire.com/news/french-peer-reviewed-study-our-treatment-cured-100-of-coronavirus-patients

By Hank Berrien

DailyWire.com

{photo} Didier Raoult, Professor at the Faculty of Medicine of Marseille, poses on November 6, 2014 in his office at the Facutly of Medicine in Marseille, southern France.Photo by Anne-Christine Poujoulat/AFP via Getty Images

On Wednesday, Gregory Rigano, an advisor to the Stanford University School of Medicine, claimed that a world-renowned French researcher had tested a promising cure for coronavirus.

He tweeted: "Full peer-reviewed study has been released by Didier Raoult MD, PhD. After 6 days 100% of patients treated with HCQ + Azithromycin were virologically cured."

UPDATE:

Full peer reviewed study has been released by Didier Raoult MD, PhD https://t.co/DzFTv13wYn.

After 6 days 100% of patients treated with HCQ + Azithromycin were virologically cured

p-value <.0001https://t.co/vttAIWbPwJ

- Gregory Rigano (@RiganoESQ) March 18, 2020

Appearing on Fox News Wednesday night, Rigano followed up by stating:

And I'm here to report that as of this morning, about 5:00 this morning, a well-controlled peer-reviewed study carried out by the most eminent infectious disease specialist in the world - Didier Raoult, MD, PhD - out of the south of France, in which he enrolled 40 patients, again, a well-controlled peer review study, that showed a 100 percent cure rate against coronavirus. The study was released this morning on my Twitter account, @Riganoesq as well as our most recent website, @covidtrial.io. The study was recently accepted to the International Journal of Antimicrobial Agents by Elsevier.

Rigano continued, "In fact to be able to cure a virus was said to be mathematically impossible, and the first company that did it was a small biotech called Pharmacet that was acquired by Gilead Sciences in a cure for hepatitis C. What we're here to announce is a second cure to a virus of all time." ...

According to covidtrial.io, here are the backgrounds for Didier Raoult and another doctor involved in the study:

Didier Raoult created the Rickettsia Unit at Aix-Marseille University. Since 2008, Dr. Raoult has served as the director of URMITE (Research Unit in Infectious and Tropical Emergent Diseases), collaborating with CNRS (National Center for the Scientific Research), IRD (Research for the Development Institute), INSERM (National Institute of Health and Medical Research) and Aix Marseille University. His laboratory employs more than 200 people, including nearly 100 active researchers who publish between 250 and 350 papers per year and have produced over 50 patents.

Dr. Chandra Duggirala has a bio that states:

He founded Novobionics, a medical device company to treat diabetes and obesity non-invasively and invented it's double sleeve technology. He lead the company through preclinical trials and several US and international patents. He is also the Principal Investigator of the Reset-Youth trial, one of the largest clinical trials for investigating the reversibility of epigenetic markers of aging. He also founded a software company at the intersection of nutritional biology and A.I.

(13) Economist endorses CQ HCQ & Kaletra cures for COVID-19, because 'Medicines designed to treat COVID-19 won't be on pharmacy shelves for months or even years'

Economist endorses CQ HCQ & Kaletra cures for COVID-19, because 'Medicines designed to treat COVID-19 won't be on pharmacy shelves for months or even years'

https://www.economist.com/briefing/2020/03/12/understanding-sars-cov-2-and-the-drugs-that-might-lessen-its-power

Coronavirus drugs: Where we are and what we know

Chloroquine and HydroxyChloroquine tablets

By AMINA KHANSTAFF WRITER

MARCH 21, 2020 11:30 AM

Medicines designed to treat COVID-19 won't be on pharmacy shelves for months or even years, but thousands of patients are in hospitals and health clinics now. So doctors are looking to drugs that are already approved for treating other diseases.

Malaria, HIV and arthritis wouldn't seem to have much in common with SARS-CoV-2, the novel coronavirus that has upended the world in just a few short months. But medicines developed for those ailments are showing some promise against the respiratory illness at the center of the pandemic.

Here's a closer look at some of the medicines being tested to see if they're effective against COVID-2.

Chloroquine

This drug has been used to treat patients with malaria for nearly a century. It is a synthetic version of quinine, a natural compound that people have been extracting from the bark of cinchona trees since the early 1600s.

Chloroquine works by essentially slowing down how efficient the virus is at entering cells, which can slow the rate of replication, said Karla Satchell, a microbiologist at Northwestern University Feinberg School of Medicine. To fight malaria, it essentially helps poison the digestive system of some blood parasites in the genus Plasmodium that are spread to humans through infected mosquitoes.

COVID-19 is caused by a coronavirus, not a parasite. Still, researchers hypothesized that Chloroquine could help patients with the new disease by slowing the virus' spread. It basically works by curtailing the virus' ability to use certain compartments in a cell (called vacuoles) to get itself inside its target. It's like having an extra bolt on your front door, but it doesn't keep the pathogen from kicking the door down. Think of it as "flattening the curve" inside the body, giving the immune system time to catch up.

About two dozen clinical trials are already underway in China to test Chloroquine's efficacy against the novel coronavirus. Early results show that it seemed to cut down the virus' rate of replication. Some researchers have suggested that its ability to modulate the immune system's behavior may allow it to mitigate so-called cytokine storms, a potentially deadly overreaction to the disease that can result in organ failure.

Chloroquine has several built-in advantages. It's already known to be safe in humans (though it can result in poisoning at overdose levels). It's cheap. It has a backer in President Trump, who on Thursday asked the Food and Drug Administration to examine its feasibility as a COVID-19 treatment. And in preclinical research, it's been shown to be effective against viral infections such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and HIV.

HydroxyChloroquine

As you may guess, this drug is closely related to Chloroquine. It's a potentially less toxic metabolite of the malaria drug that's used to treat certain autoimmune diseases like lupus and rheumatoid arthritis. Scientists think it works by disrupting communications between cells in the immune system. Like Chloroquine, scientists suspect it might help to mitigate cytokine storms.

Doctors are testing it in COVID-19 patients on the theory that if Chloroquine is helpful, HydroxyChloroquine might be too, and recent lab results seem to back that up. At least seven clinical trials have begun in China to test HydroxyChloroquine in patients with COVID-19, and the University of Minnesota also launched one of its own this week.

"After 90 days we will have some indication of whether this is effective or not," and how effective it could be, said Dr. Jakub Tolar, dean of the University of Minnesota Medical School.

Early results in China are promising, showing that it inhibited SARS-COV-2 infections in the lab.

Like Chloroquine, HydroxyChloroquine has already been established as safe for use in humans - it's been on the market since the 1950s. Trump's request that the FDA investigate Chloroquine included HydroxyChloroquine as well. On Saturday, he tweeted out an endorsement of a preliminary report from France in which six patients received HydroxyChloroquine along with the antibiotic azithromycin.

Kaletra

This combination of two antiviral drugs, lopinavir and ritonavir, is used to combat HIV. It's widely available, and several clinical trials around the world are underway.

The two drugs, both protease inhibitors, have different but complementary roles when used in combination. Lopinavir prevents viral enzymes from cutting up important proteins that are key to HIV's reproduction. Ritonavir helps boost lopinavir's concentrations in cells.

Scientists wondered whether the pair might be able to disrupt SARS-COV-2's life cycle in similar ways.

But a study published this week in the New England Journal of Medicine reported no benefit for patients with severe COVID-19. While that's not great news for the drug's prospects, an editorial accompanying the paper called the work a "heroic effort." And, to be clear, it was just one study; other trials could eventually provide further insight.

Remdesivir

This drug was developed by Gilead Sciences to fight Ebola but failed to prove effective. Still, remdesivir has since been shown to have some effect against both MERS and SARS in cell lines and limited animal testing, and since those diseases are caused by coronaviruses, it may have some effect against the one that causes COVID-19.

Exactly how remdesivir works has been unclear, though a new study shows that it appears to block RNA replication during the reproductive cycle of a coronavirus.

It was given to the first COVID-19 patient in the United States for compassionate use after his condition took a turn for the worse, and he began to recover the next day, according to a case study published in the New England Journal of Medicine. Whether the drug was actually responsible for any of that improvement is unknown.

Several clinical trials in the works should provide some answers. A clinical trial sponsored by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has already launched at several locations in the U.S., including the University of Nebraska, the University of Minnesota and UC Irvine.

"Although remdesivir has been administered to some patients with COVID-19, we do not have solid data to indicate it can improve clinical outcomes," Dr. Anthony S. Fauci, director of the NIAID, said in a statement.

These clinical trials would offer some solid data as to whether it really works.

Losartan

This hypertension drug reduces blood pressure by preventing a hormone called angiotensin from binding to receptors on blood vessels, allowing them to stay relaxed.

Scientists hypothesized that losartan might help patients with COVID-19 because, as an angiotensin receptor blocker, it obstructs the site through which the virus gets into the cells, Tolar said.

This drug rounds out the trifecta of treatments that University of Minnesota researchers are putting through clinical trials; they have not yet started recruiting subjects, according to the NIH.

Other approaches

Repurposing drugs that are already on the market (or at least, proven safe) makes for a good first step in fighting a novel virus, but it's something of a blunt instrument, scientists pointed out.

That's why researchers are also studying the virus in depth to try to develop more tailored treatments from the bottom up - or at least, from a little closer to ground level.

Satchell's center is taking this route, studying the virus' proteins and other structures in depth and designing drugs to combat it. Currently, they're targeting the molecular factories that viruses set up to manufacture more copies of themselves.

"If you just walked up to a machine and stuck a screwdriver in it somewhere, it would stop working," she said. The trick is to figure out where to stick the screwdriver, and what it should look like. "And that's what we're trying to find."

The advantage here is that you get a drug that does essentially exactly what you want it to do. The drawback is that scientists have to start from the ground up, so getting a drug to the public may take a little longer - perhaps two years, Satchell estimated.

Luckily, scientists can also draw on research into other coronaviruses, such as those that caused the SARS outbreak in 2003 and the MERS outbreak in 2012. Those events came and went so quickly that promising research was largely dropped before drugs could be developed and made available.

Since all three coronaviruses are genetically very similar, that preliminary work could give scientists a leg up in developing weapons against COVID-19 and shorten the process to around 12 to 18 months, Satchell said.

Continuing this research even after the current pandemic ends will be key to help prevent future outbreaks, she said.

After all, consider the discontinued research into SARS and MERS. If that work had resulted in effective drugs, we might have a treatment for COVID-19 today, she pointed out. Similarly, the work being done on SARS-CoV-2 could prove useful when future outbreaks hit, even if the pathogens causing them are slightly different.

"I hope one of the lessons that we have from this is that research should keep going even if the crisis goes away," she said.

(14) NYT dismisses chloroquine cure for COVID-19

https://www.nytimes.com/2020/03/19/health/coronavirus-drugs-chloroquine.html

With Minimal Evidence, Trump Asks F.D.A. to Study Malaria Drugs for Coronavirus

The use of the existing drugs against the new virus is unproven, and some shortages have already been reported.

By Denise Grady and Katie Thomas

Published March 19, 2020 Updated March 20, 2020

President Trump on Thursday exaggerated the potential of drugs available to treat the new coronavirus, including an experimental antiviral treatment and decades-old malaria remedies that hint of promise but so far show limited evidence of healing the sick.

No drug has been approved to treat the new coronavirus, and doctors around the world have been desperately administering an array of medicines in search of something to help patients, especially those who are severely ill.

The malaria drugs, chloroquine and hydroxychloroquine, are among the remedies that have been tried in several countries as the virus has spread around the world, killing at least 9,800.

Both drugs have gone into short supply in the United States this month, as word has spread of their potential benefit to coronavirus patients. Manufacturers of the generic products have said they are ramping up production. One company, Teva, said it would donate millions of pills of hydroxychloroquine to hospitals, and another company, Mylan, said it would restart production of the drug. Doctors in China, South Korea and France have reported that the treatments seem to help. But those efforts have not involved the kind of large, carefully controlled studies that would provide the global medical community the proof that these drugs work on a significant scale.

In a White House briefing Thursday, Mr. Trump said the anti-malaria drugs had shown "tremendous promise."

"I think it's going to be very exciting," he said. "I think it could be a game changer, and maybe not."

The drugs' potential has been highlighted during broadcasts on one of Mr. Trump's favorite news channels, Fox News, where hosts like Laura Ingraham, Tucker Carlson and Jeanine Pirro have trumpeted the possibility of a real treatment.

"They've gone through the approval process," Mr. Trump said of the drugs. "It's been approved, and they did." But the F.D.A. has not approved any drugs for use in the treatment of coronavirus, and the drugs were already available, to treat malaria as well as rheumatoid arthritis and lupus. To date, the F.D.A. has not added the coronavirus to the list of illnesses for which the drugs are specifically approved. Then again, doctors have been free to use both old malaria drugs for any purpose deemed appropriate.

At the briefing on Thursday, Dr. Stephen M. Hahn, who has been the commissioner of the Food and Drug Administration for only three months, tended to walk back some of the president's more inflated predictions that these drugs might vanquish the virus altogether.

He said Mr. Trump had asked the agency to look into chloroquine to fight the coronavirus, and that it was setting up a large clinical trial to evaluate the drug.

Some hospitals in the United States have already begun using the drugs for coronavirus patients, apparently reasoning that they may help and are unlikely to do harm. They are cheap and relatively safe. Laboratory studies have found that they prevent the coronavirus from invading cells, suggesting that the drugs could help prevent or limit the infection.

Not everyone can take the drugs: They are not safe for people who suffer from heart arrhythmia, or those with impaired kidneys or liver.

The University of Minnesota is conducting a study in which people who live with a coronavirus patient are being given hydroxychloroquine to find out if it can prevent the infection.

Dr. Hahn also said that the agency was allowing sick patients to use remdesivir, the not-yet-approved antiviral drug made by Gilead. Such so-called "compassionate use" programs allow patients to take unapproved, experimental drugs if they have no other options. Remdesivir has already been given to patients on a compassionate-use basis, including the first coronavirus patient in the United States, who was treated in Washington State in late January.

Remdesivir is being studied in clinical trials, but the results are not available yet. It was studied to treat Ebola, but did not work well enough to be useful for that disease.

Dr. Hahn noted that the agency's job was to prove that drugs were safe and effective. "What's also important is not to provide false hope, but to provide hope," he said.

As word has spread about chloroquine's potential, demand in the United States has overwhelmed the country's only supplier of the drug, the New Jersey generic manufacturer Rising Pharmaceuticals.

Chloroquine has been in short supply since March 9, according to the American Society of Health-System Pharmacists, which tracks drug shortages. Hydroxychloroquine, which is made by more companies, has been in shortage since Thursday.

Ira Baeringer, chief operating officer of Rising Pharmaceuticals, said his company had been tracking the use of the drug in China and elsewhere. They increased production about three weeks ago, he said, and are meeting all of their orders. But he acknowledged that pharmacies may currently have low stocks.

(15) Olive Leaf ingredient oleuropein acts as an antiviral agent

https://www.dynamicchiropractic.com/mpacms/dc/article.php?id=38381

Dynamic Chiropractic ­ July 14, 1997, Vol. 15, Issue 15

Herbal Health Report: Olive Leaf Extract Regains Interest as a Superb Anti-microbial Agent

BY PAUL S. NASH, DC, CCN, LIC. ACU.

Headlines warning of antibiotic resistant bacteria, rare strains of flesh eating strep, rising HIV rates, and deadly outbreaks of viruses such as Ebola and Hanta are on the rise, prompting growing concerns amid the medical community and the population at large. Endeavors to slow the tide of increasingly virulent microorganisms has researchers clambering for new and more potent drugs. But while we may be winning some battles, the odds favor our much smaller opponents, which use shear numbers and genetic variance to outwit our efforts, and which may ultimately be winning the war.

Interestingly, we are finding powerful allies in the plant world. From an evolutionary perspective, our bodies have relied on plants for maintenance and repair. Botanicals, which are the foundation of many pharmaceuticals, are now gaining new respect among researchers and practitioners of traditional medicine. Modern botanicals are produced by advanced extraction processes; they are highly concentrated substances yielding powerful weapons in the battle against disease, while promoting dynamic balance in the organism as a whole. Many herbal products possess a high degree of safety and efficacy without the toxic side effects seen in most pharmaceuticals.

The Mediterranean olive or olea europa has recently rekindled the interest of scientists and clinicians alike because of its potent medicinal value. The olive is a hardy tree that manufactures its own potent antibiotic substances to fend off disease causing bacteria, fungi, parasites and insects. In 1908, Bourquelot and Vintilesco isolated a bitter glucoside (structurally classified as an iridoid) from olive leaves and named it oleuropein. In 1960, scientists from Holland further isolated elenolic acid (a monoterpene), which was eventually determined to be the chemical constituent with the greatest activity against infectious microbes. Later in that same decade, viral researchers at a U.S. pharmaceutical company (Upjohn Co., Kalamazoo, MI) demonstrated that elenolic acid evidenced remarkable inhibition of viruses and bacteria without damaging the host cells in vitro.

Although it is not known exactly how oleuropein acts as an antiviral agent, there are several proposed mechanisms:

interference with specific amino acid production processes vital to the life cycle of the virus;

interference with viral infection and/or spread by inactivating the virus or by prohibiting shedding, budding or assembly at the cell membrane;

immune activation of host defense through direct stimulation of phagocytosis;

neutralization of the production of reverse transcriptase and protease (relates to retroviral ability to alter the host cell RNA);

penetration of infected host cells while achieving an irreversible inhibition of viral replication.

The antiviral activity of elenolic acid was shown to be greatest in an alkaline environment (pH 7.5), which is very close to the normal human pH range of 7.35-7.45. Virucidal activity was diminished by incubation with amino acids lysine, glycine, cysteine and histidine, and to a lesser extent with phenylalanine, tryptophan, serine and threonine. Because the elenolic acid could be inactivated by free amino acids circulating in the bloodstream, research was apparently discontinued. Then in 1994, an independent research team achieved a breakthrough that apparently overcame this hurdle, allowing sufficient levels of elenolic acid to be delivered to the body. Today, preparations of olive leaf extract are standardized to contain approximately 5% elenolic acid content, and researchers are presently working to increase that percentage to 15%.

Viruses that have shown susceptibility to elenolic acid in vitro include:

herpes (MRS); vaccinia; pseudorabies; influenza A & B; Newcastle disease; parainfluenza 1, 2, & 3; coxsackie A21; encephlomyocarditis; polio 1, 2, & 3; vesicular stomatitis; sindbis; reovirus; Moloney murine leukemia; Rauscher murine leukemia; Moloney sarcoma. In vivo activity has been demonstrated in hamsters with reduced viral yields from animals infected with parainfluenza 3 virus.

Reportedly, some clinicians have been testing oleuropein with HIV patients. Interestingly, protease inhibitors have gained a great deal of press for their potential in the fight against AIDs. These are believed to actively block the site of HIV protease. When combined with other classes of drugs researchers have reported remission in infected patients. We anxiously await their reports on effectiveness.

Oleuropein has also been shown effective against many bacteria. The proposed mechanisms of antibacterial activity are as follows:

slows the growth rate and inhibits a number of enzymes;

induces damage to the cell membrane thus affecting its permeability and resulting in a leakage of cytoplasmic constituents;

inhibition of micrococcal nuclease and lysozyme;

inhibits enzymes by reacting with the e-amino group of exposed lysine residues and the exposed n-terminal amino group of polypeptide chains;

irreversible inhibition of DNA polymerase II and inhibition of DNA polymerase III holoenzymes;

immune activation of host defense through direct stimulation of phagocytic activity.

Bacteria that have shown susceptibility include: lactobacillus plantarum; l. brevis; pediococcus cerevisiae; leuconostoc mesenteroides; bacillus cereus; staphylococcus aureus; bacillus subtilis; enterobacter aerogenes; e. cloacae; escherichia coli; salmonella typhinurium; pseudomonas fluorescens; p. solanacearum; p. lachrymans; erwinia carotovora; e. tracheiphila; xanthomonas vesicatoria; and corynebacterium michiganese.

Oleuropein has also been found effective against strains of malaria, including plasmodium falciparum, plasmodium vivax, plasmodium ovale and plasmodium malariae. Malaria is a protozoan infection characterized by fever, chills and profuse sweating, and occurs primarily in tropical regions. Malarial infection can occur by transmission of the protozoa parasite following the bite of an infected Anopheles mosquito. First the sporozoites multiply in cells of the liver, then after a period usually lasting 2-4 weeks, the parasite may invade the red blood cells. Next, the merozoites may multiply before being released into the bloodstream. Antimalarial activity was reported by clinicians in the 1850s who administered decoctions of olive leaf to infected patients. In 1906, scientists claimed that olive leaf extracts were superior to quinine, the primary treatment of malaria at the time. Since malaria has developed resistance to many of our present day drugs, clinicians may want to consider olive leaf extract as an addition to the treatment of malaria once again.

Fungal and yeast infections have been the focus of a great deal of attention from many health care providers. A major contributing factor to this increase is theorized to result from the overuse and overprescription of bacterial antibiotics. These substances, once believed to be a panacea or cure-all, are now realized to have resulted in superstrains of antibiotic resistant bacteria that are increasingly more difficult to treat.

Furthermore, the natural bacteria living on our skin and mucous membranes (such as the lungs and intestinal tract) provide a blanket of protection from other harmful organisms. These microbes secrete substances that may be toxic to other invading organisms and either benefit or have a neutral effect on our bodies and cells.

Because antibiotics kill both the friendly and unfriendly organisms, they can upset the delicate balance of our body's natural defenses. The result has been a paradise for yeast and fungi not harmed by the antibiotics, which may flourish without competition from our natural bacterial allies. Since yeast prefer a diet high in sugars, our overindulgence in sweets has further benefited yeast populations and contributed to illness and disease. Fungi and yeast species that have shown sensitivity to oleuropein include geotrichum candidum, rhizopus sp. and rhizoctonia solani.

Oleuropein and other structurally related iridoids have also demonstrated anti-inflammatory properties when administered either orally or topically. Although oleuropein's activity as an anti-inflammatory may be moderate in comparison to other naturally occurring iridoids, it could still be considered noteworthy. And since virtually all disease results in an inflammatory response, oleuropein might offer some benefits in any health condition.

In the United States, as in most Western countries, atherosclerotic heart disease and stroke remain the number one killer despite all the advancements in medicine. A major risk factor for atherosclerosis is the elevation of serum lipids (specifically low density lipoproteins or LDLs). Oxidized low density lipoproteins can be taken up by endothelial cells and monocytes by way of their scavenger receptor. This can lead to the formation of cholesterol ester-loaded foam cells and atherosclerotic plaques. In the advanced stages, this can lead to the death of the endothelial cell (which is the cell at the innermost layer of the blood vessel). Oleuropein is a polyphenolic compound; these naturally-occurring phytochemicals are considered to be very potent antioxidants. Oleuropein has been shown to inhibit the oxidation of LDLs.

This may be the reason oleuropein has shown antiatherogenic activity. Oleuropein content in the diet of the Mediterranean population has been proposed among other postulates for the decreased incidence of coronary heart disease when compared to its Western counterpart.

Hypertension is a common disorder encountered and diagnosed by many physicians. Because there is usually no pain associated with its occurrence, many patients are unaware of problems until they visit their doctors or until it is too late, as in the case of a stroke. An important component of olive leaf extract is oleuropeside. This compound has been shown to act as a hypotensive by activating the vasodilation of blood vessels. Decreased arterial blood pressure, decreased atrial rate, decreased cardiac contractility and anti-arrhythmic effects have all been attributed to oleuropeside. It appears that other olive leaf ingredients act synergistically to potentiate the relaxant effect of oleuropeside; thus, the whole is greater than the individual parts.

Diabetes mellitus is a syndrome characterized by increased blood sugar resulting from impaired insulin secretion and/or effectiveness. Numerous complications include retinopathy, atherosclerotic disease, nephropathy and neuropathies. Olive leaves have long been touted as an antidiabetic agent in herbal folklore. Scientists have demonstrated that the oleuropeside content of the plant is responsible for its hypoglycemic activity. The potentiation of glucose-induced release of insulin and an increased peripheral uptake of glucose are two proposed methods of antihyperglycemic activity.

The oleuropeside content is highest in the winter months and samples collected in these months evidenced the greatest hypoglycemic and antihyperglycemic activity. Olive leaves collected in the summer months may contain little or no oleuropeside. Individuals with insulin dependent diabetes should be cautioned against using oleuropein or other plant extracts to control diabetes as this could be extremely dangerous. However, individuals with non-insulin dependent and insulin dependent diabetics may want to closely monitor their glucose levels when taking oleuropeside rich oleuropein.

Hyperuricemia is a finding that is commonly associated with gout. Because of the high uric acid content in the bloodstream, crystals may deposit in the joints. Swelling, warmth, redness and exquisite tenderness most often affects the metatarsophalangeal joint of the great toe, but the instep, ankle, knee, wrist and elbow are also common sites. Uric acid may also precipitate in organs, such as the kidney, where aggregates of gravel or stones may lead to obstructive uropathy. A report in the Belgian Pharmacology Journal (March-April 1994) recorded hypouricemic activity in aqueous olive leaf extracts. This may lead to a promising method of managing hyperuricemia and its complications.

Although the following accounts are anecdotal, I have seen numerous benefits in practice using oleuropein. Perhaps the most common is patients reporting tremendous increases in energy, even patients with chronic fatigue. Patients have also reported toenail fungus that disappeared in cases that had been unresponsive to medical care, decreased severity and length of herpes outbreaks, and hasty recovery from colds and flus.

Oleuropein is best taken with water, one hour or more away from food, as the activity of elenolic acid in the oleuropein may be decreased by certain amino acids found in protein- containing foods and supplements. Therefore, if one wishes to take amino acids such as lysine they may wish to take the oleuropein at a different time of the day. Some individuals may experience symptoms of detoxification resulting from toxins released into the bloodstream following the death of a virus, bacteria, fungus or parasite. Symptoms of detoxification are natural and may include headaches, muscle and joint aches, skin rash or sensitivity, irritability, nervousness, fatigue and mental dullness. Individuals with hypoglycemic tendencies may likewise experience similar symptoms. In either case, proceed slowly by taking only one or two pills and gradually increase the dosage when symptoms subside. A reasonable therapeutic dose would be 6-9 pills in divided doses per day (some practitioners have reportedly used doses double this amount).

The olive has long been a symbol of hope, victory and friendship since biblical days. Perhaps the time has come for us to reconsider the powerful role this tree can play in contemporary health care.

References: [...]

(16) Ole and HT may be useful against other viruses ... including severe acute respiratory syndrome associated coronavirus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790717/

Journal ListHHS Author ManuscriptsPMC2790717

Biochem Biophys Res Commun. 2007 Mar 23; 354(4): 872­878.

Published online 2007 Jan 24. doi: 10.1016/j.bbrc.2007.01.071

PMCID: PMC2790717

NIHMSID: NIHMS18537

PMID: 17275783

Discovery of Small-Molecule HIV-1 Fusion and Integrase Inhibitors

Oleuropein and Hydroxytyrosol: I. Fusion Inhibition

Sylvia Lee-Huang,1,Ý* Philip Lin Huang,2,§* Dawei Zhang,1,§ Jae Wook Lee,3 Ju Bao,3 Yongtao Sun,1 Young-Tae Chang,3 John Zhang,3 and Paul Lee Huang4,*

Abstract

We have identified oleuropein (Ole) and hydroxytyrosol (HT) as a unique class of HIV-1 inhibitors from olive leaf extracts effective against viral fusion and integration. We used molecular docking simulation to study the interactions of Ole and HT with viral targets. [...]

We previously reported that olive leaf extract is potent against HIV-1 [3]. We investigated its anti-HIV properties and discovered that oleuropein (Ole) and its main metabolite, hydroxytyrosol (HT) are the key anti-HIV components. They are active against multiple stages of the HIV-1 life cycle, inhibiting cell-to-cell HIV-1 transmission and viral core antigen p24 production. [...]

DISCUSSION

Ole and HT are small molecules with molecular weights of 539 and 153 respectively. Their inhibition of the fusion-promoting refolding of gp41 is an excellent example of how small molecules can block formation of protein­protein complexes. We narrowed down the target of binding to a hydrophobic pocket on the gp41 inner core. This pocket is highly conserved among the different HIV clades. Consistent with this, we found that Ole and HT are active against a panel of HIV-1 primary isolates that includes both M and T tropic strains from different clades. Our results suggest that Ole and HT may be useful against other viruses with type I transmembrane envelope glycoprotein, including severe acute respiratory syndrome associated coronavirus [23, 27], respiratory syncytial virus, Ebola virus [28], measles virus [29], and avian flu [30, 31]. [...]

References: [...]

(17) Urology site endorses natural treatment: How Viruses Work and How to Prevent and Eliminate Them

https://www.urologyofva.net/articles/category/healthy-living/4126629/how-viruses-work-and-how-to-prevent-and-eliminate-them-naturally

How Viruses Work and How to Prevent and Eliminate Them Naturally

Urology of Virginia

Last updated: 03-13-2020

Read original article here

How Viruses Work and How to Prevent and Eliminate Them Naturally ...

https://www.organiclifestylemagazine.com/how-viruses-work-and-how-to-prevent-and-eliminate-them-naturally

How Viruses Work and How to Prevent and Eliminate Them Naturally

October 27, 2014

by Michael Edwards

Last updated on: March 10, 2020

Nature's Zombies

We have identified more than 2,000 viruses, though only 10% infect humans. Scientists used to think human viruses do not affect animals and animal viruses do not affect humans, but we now know that viruses not only jump species, sometimes they combine to create new strains. New strains can present a clear threat to human survival.

In 1918 the Spanish flu pandemic was a global killer. Estimates of the dead range from 20-100 million, up to 5% of the population­all within one year. Unlike previous flu pandemics and epidemics, this flu strain killed healthy adults, whereas most flu strains targeted children, the elderly, and the infirmed. More people died in this one-year pandemic than the four years of the bubonic plague.

We often hear that many dangerous strains of influenza begin in China. This belief is based on the dense population of humans living in close proximity to high populations of animals. Many dangerous viral strains have been found to originate in China jumping from birds or pigs to the human population. Birds alone have been found to carry as many as 15 viral strains.

Contents

A virus is a pathogenic, parasitic organism that isn't classified as being alive, since a cell is an essential to our definition of life. A virus has no cell membrane, no metabolism, no respiration and cannot replicate outside of a living cell. A virus is a creepy half-live, single strand or double strand of DNA or RNA or both, looking for a cell to invade. Once inside, it reprograms the cell with its DNA or RNA and multiplies on mass, bursting through the cell with a thousand or more new virus strands seeking new cells to invade. RNA viruses mutate more easily than DNA viruses. (SARS, bird flu, West Nile virus, swine flu, hepatitis, measles, polio, yellow fever, and Ebola are among the many RNA viruses).

If two viruses invade the same cell (a bird virus and a human virus, for instance) their DNA can combine to form a new virus, a potentially virulent one. The same is true if two animal viruses combine and jump species to humans.

Viruses have two life cycles: the lytic cycle and the lysogenic cycle.

Lytic Cycle

In the lytic cycle, the virus focuses on reproduction. It invades a cell, inserts its DNA and creates thousands of copies of itself, bursts through the cell membrane, killing the cell, and each new viral strand invades new cells replicating the process.

Lysogenic Cycle In the lysogenic cycle, viruses remain dormant within its host cells. The virus may remain dormant for years. Herpes and chickenpox are good examples. (Chicken pox can cause shingles in later life when the dormant virus reactivates.)

How Does the Body Fight a Virus?

Our bodies fight off invading organisms, including viruses, all the time. Our first line of defense is the skin, mucous, and stomach acid. If we inhale a virus, mucous traps it and tries to expel it. If it is swallowed, stomach acid may kill it. If the virus gets past the first line of defense, the innate immune system comes into play. The phagocytes wage war and release interferon to protect surrounding cells. If they cannot destroy the invading force, the phagocytes call the lymphocytes into play.

Our lymphocytes, T cells and B cells, retain a memory of any previous infection that was serious enough to bring them into the battle. Antibodies were formed and the body knows how to fight any infection it recognizes. (This is how vaccinations work. The body has fought a similar infection). But viruses can mutate, sometimes so much that they body cannot recognize them as a similar infection they fought in the past. They can also be so fast acting, they can kill before the lymphocytes are brought into play.

How Does Conventional Medicine Treat a Virus?

Antiviral medications do not directly kill the virus; they trap it within the cell, keeping it from reproducing. The only catch is that the anti-viral has to be taken with 48 hours of symptom onset or it doesn't work.

Antibiotics don't kill viruses. They kill bacteria, not viruses. And they kill good bacteria that we need to keep our gut in balance. Taking antibiotics when you have a viral infection can cause an immediate overgrowth of Candida, giving the immune system an additional system-wide infection to deal with when it needs all of its resources to fight a viral infection. ...

Echinacea

Echinacea not only supports the immune system, it also has been proven to reduce the severity and duration of viral infections. ...

Elderberry

A double-blind trail showed elderberry extract's ability to reduce symptoms of influenza and speed recovery. It also showed elderberry's ability to enhance immune response with higher levels of antibodies in the blood. It is believed to inhibit a virus's ability to penetrate healthy cells and protect cells with powerful antioxidant S. Elderberry has also been shown to inhibit replication in four strains of herpes viruses and reduce infectivity of HIV strains.

Green Tea

The flavonoids in green tea are believed to fight viral infections by preventing the virus from entering host cells and by inhibiting replication.

Olive Leaf Extract

Though double-blind clinical trials are needed, olive leaf extract has been shown to inhibit replication of viruses. In one study, 115 of 119 patients had a full and rapid recovery from respiratory tract infections while 120 of 172 had a full and rapid recovery from viral skin infections such as herpes. ...

(18) CQ and HCQ are zinc ionophores, i.e., carriers of zinc ions into the lung cell's interior; Quercetin dies the same, and it can be purchased over-the-counter

From: John Powell <jjjohnpowelll@gmail.com>

My understanding is that Chloroquine and Hydroxychloroquine are nothing more than zinc ionophores, i.e., carriers of zinc ions into the lung cell's interior.

The medical reading I've been doing tells me that it is the zinc which does the clearance/termination of the corona virus. The clearance/termination of the virus is not done by the Chloroquine or the Hydroxychloroquine. They merely transport the zinc ions into the cell.

There are other zinc ionophores which do the same, the most potent of which is a naturally-occurring substance call Quercetin, and it can be purchased over-the-counter. I buy it from an online company called Bulk Supplements (<https://bitli.pro/IPVm_3638b00a> bulksupplements.com), and I've been consuming it along with a zinc supplement, for approximately twenty-five years.

Note (Peter M.): take a Zinc supplement too.

(19) Dr. Vladimir Zelenko successfully treats Hasidic Jewish patients with HCQ, no need to go to Hospital

https://forward.com/news/national/442285/coronavirus-hydroxychloroquine-trump-doctor/

March 24, 2020

This doctor was already treating patients with Trump's 'gift from God' drug - before FDA approval

Ari Feldman

March 24, 2020

On Tuesday morning, the controversial and experimental coronavirus treatment program being run by a Hasidic doctor who claimed he had kept more than 500 symptomatic patients out of the hospital was shut down. By afternoon, after intervention from the White House, it was up and running again.

The doctor, Vladimir Zelenko, has been in isolation because he is immunocompromised. But he is directing perhaps the world's most extensive, unsanctioned medical experiment related to coronavirus - the use of the anti-malaria drug hydroxychloroquine to treat Covid-19, a something President Donald Trump has been touting for days as a "game changer" in the fight against the virus.

The experiment is controversial: Trump's top medical adviser, Dr. Anthony Fauci, has cautioned against use of the drug to treat the virus, calling evidence of its effectiveness "anecdotal." On Monday evening, New York banned off-label use of the drug, which is also used to treat lupus and rheumatoid arthritis, outside state-approved clinical trials.

But on Tuesday afternoon Vice President Mike Pence announced on Fox News that the Food and Drug Administration was approving off-label use of the drug "right now."

"Doctors can now prescribe chloroquine for that off-label purpose of dealing with the symptoms of coronavirus," Pence said.

Zelenko, 46, a Russian immigrant who became Hasidic as a young adult. and runs a medical practice in Orange County, N.Y., has been doing that for more than a week. His self-reported success - no deaths among any of his clients, who are almost all Hasidic Jews - has given him an audience on Fox News and across conservative news sites, as supporters of the president look to bolster Trump's attempts to curtail coronavirus - and the economic repercussions - as soon as possible.

Though he has been operating in uncharted medical territory, backed up by only a small number of studies, Zelenko has attracted interest from other doctors looking for ways to stem the growing wave of Covid-19 hospitalizations.

"I'm not claiming any miracle cures," Zelenko said in a telephone interview Tuesday morning. "I'm creative, and I think out of the box. We have an unprecedented health crisis - it requires unique thinking."

Zelenko has been urging people in the ultra-Orthodox world to stay calm, even as he has sounded the alarm about potentially high rates of infection in Hasidic villages and neighborhoods. In a video message shared on WhatsApp, he said that the majority of people infected with the virus will require no treatment.

"You gotta relax," he said, speaking from the driver's seat of his car. "There is no room for young people to get nervous or cause hysteria, you will all be fine."

Zelenko has been directing his medical staff from quarantine in his home in Englewood, N.J., because he had his right lung removed last year during treatment for lung cancer. He said he is taking a low dose of hydroxychloroquine himself, prophylactically.

Zelenko said that he has been using a cocktail of drugs on his patients:

hydroxychloroquine, in combination with azithromycin - an antibiotic to treat secondary infections - and zinc sulfate, which studies have suggested slows down virus replication in the body. He said he had been administering the cocktail to patients with shortness of breath of any age, and those over 60 years old or who are immunocompromised and exhibiting milder symptoms. He said he is not treating asymptomatic people under 60 who are healthy or low risk.

He acknowledged that his regimen was new and untested, and that it was too soon to assess its long-term effectiveness. But he said he thinks the rewards of implementing his treatment method are much greater than the risks of waiting to verify its efficacy, and he insisted that he is seeing only positive results from using hydroxychloroquine, in combination with two other drugs, on an outpatient basis for patients at higher risk of dying from the virus.

His patients in Kiryas Joel are facing a potentially high rate of infection, due to their density and to the village's slowness to shut down all of its institutions in the wake of government-ordered school closures and restrictions on social gatherings. Their spiritual leader, Rabbi Aharon Teitelbaum, has been diagnosed with the virus.

Zelenko declined to say whether he was treating Teitelbaum with the regimen, but said that he could confirm that there was a "high" number of infections among the religious and spiritual leadership of the town.

Zelenko said that about 350 of the roughly 500 patients he has treated for coronavirus symptoms are from Kiryas Joel, while the other 150 live in the Monsey area, where his second clinic is located. He said he has largely not had his patients tested for coronavirus, because he worried that waiting for test results to begin treatment would compromise the treatment's effectiveness.

Shlomo Polachek, the patient representative for Hatzalah, the Orthodox paramedic service, in Monroe, N.Y., which borders Kiryas Joel, said that the Hasidic community there has seen three hospital admissions: two on Monday afternoon and one on Saturday who was released within 24 hours.

"Here in Monroe, it seems to be an indication that it works for the people," Polachek said of Zelenko's experimental treatment. "It's hard to say for sure."

Trump has been pushing for broader use of hydroxychloroquine since last week. On Sunday he said the drug "would be a gift from heaven, this would be a gift from God if it works."

But the experimental use of the drug goes against public-health officials' more cautious approach. Fauci, a top doctor at the National Institutes of Health, suggested that he would only make the drug available under the auspices of a controlled clinical trial.

On Monday evening, New York Gov. Andrew Cuomo released an executive order that effectively ended pharmacists' ability to prescribe hydroxychloroquine for use in treating Covid-19, and prohibited any experimental use of the drug outside of state-approved clinical trials. On Tuesday morning, at a press conference, he said that New York hospitals would begin using the drug that day, after Trump had encouraged him to try hydroxychloroquine on patients already admitted to hospitals.

"He sent it to me, I'm using it, today," Cuomo said. "If it works, great."

Zelenko said the idea behind his approach is to treat the spread of the virus in the body before it damages the lungs beyond repair. Once the lungs of a Covid-19 patient exhibit what's called acute respiratory distress syndrome, according to WHO, the patient's likelihood of death is about 50%, according to early estimates.

His method is based on very rough data presented in recent studies. One, from China, found that hydroxychloroquine was effective at stopping the spread of the novel coronavirus in petri dishes. A study from France released last week, based on a sample size of 20 patients, suggested the combination of the drug with azithromycin, a common antibiotic, appeared to be helpful in lowering the amount of coronavirus the body, and therefore buying time to treat the disease.

{WRONG: The French study announced that its treatment CURED the disease - Peter M.}

However neither study was comprehensive or done in a controlled setting, which is why health officials have pushed back against the use of the drug. But Zelenko said that his method, despite being untested, is necessary, as health officials predict more than 1 million deaths across the United States. He said he believes it is safe, because so far he has recorded minimal side effects.

"It's a no brainer - in the right subset of patients," he said.

Already, public health officials in India and Jordan have authorized use of hydroxychlorquine for treating Covid-19. Some doctors in the U.S. are using the drug to treat the disease as well, as well as using it themselves to stave off infection as they treat coronavirus patients.

Trump has latched onto it as a "game changer" in fighting coronavirus as he pushes to reopen the American economy sooner than many health experts are advising. He wrongly stated last week that the FDA had approved the drug for treating the coronavirus. FDA Commissioner Stephen Hahn said the drug would only be available "in the setting of a clinical trial - a large, pragmatic clinical trial."

Zelenko said that he felt that hydroxychloroquine was not being taken seriously as a treatment due a combination of factors, including conservativeness on the part of the government's medical establishment in requiring a controlled clinical trial, as well as the fact that Trump himself has been pushing for the use of the drug.

"And this is a political year, with a presidential election, and there are forces at play that would prefer to see the economy collapse rather than President Trump to look good, in my opinion," Zelenko said.

Zelenko has already taken his message to Fox News commentator Sean Hannity's news program. On Monday evening, on his cable TV program, Hannity also read from a letter that Zelenko said he sent to Mark Meadows, Trump's chief of staff, and praised Zelenko's methods.

"I'm just blown away by all this," Hannity said in the radio interview.

Zelenko said that his regimen is also being studied by medical officials in Israel and Brazil.

He said that he has also been contacted by dozens of doctors interested in his regimen. One doctor who called him, Dr. Avery Knapp, a neuroradiologist with a practice in Florida, said that he realizes Zelenko's method is untested, but wants the government to investigate to see if his results are real.

"It seems to me to be a very interesting approach," said Knapp, who said he is not involved in treating coronavirus patients. "There's not a lot of US studies, but he's taking basically what a lot of hospitals are doing for inpatient, and he's taking it one step further, which is taking it to higher risk outpatients." ...

https://www.thegatewaypundit.com/2020/03/stunning-ny-doctor-vladimir-zelenko-finds-100-success-rate-in-350-patients-using-hydroxychloroquine-with-z-paks-video/

{video} STUNNING! NY Doctor Vladimir Zelenko Finds 100% Success Rate in 350 Patients Using Hydroxychloroquine with Zinc (VIDEO)

by Jim Hoft March 23, 2020

Over the weekend Dr. Vladimir Zelenko from New York state announced he has found a treatment against the coronavirus with a 100% success rate on 350 patients.

Dr. Zelenko joined Sean Hannity earlier today on his radio program to discuss the results from his test.

{see video}

The New York doctor also posted a video explaining his success with hydroxychloroquine and Zinc . His treatment resulted in the shortness of breath issue being resolved in 4 to 6 hours. Dr. Zelenko in his study had zero deaths, zero hospitalizations and zero intubations!

Later on Monday evening Sean Hannity invited two more medical experts on to discuss Dr. Zelenko's coronavirus results. The two doctors were cautiously optimistic.

Via Hannity:

We updated this post to note Dr. Zelenko used Zinc supplement and not Z-Paks in his treatement.

(20) CDC knew Chloroquine effective against Coronavirus since 2005; Class Action against CDC

https://www.breitbart.com/politics/2020/03/19/chloroquine-known-as-effective-against-coronavirus-since-2005/

Delingpole: Chloroquine Known as Effective Against Coronavirus Since 2005

James Delingpole

19 Mar 2020

The world economy is collapsing because of the terror and mounting death toll caused by the Coronavirus pandemic. But the anti-malarial drug chloroquine is effective both as a prophylactic and treatment for the virus ­ and the medical establishment has known about this since at least the SARS coronavirus outbreak in 2005. What the hell is going on?

Yesterday, I reported the existence of three studies, all claiming that chloroquine phosphate had proved effective in treating the COVID-19.

This has since been confirmed by a more recent open-label non-randomised clinical trial in France by Didier RTaolt M.D. / Ph.D et al, completed just days ago. The sample was small but the results were convincing.

As the summary reports:

100% of patients that received a combination of HCQ and Azithromycin tested negative and were virologically cured within 6 days of treatment.

In addition, recent guidelines from South Korea and China report that hydroxychloroquine and chloroquine are effective antiviral therapeutic treatments for novel coronavirus.

But the story gets more extraordinary still. It turns out that the Centers for Disease Control and Prevention (CDC) has known since at least 2005 that chloroquine is effective against coronaviruses.

In 2005, Martin J Vincent et al published a study in Virology Journal titled 'Chloroquine is a potent inhibitor of SARS coronavirus infection and spread.'

<https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69>

Here are its findings:

Background

Severe acute respiratory syndrome (SARS) is caused by a newly discovered coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently available. Results

We report, however, that chloroquine has strong antiviral effects on SARS-CoV infection of primate cells. These inhibitory effects are observed when the cells are treated with the drug either before or after exposure to the virus, suggesting both prophylactic and therapeutic advantage. In addition to the well-known functions of chloroquine such as elevations of endosomal pH, the drug appears to interfere with terminal glycosylation of the cellular receptor, angiotensin-converting enzyme 2. This may negatively influence the virus-receptor binding and abrogate the infection, with further ramifications by the elevation of vesicular pH, resulting in the inhibition of infection and spread of SARS CoV at clinically admissible concentrations.

Conclusion

Chloroquine is effective in preventing the spread of SARS CoV in cell culture. Favorable inhibition of virus spread was observed when the cells were either treated with chloroquine prior to or after SARS CoV infection. In addition, the indirect immunofluorescence assay described herein represents a simple and rapid method for screening SARS-CoV antiviral compounds.

It ought to be no surprise that chloroquine is effective against both SARS and COVID-19. After all, they are both coronaviruses and COVID-19 has often been described in medical and research sources as SARS-2.

Chloroquine works by enabling the body's cells better to absorb zinc, which is key in preventing viral RNA transcription ­ and disrupting the often fatal cytokine storm.

As at least one person has noticed, the implications of this are enormous. If the medical establishment ­ including CDC ­ has been aware of the efficacy of chloroquine in treating coronavirus for at least 14 years, why has it not been mass produced and made available sooner?

Given that CDC knows that Chloroquine/Hydroxychloroquine is an effective treatment for COVID-19 and a prophylactic against infection.

There are grounds for everyone that has suffered and the families of those who have died for a Class Action Law suit against the CDC

- Ian Wilson (@Le_Nautonnier) March 19, 2020

Here, you might have imagined, is the dream solution: a stop gap treatment for coronavirus which could save many lives and obviate the need for this global lockdown which is destroying our economies.

Why isn't the solution being shouted from the rooftops?

One possibility, as I suggested yesterday, is that there is no money in it for Big Pharma. Chloroquine is a generic drug. That's why Big Pharma's lobbyists have worked hard to persuade governments that there can be no acceptable solution till a patented vaccine is brought on to the market. Even if this happens it won't be till long after the pandemic is over ­ probably not till at least next year.

I don't think our businesses, our livelihoods, our sanity can wait that long. Do you?

(21) Vladimir Zelenko's success is a setback for CDC, MSM & Big Pharma which is developing a multibillion dollar vaccination program

https://www.globalresearch.ca/video-ny-doctor-vladimir-zelenko-finds-100-success-rate-350-patients-using-hydroxychloroquine-zinc/5707381

GR Editor's Note

This is a "potential" slap in the face to the CDC, the US media and Big Pharma which is developing a multibillion dollar vaccination program.

Big Pharma's intent -with the support of the Western media - is to suppress relevant information on the features of the virus and how it can be cured. Treatment is currently the object (in several countries including the US) of debate by virologists and physicians. Dr. Zelenko's treatment on the use of hydroxychloroquine is in this regard of utmost importance.

Michel Chossudovsky, Global Research, March 24, 2020

***

Over the weekend Dr. Vladimir Zelenko from New York state announced he has found a treatment against the coronavirus with a 100% success rate on 350 patients.

Dr. Zelenko joined Sean Hannity earlier today on his radio program to discuss the results from his test.

The New York doctor also posted a video explaining his success with hydroxychloroquine and Zinc. His treatment resulted in the shortness of breath issue being resolved in 4 to 6 hours. Dr. Zelenko in his study had zero deaths, zero hospitalizations and zero intubations!

Later on Monday evening Sean Hannity invited two more medical experts on to discuss Dr. Zelenko's coronavirus results.

The two doctors were cautiously optimistic.

END

(22) Peer-reviewed study of 2005 attests that Chloroquine inhibits SARS CoV

From: leo schmit <leoschmit@yahoo.com> Subject: Re: French Peer-Reviewed Study announces Cure for Coronavirus: HCQ + Azithromycin

Peter,

Here is another peer-reviewed study on HCQ of 2005! Apparently it has been on the shelf for 15 years. (I received this link through Tw)

https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-2-69

Conclusion

Chloroquine, a relatively safe, effective and cheap drug used for treating many human diseases including malaria, amoebiosis and human immunodeficiency virus is effective in inhibiting the infection and spread of SARS CoV in cell culture. The fact that the drug has significant inhibitory antiviral effect when the susceptible cells were treated either prior to or after infection suggests a possible prophylactic and therapeutic use.

Comment (Peter M.): That article from Virology is the basis for a possible Class Action against the CDC, for not preparing stocks of Chloroquine.

(23) Herbal remedies for Coronavirus: Quercetin, Coconut oil, Cinnamon, Ginger, Sage, Rosemary

From: Darren Cawley <d4rr3n_c@btinternet.com> Subject: Re: Prophylactic dose of Chloroquine or Hydroxychloroquine

Thanks Peter for all the excellent info.

I am taking Coconut oil as a preventative, I stir it into my coffee and drink it .

I addition I have brewed up an antiviral cocktail of herbs:

Cinnamon powder, Ginger Powder, Dried Sage, Dried Rosemary; Sweeten with molasses

Many of these herbs will actually destroy the HIV virus and we know this virus is similar

I also have 1000mg Quercetin tablets, its mode of functioning is the same as chloroquine, it causes inter cellular zinc levels to rise which makes virus replication difficult. The advantage is that Quercetin is cheap and you dont need a prescription to get it.

In addition I was looking for something that one could inhale to destroy the virus directly in the lungs so I have mixed Rosemary, lemon balm and cinnamon essential oil.

Fennel oil was found to reduce lung inflammation by over 80%, we know that lung inflammation is the major cause of death with this virus.

Coconut and COVID-19: Philippines studying antiviral properties of coconut oil as potential treatment

https://www.nutraingredients-asia.com/Article/2020/03/11/Coconut-and-COVID-19-Philippines-studying-antiviral-properties-of-coconut-oil-as-potential-treatment

The Philippines is looking to study virgin coconut oil (VCO) as a potential treatment for the novel coronavirus ...

Fennel Reduced Lung Inflammation by 86 Percent - Green Valley Natural Solutions

https://greenvalleynaturalsolutions.com/fennel-reduced-lung-inflammation-by-86-percent/

Volume 1: Issue #99 Fennel is a popular, tasty herb that chefs all over the world use to improve their entrees. ...

5 CoronaVirus Medication / Supplements for Treatment!

https://www.youtube.com/watch?v=vs0KPr-Ok0g

5 Medication / Supplements for Treatment! Summary No Randomized control trial to prove these medications / metho...

(24) Philippines study of Virgin Coconut Oil as remedy for COVID-19

https://news.abs-cbn.com/news/02/24/20/ph-looks-into-efficacy-of-coconut-oil-against-covid-19

PH looks into efficacy of coconut oil against COVID-19

Arianne Merez, ABS-CBN News

Posted at Feb 24 2020 03:57 PM

MANILA- The Philippines is looking into the efficacy of using virgin coconut oil (VCO) to treat the 2019 new coronavirus (COVID-19), a new strain that has affected thousands worldwide.

Cabinet Secretary Karlo Nograles said Monday the Philippines has tapped the National University of Singapore to test the oil's effectivity to combat the virus.

"We are now preparing sending samples of VCO {Virgin Coconut Oil} for testing within the week," he told reporters in Malaca- ang.

Over 78,000 have been infected with the COVID-19 which causes flu-like symptoms.

China, the global epicenter of the virus, has the most number of cases at 77,000 followed by South Korea which has over 600 cases.

Using coconut oil as a possible antiviral agent against COVID-19 was first studied by Dr. Fabian Dayrit of the Ateneo de Manila University, and Dr. Mary Newport of Spring Hill Neonatolody, Inc. in their research titled "The Potential of Coconut Oil and its Derivatives as Effective and Safe Antiviral Agents Against the Novel Coronavirus (nCoV-2019)" published on Jan. 31, 2020.

The study proposes an extensive research on the potential of coconut oil as a safe agent against COVID-19 given that it has significant amount of lauric acid which contains elements that have shown to have "potent antiviral properties."

It added that coconut oil and its derivatives have been shown to be "safe and effective antiviral compounds in both humans and animals."

"Given the considerable scientific evidence for the antiviral activity of coconut oil, lauric acid and its derivatives and their general safety, and the absence of a cure for nCoV-2019, we urge that clinical studies be conducted among patients who have been infected with nCoV-2019," the study stated.

"This treatment is affordable and virtually risk-free, and the potential benefits are enormous," it added.

The Philippines at present has no confirmed cases of COVID-19. It earlier confirmed 3 cases, all foreign nationals who came from the Chinese City of Wuhan. One of the patients died but the 2 others have since recovered.

(25) Nevada prohibits prescribing CQ HCQ

From: "Liliana_Dumitrescu" <marquisdeart@embarqmail.com> Subject: Re: Prophylactic dose of Chloroquine or Hydroxychloroquine

Gov. Sisolak signs emergency regulation restricting drug distribution during COVID-19 Posted: 3:48 PM, Mar 24, 2020 Updated: 3:59 PM, Mar 24, 2020

LAS VEGAS (KTNV) - Gov. Steve Sisolak signed an emergency regulation today related to the prescription of two drugs that some are saying may help patients with COVID-19.

While the drugs serve necessary medical purposes, there is no consensus among COVID-19 experts or Nevada's own medical health advisory team that the two drugs provide treatment for COVID-19 patients. The emergency regulation is aimed at preventing hoarding of the drugs.

"This emergency regulation protects Nevadans who needs these drugs for legitimate medical purposes. At this point in time, there is no known cure for COVID-19 and we must not withhold these drugs from those who need them," said Gov. Steve Sisolak.

"The best way to prevent the spread of COVID-19 is to stay home for Nevada, not to stockpile these drugs."

The regulation prohibits the prescribing and dispensing chloroquine and hydroxychloroquine for a COVID-19 diagnosis, requires an ICD-10 code on prescriptions for the drugs and limits the prescription amount to a 30-day supply for the drugs.

The emergency regulation will ensure access for Nevada patients to chloroquine and hydroxychloroquine for legitimate medical purposes.

"This emergency regulation is a strong step in protecting patients. While studies are underway on the usefulness of these drugs in treating COVID-19, we must deal with facts, not fiction," said Dr. Ishan Azzam, the chief medical officer for the state Division of Public and Behavioral Health. "Preserving these drugs for those who need it is the right decision."

(26) Quercetin, Inflammation and Immunity

From: Stanley Young <stanjyoung@sbcglobal.net> Subject: Re: Herbal remedies for Coronavirus: Quercetin, Coconut oil, Cinnamon, Ginger, Sage, Rosemary

Peter, Thanks so much for all your work and for relaying what all you find. Re Quercetin, I found this from a gov't. site which is very favorable but of course no in-depth studies have been done since it's not funded by Big Pharma:

Quercetin, Inflammation and Immunity

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808895/

Quercetin, Inflammation and Immunity

See this in the Abstract: "In vitro and some animal models have shown that quercetin, a polyphenol derived from plants, has a wide range of biological actions including anti-carcinogenic, anti-inflammatory and antiviral activities ... ". [emphasis added]

Stan Y.

P.S. I should add that I'm apparently not a good candidate for chloroquine and hydroxychloroquine since I read that people with "retinopathy" shouldn't use them and in reading abt. that condition one of the symptoms is if you have "floaters" in the visual field, which I have had since childhood; thus the interest in alternative natural remedies. Apparently, if I were to use a lot of the above 2, it could lead to blindness. Doubt that would occur with quercetin, though.

Reply (Peter M.): Stan, I have had "floaters" for the last few years (I'm getting old); but I'm taking Chloroquine. My tablets are 40 years old; I'm one of those people who does not throw out old medicines. I don't pay much attention to "use by" dates.

I'm taking 2x 250mg tablets once a week. But on day 2 I took an extra 2, because there's a delayed effect. This dose is similar to that recommended by the Government of India for HCQ to prevent Covid-19. Knowing this dosage allows me to self-medicate with confidence; otherwise I might have taken too much. The dosage to fight Covid-19 after you get it is much higher.

In 1980, after a visit to Papua New Guinea, I began getting big boils on my legs. A government lab could find nothing. Antibiotics would get rid of them for a while, but they kept coming back. Finally, a GP in my home town (Sheffield, Tasmania), sent a specimen to a different lab, a private one, and the result came back - Bubonic Plague. A rat had bitten me on the toe, one night, in the Highlands.

The lab found that only one antibiotic would kill it - Gentomycin. But there were possible adverse side-effects - to my hearing or sight, can't remember which. Anyway, I took the Gentomycin, the boils went away, and those side-effects have not yet happened. I still have a hollow on one leg, where the biggest boil was.

I was told that my blood would be worth bottling - because it had antibodies to the plague.

I'm not suggesting that you try the CQ or HCQ. But I eat plenty of Bitter Melon (in stir-fries) when it's bearing, without noticeable side-effects, and it contains quinine compounds.

I take herbal medicines for my Prostate: Stinging Nettle Root powder (1/2 tsp a day), and Prosta Response, from Source Naturals, one tablet a day. It's an expensive tablet, but it contains lots of ingredients, including Quercetin. The recommended dose is 2 tablets, but I take only one, on an empty stomach, first thing in the morning.

(27) Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728566/

Wenjiao Wu,1 Richan Li,1 Xianglian Li,1 Jian He,1 Shibo Jiang,2,3 Shuwen Liu,1,* and Jie Yang1,2,*

Wenjiao Wu

1 State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

2 Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY 10065, USA; nc.ude.naduf@gnaijobihs

3 Key Lab of Medical Molecular Virology of Ministries of Education and Health, Shanghai Medical College, Fudan University, Shanghai 200032, China

Here we found that quercetin inhibited influenza infection with a wide spectrum of strains ... Mechanism studies identified that quercetin showed interaction with the HA2 subunit. Moreover, quercetin could inhibit the entry of the H5N1 virus using the pseudovirus-based drug screening system. This study indicates that quercetin showing inhibitory activity in the early stage of influenza infection provides a future therapeutic option to develop effective, safe and affordable natural products for the treatment and prophylaxis of IAV infections. ==

(28) Quercetin is a plant pigment (flavonoid) found in brightly-coloured fruits & veg

https://www.webmd.com/vitamins/ai/ingredientmono-294/quercetin

Quercetin is a plant pigment (flavonoid). It is found in many plants and foods, such as red wine, onions, green tea, apples, berries, Ginkgo biloba, St. John's wort, American elder, and others. Buckwheat tea has a large amount of quercetin. People use quercetin as a medicine.

Quercetin is most commonly taken by mouth to treat conditions of the heart and blood vessels and prevent cancer. It is also used for arthritis, bladder infections, and diabetes. But there is limited scientific evidence to support these uses.

Quercetin has antioxidant and anti-inflammatory effects which might help reduce inflammation, kill cancer cells, control blood sugar, and help prevent heart disease.

Comment (Peter M.): When it says, "Quercetin is a plant pigment", this means that it found in brightly coloured (eg red or purple or yellow) fruits & vegetables. "Red wine" means Black Grapes; "onions" means Red / Purple Onions. "Apples" means Red Apples. Red Capsicum and Yellow Capsicum would also contain Quercetin. Also bright red or yellow tomatoes, and Blackberry, Cranberry and Blueberry fruits.

However, you might need to eat a lot of fruits to get enough Quercetin. It may be easier to buy a supplement.

(29) Ministry of Truth (Globalist MSM) brand Didier Raoult's Chloroquine cure 'Fake News'

https://www.rt.com/op-ed/484102-raoult-chloroquine-coronavirus-treatment/

This scientist suggested a drug to treat Covid-19. 'Fact checkers' branded him fake news

Nebojsa Malic is a Serbian-American journalist, blogger and translator, who wrote a regular column for Antiwar.com from 2000 to 2015, and is now senior writer at RT. Follow him on Twitter @NebojsaMalic

Mar 26, 2020

Amid a pandemic panic over the coronavirus, evidence for a possibly effective treatment has been denounced as 'fake news' ­ even when offered by a renowned scientist with decades of experience.

Take Didier Raoult, a French microbiologist with undeniable expertise, even if some of his views are about as eccentric as his appearance. Though he may look like he just stepped out of an Alexandre Dumas novel, the director of the Mediterranean University Hospital Institute in Marseille cited not one but three different studies from China showing that the anti-malaria drug called chloroquine has been effective in treating Covid-19 patients.

#chloroquine Pr Didier Raoult : «C'est quand les patients ont des formes modérées, moyennes, ou qui commencent à s'aggraver, qu'il faut les traiter. A ce moment là on contrôle les virus qui se multiplient. Quand ils sont rentrés en réanimation, le problème ce n'est plus le virus» pic.twitter.com/WolGe2o05z - Alex (@AlexLeroy90) March 25, 2020

That did not stop Le Monde, France's biggest newspaper, of declaring his February 25 video as "partially false." Raoult's 'sin' was to argue that the common anti-malaria drug used widely for decades resulted in "dramatic improvements" among those afflicted by the virus.

As a result of Le Monde's fact-check, anyone attempting to share Dr. Raoult's videos on Facebook gets a banner saying the information therein was "partially false" as "determined by independent fact-checkers."

The main argument put forward by those critical of the drug is that more testing is required before it can be officially approved as treatment for the coronavirus. As the US Centers for Disease Control and Prevention (CDC) puts it, "There are no currently available data from Randomized Clinical TrialsÉto inform clinical guidance on the use, dosing, or duration of hydroxychloroquine" treatments for Covid-19.

Which is fair enough, but last time I checked, there was a pandemic going on, with billions of people locked in their homes and all business grinding to a halt across the globe, over apocalyptic predictions of hospitals brimming with corpses due to this coronavirus.

Should any kind of treatment ­ especially a drug that has been used safely for decades to treat something else, with side effects meticulously documented ­ be so cavalierly rejected, under the circumstances? Do "experts" really think the world has the luxury of waiting for months or even years for their controlled lab studies?

As for the fact-checkers, shouldn't they have applied the same rigor to the models used to scare everyone into hoarding toilet paper and setting off a depression orders of magnitude worse than anything the world has ever seen?

To ask these questions is to answer them, yet no one seems to bother. Nor is this sort of selective blindness endemic to France; across the Atlantic, the mainstream media raised their voices in unison against chloroquine after US President Donald Trump brought it up as a possible treatment ­ apparently referring to Dr. Raoult's work.

They went so far as to widely circulate a deliberately misleading story about an Arizona couple that ate fish tank cleaner ­ chloroquine phosphate, clearly labeled not for human consumption ­ as somehow Trump's fault. Some of them quietly amended it to specify the difference, but long after the original story ­ implying they took the actual medication praised by the president ­ literally went viral and poisoned the minds of millions.

Worse yet, as a result of this media blitz, the governor of Nevada actually banned using chloroquine to treat Covid-19 patients this week, saying there was "no consensus among experts or Nevada doctors" that the anti-malaria drug can treat coronavirus sufferers. There were no angry editorials denouncing Steve Sisolak, a Democrat, for letting people die or the coronavirus rather than have them treated with a drug endorsed by the Republican president and the media's favorite hate object.

One would think the world paralyzed with fear of the invisible death would pounce on every possible solution, no matter how unlikely it seems. That's what we're shown in Hollywood disaster movies, after all. Yet when such a solution presents itself, it is dismissed and denounced as "not proven"!

We're supposed to blindly trust apocalyptic models produced by panic-mongering political hacks, but ignore the man who says the drug brought him back from the brink of death, even though his story can be easily verified and theirs cannot.

"Preferring opinions to facts is a disease," Dr. Raoult told the French magazine Marianne last week. Just so.

I don't know if hydroxychloroquine works on Covid-19. Dr. Raoult seems to believe so, and he's not alone. In the absence of better solutions ­ and locking billions of people in their homes indefinitely is not one ­ don't we owe humanity to at least try? What do we have to lose?

In the three months or so since the coronavirus first appeared in China, there has been a lot of conflicting, confusing and outright false information about it. One thing that has consistently proven true, however, is that the biggest obstacle in effectively battling its spread and treating the afflicted has been the obtuse insistence of the political and medical establishment on blindly following their rules. If the virus is truly threatening to kill millions, as they say, they would not value procedures over saving lives. Nevertheless, they persist. It makes one wonder why.

(30) Recovery at Home - from Death's door in 4 days of natural therapies - Dr David Brownstein

by Peter Myers, March 30, 2020.

If my recent newsletters seemed alarmist, this one will be calming.

Dr David Brownstein is a practitioner of holistic medicine, who operates a website and newsletter. He uses vitamins rather than herbs, but not drugs as per Big Pharma.

He says that the media are over-hyping the virus, and that "we should quarantine the sick and let the healthy get back to work." This sound like Trump's solution.

I disagree; I think that China has shown the way. Strict quarantine and social distancing stop the transmission of the virus; after a couple of months, normal life can gradually resume.

Anyway, Dr Brownstein and Dr Ng seem to have had good success with their methods of preventing and treating Covid-19. They recommend home treatment rather than going to hospital.

Apart from vitamins, they recommend use of a Nebulizer. I had never heard of such equipment, but it seems to be a machine used by asthmatics to aerate their lungs. I gather that it would be the home equivalent of a Ventilator. You can buy them at pharmacies, and also on eBay.

{added April 24, 2020: This youtube explains how to use a Nebuliser: https://www.youtube.com/watch?v=KeCLig08LEk }

I'm going to investigate whether I can use antiviral essential oils (Cinnamon, Ginger, Sage, Rosemary) in a Nebulizer to directly kill the virus in my lungs, should it get that far. If any reader knows how to use a Nebulizer, or the recipe for using essential oils in one, please let me know.

Spending a few hundred dollars would be cheap, if it saved one's life or that of other people.

{added April 24, 2020: Essential oils might clog the Nebuliser; but I have found a way: you need a 5ml bottle / viall of each of Lemon Balm oil, Rosemary oil, Cinnamon oil, and Fennel oil; and a bigger bottle which has a nose dropper in its lid. Tip the four essential oils into the bigger bottle, and shake. If you don't have all four, use the ones you've got. Then, using the dropper, place one drop of the mixture at the bottom of each nostril. It stings a bit at first, but only for a moment. Do not use too much - half a drop per nostril would do. You will then inhale the mix. Shake before using, each time - Peter M.} ==

Recovery at Home - from Death's door in 4 days of natural therapies

The video below could save your life. It's a discussion between Dr. David Brownstein, a practitioner of Holistic Medicine, and a patient called Christopher, who recovered at home in four days.

Remember that hospitals are death-traps at present, and the staff are stretched to breaking point. Home treatment can save both you and them.

Dr Brownstein and Dr Ng advise against taking Panadol (Tylenol) or Ibuprofen if you get a fever; they will make your condition more serious. Don't try to suppress the fever; it is nature's healing process, the hotter the better.

They said that conventional medicine has no answer for this virus.

https://www.youtube.com/watch?v=YYiFuWa5ito&feature=share

christopher video 1

29 Mar 2020

Dr. David Brownstein

"......4 days ago I felt like I was staring at inevitable death....."

This is the statement made by Dr Ng's patient, Christopher, who had tested positive for COVID-19. This is one of the worst cases we have seen at CHM. Christopher was sick for nearly 2 weeks, with a high fever, body aches, chills, nausea, and diarrhea.

He even took Tylenol {Panadol} and Ibuprofen, with hopes that it would give him some relief from the fever and pain. This only worsened his condition.

Thankfully, Christopher is recovering after 4 days of natural IV therapies and a supplement protocol administered by Dr Ng. This pandemic is real, but so are the results of natural therapies. Watch Christopher's testimonial on he recovered from COVID-19.

https://www.drbrownstein.com/coronavirus-vii:-we-are-ready-and-you-can-be-ready-too!-2

Dr B's Holistic Medicine

Coronavirus VII: We Are Ready and You Can Be Ready Too!

Mar 11 2020

My partners (Dr. Nusbaum, Dr Ng, Taylor Eason, NP & Jenny Drummond, PA) have all found success using natural therapies to enhance the body's immune system as well as to kill viruses including flu-like viruses. Today, I ordered intravenous hydrogen peroxide, vitamin C, ozone, and glutathione for my sick patients. I am confident these therapies will help them recover uneventfully. Keep in mind my partners and I have nearly 80 years of experience with these therapies! Not only do they work, they can be miraculous. Just ask our patients!

Intravenous nutrient therapies are wonderful treatments, but there are other oral natural therapies that are effective against viral infections including coronavirus. Vitamins A, C, and D along with iodine have proven benefit. At the first sign of any illness, I suggest my patients take 100,000 U of vitamin A (NOT beta-carotene), 50,000 U of vitamin D3 and 5-10,000 mg of vitamin C per day for four days. Pregnant women should not take high doses of vitamins A and D. Vitamin C can be increased to bowel tolerance.

What else can you do? It is important to eat a healthy diet free of refined sugar, salt, oils, and flour. And, perhaps the most important thing is to maintain optimal hydration. That means taking your weight in pounds, divide the number by two and the resultant number is the minimum amount of water to drink in ounces per day. I cannot stress the importance of drinking optimal amounts of water. ==

Dr Brownstein and Dr Ng recommended home treatment

Dr Brownstein and Dr Ng recommend home treatment consisting of

- vitamins (A, C, and D). I did not buy D, because we have lots of sunshine here, and there is some issue with D and ACE2 receptors (see item 3).

- iodine solution to be taken internally (just a drop or two), and hydrogen peroxide.

- a Nebulizer. I rushed out and bought the last one at our local pharmacy; more stocks arrive tomorrow.

I also bought vitamin A tablets, Vitamin C powder (sodium ascorbate; it was all they had), iodine solution for internal use, and hydrogen peroxide.

They took cash, but said that in future they might only accept cards. They had lanes marked on the floor to keep customers apart from each other and from staff. Customers were not allowed to touch products before purchase. The staff wore gloves. One, at the front door, took my temperature as I came in; she wore a mask, but there were not enough masks for the other staff. ==

Dr David Brownstein answers Questions on his treatment for Covid-19

https://www.drbrownstein.com/coronavirus-xii:/

Questions ? Call 248-851-1600

Mar 22 2020

Coronavirus XII: There Is Good News

David Brownstein, M.D.

Comments ( 165 )

Penelope Miller

27 Mar 2020

Question Dr B, I started coming down with what I hope is a cold (runny nose, cough and headache) I upped my does of A,D an C for the 4 days I'm back down to maintenance level as of today. I'm not getting better. What can i do to get rid of this and when should I worry this is not a cold? As alway you are awesome Dr B

Reply 27 Mar 2020

Penny-Lope, As my patient, I can give you medical advice. Take iodine along with it. At least 50 mg/day. Also, you can another round of the higher dosed vitamins for four days. Also, avoid sugar in the diet, keep hydrated and take a bath with Epsom salts twice per day or go in a sauna. Worrying does not help a thing. People still get colds! And, keep up with vitamin C. Keep me posted on how you are doing, DrB

Angela 26 Mar 2020

Would you please post directions for Lugol's + saline in Neti pot, as well as when to use the Lugol's vs straight saline for nasal rinse.

How many times weekly for each?

I recently switched to a Neil Med nasal flush ­ (the solution reaches a bit higher & is more sanitary (I switch out the bottle monthly).

Reply 28 Mar 2020

Angela, For my patients, I recommend 1/4 teaspoon of unrefined salt and 1-2 drops of Lugol's 5% {Iodine} solution in a nettipot. Drain the sinuses twice per day and more if sick. DrB

Pauline Schwedt 25 Mar 2020

Question Dr. B, a co-workers wife just tested positive for Covid19, I haven't had contact with him in a week, should I as a precaution up my A,C,D and iodine?. I have no sympotms just my normal seasonal allergies, also Fred, should he as well and should we "self quarentene" . I'm more worried about exposing my 94 yr old mother inlaw and Fred, not to mention the people we drive on public transit. Thanks Dr. B your awesome

Reply 25 Mar 2020

HI Patient Pauline, I would take the supplements at the higher doses for 4 days, then lower them down to maintenance again. DrB

Priscilla Pillsbury 25 Mar 2020

The novel Coronavirus, Covid19, is not similar to the ordinary "flu". This virus is a RETROvirus, meaning it begins as an RNA virus, but it sequence morphs in to a variant of a DNA Virus. This happens during the shedding process where vast proteins break open to reveal the nucleic core of the virus, them massively duplicates itself. Aids ( HIV ) was our last pandemic retrovirus. Was that simple to eradicate? to cure. Your very DNA is altered. In addition to that, scientists do not yet have a handle on the protease involved, and the exact engineering mechanisms which means we can not AT ALL anticipate how this thing will play out. How and when it will morph. Also, to suggest that if you get this thing once you will have permanent immunity is false. China is already experiencing boomerang whiplash in re contagion. This thing is closer in nature to SARS and HIV than a common flu, which is why the "cures" will be variants on the drugs that were employed for those viruses. Does this mean we should not immerse ourselves in natural healing methods. No. Now more than ever we need to arm ourselves and create strong shields. There are many natural protocols that are effective from Astragulus to Curcumin. Immunity is keyÉ.. But AVOIDANCE is far and away #1É.again, we con not predict the future. And viruses are stealth bombs. Like Chicken Pox which can reemerge years later as shingles, we may catch this now and experience mild symptoms, but viruses go deep, hide and re emerge. Into what we don't know. I am happy and proud to shelter in place.

Laurasindoni@yahoo.com 25 Mar 2020

Urgent! Are you supposed to take the vitamin dosing for first sign of illness all at one time? I have a sore throat. Do I take 100,000 mg vitamin A, 50,000 D3 and 10,000 vitamin C all at once or space it out during the day? Thank you.

Reply 25 Mar 2020

L, I have my patients take it at the first sign of illness, for 4 days. All at once is ok, however, if possible, I tell my patients to space out the Vit. C a little bit. DrB

Laurasindoni@yahoo.com 25 Mar 2020

Lugols Iodine drop taste terrible even diluted with water. What can one do to tolerate the taste and upset stomach feeling?

Reply 25 Mar 2020

Laura, I will throw that out to the readers. Folks?? DrB

Nicolette T Konas 25 Mar 2020

Hi, my cousin puts her Lugols in grape or cranberry juice. I put mine in tea. Or sometimes just snarf it down in water. Na zdrowie!!!

Dave 25 Mar 2020

I put 12 drops of 2% lugals in my coffee and I can't taste it. I could with water however. If you don't drink coffee, perhaps a strong tea would mask the taste.

FS 26 Mar 2020

I've got a friend that puts it in juice and says he can't taste it. Personally, I mix my powdered buffered vitamin c powder with it and I cannot taste it. There's also tablet form as wellÉ Iodoral 12.5 mg tablets.

Laurasindoni@yahoo.com 26 Mar 2020

Dr, Brownstein, does the Iodine supplement change during signs of acute illness if you do not have a thyroid? Does it serve any other purpose when ill? Thank you.

Reply 26 Mar 2020

Laura, Yes. I say double or triple the dose during an acute illness like COVID. Of course, check with our iodine-knowledgeable doc. DrB

Laurasindoni@yahoo.com 27 Mar 2020

Dr. Brownstein, I am on day 3 from my illness and doing the vitamin dosing and I feel so much better! Is that when it usually starts to help? CuriousÉ

Reply David Brownstein, M.D. 27 Mar 2020

Laura, Made my day!!! It usually helps from 24-72 hours after starting. DrB

Timnah 24 Mar 2020

Hi Dr. B! I love your blogs, super rational & reassuring. I've been mulling something overÉfrom what I gather this virus is heat sensitive. Would using infrared heat (like a quality infrared heating pad) on the lung area for periods thorough out the day possibly have benefits? I know views of heat can seesaw because it also causes inflammation.

Reply 24 Mar 2020

T, Infrared heat, if the temp is high enough, could kill the virus. The problem is getting the temperature high enough without harming the body. DrB

Julie 26 Mar 2020

This virus arrived in Australia at a time of soaring temperatures. It is still hot, and the number of cases is growing daily. A large number of countries affected have hot climates, so I don't much trust in the theory that it will improve come summer.

George 24 Mar 2020

You propose large quantity of vitamin C but others mentions that Vitamin-C is an antioxidant and could certainly provide a boost to your immune system. But too much, could become pro-inflammatory and actually poke holes in your natural defenses to viruses and can have the opposite effect than what many believe. Is this true and how can we go about making sure we are using the right amount without the damage

24 Mar 2020

George, You need both oxidants and antioxidants for the immune system to function optimally. Vitamin C and iodine stimulate both antioxidant and oxidant pathways. DrB

Mirko 23 Mar 2020

Dear Dr., In animal studies, vitamin D increased the expression of ACE2. Increasing ACE2 could theoretically make it easier for the coronavirus to hijack the protein and gain entry to the cell. What do you think about that?

Reply 23 Mar 2020

Mirko, A rat study found vit D did indeed increase ACE 2 receptors. However, when vitamin D was given with LPS (which causes cytokine storm in the lungs), vitamin D when given with LPS {lipopolysaccharide} was found to result in a significantly lowered the negative effects in the lungs compared to the LPS group. That's what I think. DrB

Mirko 23 Mar 2020

Dear Dr., Thank you for being our lighthouse in this dark times ?? I thought iodine is to strong to be nebulized in the lungs. When you say that you put 2 drops of 5% Lugol's in 3cc normal saline for nebulizing, what do you mean in how much water you put 2 drops?

Reply 23 Mar 2020

Mirko, 1-2 drops of Lugol's IN 3 cc of normal saline. No water. In normal saline. DrB

Mirko 24 Mar 2020

Sorry to ask, but saline is water mixed with salt or saline is something else? Thanks

Reply 24 Mar 2020

Mirko, It is water and salt mixed. DrB

Kinabru 23 Mar 2020

Dr. B I know you highly recommend Vit. D, and i am taking it. I have been reading about ACE 2 receptors: Vit D increases ACE2 receptors in lungs-but has been shown to prevent damage by LPS (from bacteria), so it has that protective effect. BUT, C19 uses ACE2 receptor to enter and kill lung cells, so it could go either way. Any thoughts.

Reply 23 Mar 2020

Kinabru, I find it hard to believe I have been using high doses of Vit. D for over 20 years and seeing positive effects with viral illnesses. I have seen the articles as well. The rats did better with vitamin D. My patients are not doing worse with it. DrB

Sheva 23 Mar 2020

Mandatory vaccinations will breeze through legislation after this. Won't be able to enter the country without proof of vaccination.

Linda 23 Mar 2020

Dr. Brown, I have a strong background in the health sciences and a daughter who has a strong knowledge background around trauma, anxiety, stress, and the immune system. One thing we are aware of is the threat of anxiety and fear to our immune system and the inflammatory response. I do feel that the biggest threat to the world is fear and stress not just of the virus but the increase vulnerability of the basic needs of life. Core needs of a living organism are oxygen (breathe work), water, food, movement, shelter, and belonging (love, protection, herd immunity, purposeÉ). I may have missed something. As a faith based person that to me connects me to something bigger as well. Thoughts?

Linda 23 Mar 2020

I do feel that the biggest threat to the world is fear and stress not just of the virus but the increase vulnerability of the basic needs of life. Core needs of a living organism are oxygen (breathe work), water, food, movement, shelter, and belonging (love, protection, herd immunity, purposeÉ). I may have missed something. As a faith based person that to me connects me to something bigger as well. Thoughts?

David Brownstein, M.D. 23 Mar 2020

Linda, YOU GO! AGREE! The cure­quarantining for us all­may be worse than the disease. I have felt that from the beginning. We should quarantine the sick and let the healthy get back to work. DrB

Kathy 22 Mar 2020

I am working in a hospital setting that is quickly filling up with Covid patients. I am hopeful that Chloroquine may be an effective drug. I read that Quercitin and Epigallocatechin (plant based supplements) work in the same way. Any thoughts? Im considering having them on hand since I am definitely high risk.

Reply 23 Mar 2020

Kathy, Let's hope the drugs pan out. Take your vitamins!! My patients are doing well! DrB

Lawrence 22 Mar 2020

Hmm,..ok for you guys in Northern hemisphere, we in southern hemisphere, [NZ] are just heading into winter as this is hitting here. I have a OMRON Nebuliser on the way as I am 68 with prostate cancer, Graves disease, and compromised lungs. how does one use Iodine in a nebuliser?,..with Lugols? I am planning to investigate using seasalt, sodium ascorbate in nebuliser. Unfortunately we dont have any Health practioners up to speed with your work here in NZ as far as I know

Reply 23 Mar 2020

Lawrence, Suzanne Humphries, MD is in New Zealand. She can help guide you. There has to be others­I hope! DrB

Cindy 22 Mar 2020

I keep hearing about inhaled hydrogen peroxide as a course of treatment if your lungs become affected. What is your take on this potential protocol? Is there a best way to administer this?

Reply 23 Mar 2020

Cindy, It is a great treatment for lung problems­a lot more effective and cheaper than what the hospitals are doing. It is best to work with a holistic doc on this one. DrB

Jacob Bastomski 22 Mar 2020

At what concentration should 3% hydrogen peroxide be used and at what concentration should Lugol solution be used with respect to using these items in a nebulizer? And for how long and how often if one is first starting to express symptoms of a respiratory infection?

Reply 23 Mar 2020

Jacob, This should be done with the guidance of a holistic doc. . The hydrogen peroxide we mix at the office. Don't use over-the-counter H202 for this. DrB

Nicole 22 Mar 2020

The prospect of facing 3-18 months of life like this is scarier to me than a virus. The Los Angeles County Department of Public Health has advised doctors to only test patients for the coronavirus if a positive result would actually impact their treatment.

Carol 22 Mar 2020

Thank you for being a voice of reason during this strange time. I do have two question, why so many deaths in Italy? They say that the numbers are rising there? And you have mentioned taking vitamin A but not from beta carotene. So what kind do you recommend? Thanks!

Reply 23 Mar 2020

Carol, Italy was not prepared for this and started slowly­like we did. They also have a much older population. There may be another issue with Italy, but I am researching that now. Yes, vitamin A has the anti-viral effects, not beta carotene. Vitamin A from palmitate is my favorite choice. DrB

A B 23 Mar 2020

Italy has a lot of smokers. Smoking increases ACE -2 receptors which are the receptors coronavirus binds to.

See: https://www.mdpi.com/2077-0383/9/3/841/htm

Jean 24 Mar 2020

Got this from Dr. Michael Murray ...

"Could a new flu vaccine be partly responsible for the COVID-19 mortality rate in Italy?

In case you are not aware, the infection rate mortality rate in Italy to COVID-19 is dramatically higher. Why? Well the standard answers of an elderly population and the failure to implement social distancing soon enough just don't explain what is happening. My colleague, Dr. Alex Vazquez, provided me with a valuable insight. In September 2019, Italy rolled out an entirely new type of influenza vaccine. This vaccine called VIQCC is different than others. Most available influenza vaccines are produced in embryonated chicken eggs. VIQCC, however, is produced from cultured animal cells rather than eggs and has more of a "boost" to the immune system as a result. VIQCC also contains four types of viruses ­ 2 type A viruses (H1N1 and H3N2) and 2 type B viruses.2 It looks like this "super" vaccine impacted the immune system in such a way to increase coronavirus infection through virus interference that set the stage for what happened in Italy." Jean

Reply 25 Mar 2020

Jean, I have seen this as well. Let's see how it plays out. DrB

Linda 28 Mar 2020

Hi Dr Brownstein: Thank you for your blog. If adding Iodine to a nebulizer what form of Iodine do you use? is SSKI okay to use? how much? is it okay to add to my glutathione nebulizer? thanks again for your input.

Reply 28 Mar 2020

Linda, For my patients, I recommend using Lugol's 5% for nebulizing. SSKI will not have a viricidal effect. I also have had patients nebulize glutathione. DrB

(31) Nebuliser on the cheap: A USB ultrasonic mister for Essential Oils

From: Darren Cawley <d4rr3n_c@btinternet.com> Subject: Re: Recovery at Home - from Death's door in 4 days of natural therapies - Dr David Brownstein

Hello Peter,

I am not an expert in use of essential oils so this is just what I am doing. I selected essential oils that were not only antiviral but had been found to destroy specifically the HIV virus. Rosemary, Lemon balm and cinnamon. I mixed these in equal parts with fennel essential oil which has been found to reduce lung inflammation. I do not use an expensive nebuliser, I use a cheap USB ultrasonic mister which fits on the end of a bottle (example link below). I simply add some of the essential oil mixture into the water bottle and give it a good shake. Put this in your room next to your bed and as you breath in the air the antiviral oil will also be inhaled.

<https://www.ebay.com.au/itm/Portable-Car-Air-Humidifier-Diffuser-Ultrasonic-Aroma-Mist-Purifier-USB-Charging/274322379667?hash=item3fdee35393:g:icAAAOSwTthegbwd> Portable Car Air Humidifier Diffuser Ultrasonic Aroma Mist Purifier USB Charging | eBay

$21.29 Portable Car Air Humidifier Diffuser Ultrasonic Aroma Mist Purifier USB ...

Spray amount: 30-40ml/Aroma Diffuser Humidifier. Occasion: Working, Driving, Yoga, Reading, Sleeping, Traveling,... ==

I mixed all four oils together in equal parts and put it in a small bottle. I added a teaspoon of this oil to about 1 litre of water and give it a good shake.

I currently do not have the virus so I just have this ready if I get it and start to experience lung infection. I intend to let the antiviral mist fill the air around my bed which I will naturally inhale.

> Do you run it from a computer?

No I have a USB plug adaptor which is off an old phone charger.

> Does it have filters?

No it has a felt wick like in a felt-tip pen which it uses to draw up the liquid into the ultrasonic head.

> Do any of these essential oils clog up the system? What can be done about that?

I had it going for a few hours to test it and had no problem with clogging but as these USB misters are inexpensive I purchased three anyway. You can also have more then one running if you want a greater amount of mist.

This is not the only way to get the oil into the air, you could use one of those candle essential oil warmers.

I prefer the idea if having the air in the room impregnated with the antiviral oil rather then having a mask stuck to my face pumping it down my lungs.

{added April 24, 2020: I tried using an aromatherapy diffuser, with about 5 drops of essential oil per 100ml of water, but I could hardly smell the oils at this dilution. I have found an alternative: you need a 5ml bottle / viall of each of Lemon Balm oil, Rosemary oil, Cinnamon oil, and Fennel oil; and a bigger bottle which has a nose dropper in its lid. Tip the four essential oils into the bigger bottle, and shake. Tip the four essential oils into the bigger bottle, and shake. If you don't have all four, use the ones you've got. Then, using the dropper, place one drop of the mixture at the bottom of each nostril. It stings a bit at first, but only for a moment. Do not use too much - half a drop per nostril would do. You will then inhale the mix. Shake before using, each time - Peter M. }

(32) Turmeric in demand as a remedy for Coronavirus

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852989/

Role of Curcumin in Disease Prevention and Treatment

Published online 2018 Feb 28. ==

https://ncbi.nlm.nih.gov/pmc/articles/PMC5664031/

Curcumin: A Review of Its Effects on Human Health

Published online 2017 Oct 22. ==

https://www.ncbi.nlm.nih.gov/pubmed/23847105

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.

Epub 2013 Jul 12.

https://www.indiawest.com/news/global_indian/turmeric-is-being-touted-as-an-effective-herb-to-keep/article_6f3b697c-633e-11ea-8dd0-930267c416fd.html

Coronavirus scare shoots up demand for India's raw turmeric ... -march 13 2020

Olive Leaf extract plus Turmeric 'a cure for Coronavirus'

From: mary ardley

Peter...about turmeric ...it is a good antibiotic, (and antiseptic and anti inflammatory and more ) but to my brief experience it cannot alone cure Corona Virus.

Quinine (in olive leaves) alone also does not cure it . but a combination of both actually does cure it... as I discovered not very long ago. This simple blend may be similar to what Didier Raoult discovered as a cure...

(33) Dr Brownstein's Holistic Medicine saves Jeremiah, at home (video). Need Nebulizer, Vit A,C,D, aqueous Iodine, food-grade Hydrogen Peroxide

https://www.drbrownstein.com/there-is-still-hope-out-there-iv:-it-hit-me-very-hard-and-fast.....i-had-to-lay-down.-i-was-exhausted./

There Is Still Hope Out There IV: It Hit Me Very Hard and FastÉ..I Had To Lay Down. I was Exhausted.

'It (fever) hit me very hard and fast last Saturday nightÉ..I had to go laydown. I was exhausted É..'

These are the words of my cousin and good friend, Jeremiah Freedman, who is a chiropractor in Ohio. Last weekend Jeremiah had shortness of breath, which is one of the symptoms of COVID19. He also had flu-like symptoms.

Watch my interview to learn how Jeremiah recovered by taking high doses of vitamin A, vitamin C, vitamin D & iodine and nebulization.

To All Our Health! ~DrB

Watch Jeremiah's testimonial on YouTube!

https://youtu.be/zk7Cr06Zi74

Brownstein advice: Vitamin A, C, D, aqueous Iodine; Nebulise food grade H2O2.

There Is Hope Out There lV:"It (fever) hit me very hard & fast..I had to lay down. I was exhausted."

31 Mar 2020

David Brownstein

These are the words of my cousin and good friend, Jeremiah Freedman, who is a chiropractor in Ohio. Last weekend Jeremiah had shortness of breath, which is one of the symptoms of COVID19. He also had flu-like symptoms. Watch my interview to learn how Jeremiah recovered by taking high doses of vitamin A, C, D & iodine, along with nebulizing.

Advice to Jeremiah:

Vitamin A 100,000 units a day

Vitamin D 50,000 units a day

continue Vitamin C

+ Iodine at least 50 ml {should be 50mg. See item 30 above, where he writes, "Penny-Lope, As my patient, I can give you medical advice. Take iodine along with it. At least 50 mg/day." He usually advises 1 or 2 drops of 5% aqueous Iodine in 200ml of saline solution}

+ Nebulise food grade Hydrogen Peroxide which is 35%; dilute it down to 3% (a 10 to 1 dilution). Mix that in a Saline solution: 1/4 teaspoon of unrefined salt (eg rock salt, Himalayan pink salt) in a cup of water. Let the particles fall down and skim off the top (200cc). Use that as our Nebuliser solution. Put 3cc of Saline and 3cc of Hydrogen Peroxide into the Nebuliser and start nebulising. {but see clarification of the mix in item 34 below}

"That nebuliser made a huge difference. It opened up my lungs. I did that twice yesterday. the first time I felt a little bit of burning in my throat as I did it., for a few minutes, and it caused me to cough a few times. ... I was able to walk around. About an hour later we did it again; we diluted it a little bit further and nebulised again, and took a hot bath, with salts - a salt bath. By evening my pulse had gone from 96-7 to 100.

Next morning, breathing was easier. I've done the nebulising three more times today. I feel like I can take a deep breath now. I'm still fatigued. I still don't feel back to normal, but I'm getting my energy back, and I feel I can breathe all the way in to my lungs, for the first time in days. That takes a lot of the fear away."

Dr B:

Conventional medicine has nothing to offer for this. If you go to hospital for this, they'll put you on a ventilator. Most people they put on a ventilator do not survive.

The above natural therapy can work, we've been doing this for 20+ years, this stuff does work

Jeremiah: My pulse has been better today, consistently 98, I'm breathing better, the panic has gone away, and my body is starting to heal. Previously, my lungs could not expand more than 50%, now I can take a full breath. After the nebulising, my cough went away.

Dr B: If Jeremiah had been closer, I would have had him come in, and would have given him intravenous (IV) Hydrogen Peroxide, an Ozone IV, and Vitamin C IV. These therapies work; we see them work in our practice. Find a holistic doctor.

(34) Dr Brownstein clarifies the Nebulizer mixture

- by Peter Myers, April 2, 2020.

Now Dr B. realises that, in telling people how to nebulize at home, he might be legally liable.

So he backtracks, advising to only do it under a doctor's supervision.

As if one can find Holistic Doctors at the drop of a hat!

Rather, they are rare like Hens' Teeth! And in a crisis like this, they will be already booked out.

But later, he tells how Jeremiah did the Nebulizing - and this is the way we can do it at home. ==

More About Nebulizing

https://www.drbrownstein.com/there-is-still-hope-out-there-v:-more-about-nebulizing

HomeDr B's blogDr B's Holistic Medicine Corona Virus

There Is Still Hope Out There V: More About Nebulizing

Apr 01 2020

Hi Folks,

WellÉpeople are reading and listening. I am hearing back from so many of you about nebulizing. Allow me to try and clarify how I do it in my practice. HOWEVER, nebulizers should only be used in conjunction with your doctor's advice. I am not directing anyone to nebulize anything on their own. Anything can be harmful, both natural items and synthetic drugs. Nebulizers should not be used without medical supervision.

I have many patients nebulize both hydrogen peroxide and iodine over the years. I have happily prescribed these therapies because they work and are safe when done appropriately.

Here's how my patients are instructed to nebulize hydrogen peroxide: My clinical staff mixes a bag of sterile normal saline, food grade-diluted hydrogen peroxide (food grade 35% diluted to 3%), and minerals. My partners and I have worked to perfect this formula for years. The patient draws off 3cc of the mixture and places it in a nebulizer and breathes the solution in. Sometimes I have them add a drop or two of 5% Lugol's iodine to the mixture. (Note: We only do this for active patients. If you are not an active patient, we will not send this to you. Mixing this solution makes it our responsibility. I take this responsibility to my patients seriously.) We charge $40.00 for this bag. There are about 80 treatments in the bag which comes out to $0.50 per treatment. This product is one of the best things we do in our practice. I have so many wonderful stories to tell about using this. Once mixed in the bag, since it is sterile, it can be used for a few months if kept in the refrigerator.

Iodine Nebulizing: I instruct my patients to add a drop or two of Lugol's 5% solution to 3 cc of normal saline (0.9% saline). Normal saline can be purchased at a pharmacy. If someone has Lugol's 2% solution, they can use 2-4 drops in 3cc of normal saline.

My patients are resourceful people. Sometimes they make their own nebulized solutions. I do not recommend these as they can have impurities and they will not store well. For example, some use over-the-counter 3% hydrogen peroxide (in the brown bottles and available at many stores). They take 3cc of that mixture and dilute it in 250cc of normal saline. Then they nebulize 3cc of that mixture. I have not heard of poor outcomes from doing this, but I would never recommend storing this solution as there are impurities in it.

In my cousin Jeremiah's case, we were in an acute situation. He was 200 miles away and could not breathe. We could not find normal saline, so I guided him to make his own saline solution. It is not as pure as buying sterile, normal saline. (Note: Do not buy normal saline with preservatives like eye saline solutions). Here's what I told Jeremiah's wife: Mix 1Ú4 tsp of Celtic Brand Sea Salt in a cup of clean water (distilled, reverse osmosis or something like that). Stir the solution up, let the particulate matter fall to the bottom. Scoop off the top until you have 250cc (or at least 200cc). 1 cup is equal to just over 200cc. Jeremiah used the 200 cc (or so) saline solution for the base.

His wife, Deanna, found 35% food grade hydrogen peroxide. Food grade peroxide is much cleaner than over-the-counter peroxide. To dilute 35% down to 3%, I had Deanna add 10cc of clean water to 1 cc of 35% hydrogen peroxide. That dilutes it down to 3% (very close to it). Once the 3% solution was made, I asked Deanna to take 3cc of that and mix it with the 200cc (or so) saline solution that she made up previously. Now he was ready to nebulize. I had Jeremiah take 3cc of the final mixture and nebulize it.

{above, he advises to add a drop or two of Lugol's 5% Iodine solution (any aqueous Iodine, for internal use) to 3 cc of the saline solution}

I would only use this mixture for a few nebulizing treatments until pure normal saline can be purchased. I would not store this solution for a long period of time.

I instruct my patients to nebulize 3-5 times per day if sick and 1-2 times per day if using it as a preventative.

I hope this helps. I cannot answer all the questions about nebulizing. We are doing telemedicine and taking new patients. We are happy to help you out with this. To make an appointment, call our Business Manager @ 248.851.1600 Ext 230.

Final Thoughts:

The internet sells a lot of bad products. I simply do not know what brand of food grade hydrogen peroxide sold on the internet to recommend. We use medical and professional sourcing for our intravenous and nebulized products. Therefore, it is best to work under the guidance of a competent holistic doctor who is skilled in IV therapy.

~DrB

(35) No Nebulizer? Try a bowl of boiling water & a towel over your head

https://www.drbrownstein.com/how-to-nebulize/

Margaret

01 Apr 2020

I read that if a person does not have a nebulizer that they could put boiling water in a bowl and add a dropper full of iodine in the boiling water and put a towel over their head and breathe in the steam. Would this work?

Reply David Brownstein, M.D. 01 Apr 2020

Margaret, I think there could be some benefit from that. I have not used that method. DrB

Comment (Peter M.): Unlike the flu, this virus attacks your lungs and stops you from breathing. If you get the virus, experience breathing difficulty, and choose to stay home, you could try to kill the virus in your lungs. You would use the kind of iodine for internal use, which is aqueous iodine (5%). Be cautious about dosage; add only one drop at a time to the bowl of water, and try it. Anyone who tries it, please let me know what you did, and the results.

That method might work with Hydrogen Peroxide too, but only at very low dosage, because too high a dose can cause harm; let me know kind, quantity and results. Use Dr Brownstein's advice as a guide. Unrefined salt (NaCl) is a catalyst, speeding up the decomposition of h2o2 into o2 (oxygen) and water (note that Dr B. uses a very weak saline solution): https://www.youtube.com/watch?v=VbqtUklgxzA .

Alternatively, you could try adding essential oils to the bowl of hot water, as discussed elsewhere in this webpage: Cinnamon, Rosemary, Lemon Balm, Fennel. Please let me know how you did it, the ingredients and quantities you added, and the results.

(36) Ways to inhale essential oils

From: Darren Cawley

Hi Peter,

You can get a small glass bottle put some cotton in the bottom and add a few drops of essential oil, you can sniff that like a smelling salts bottle.

Even better get a squeeze bottle and do the same and you can puff the air out whilst inhaling.

You can steam inhale essential oils, here is a link to a guide on how to do that

https://essentialoils.co.za/steam-inhalation.htm

Steam inhalation to help with upper respiratory tract and sinus problems.

Although the humble steam inhalation method cannot be seen as a cure for upper respiratory tract problems, nor a...

Steam inhalation with essential oil

When steam and essential oils are combined they form a very potent way to help treat some ailments, especially those of the upper respiratory tract, nose and sinuses. This type of treatment should not be used by anybody suffering from asthma.

Instructions to do steam inhalation steam inhalation essential oils

Pour hot water into a bowl and 3 drops of the essential oil that you have selected, place your head about 12 inches (30 cm) above the bowl and cover your head with a towel in such a way that the sides are totally closed and you in actual fact form a tent over the bowl.

Keep your eyes shut and breathe deeply through your nose for 1 to 2 minutes.

If you feel that the treatment is getting too much for you, raise the towel so that fresh air is brought into the area and breathe through your mouth a couple of times and then resume the treatment. Should you at any time feel uncomfortable discontinue the treatment.

When using this treatment with children or elderly people make sure that they do not burn themselves by getting too close to the bowl, or that the steaming water is upset and burns result.

(37) FDA permits CQ and HCQ to be used for Covid-19 (March 28) - vindicating Trump over Fauci

https://en.wikipedia.org/wiki/Hydroxychloroquine

On 28 March 2020, the (FDA) issued an emergency use authorization (EUA) to allow hydroxychloroquine

On 28 March 2020, the US Food and Drug Administration (FDA) issued an emergency use authorization (EUA) to allow hydroxychloroquine sulfate and chloroquine phosphate products donated to the Strategic National Stockpile (SNS) to be distributed and used for certain people who are hospitalized with COVID-19.[37][38]

https://www.npr.org/sections/coronavirus-live-updates/2020/03/30/823987540/fda-oks-addition-to-stockpile-of-malaria-drugs-for-covid-19

Malaria Drugs Get FDA 'Emergency Use Authorization' For COVID

Over the weekend, the Food and Drug Administration granted two malaria drugs "emergency use authorization" for the treatment of COVID-19. The move makes it easier to add the medicines to the strategic stockpile, which can be drawn upon in the current public health emergency.

The drugs - chloroquine and hydroxychloroquine - have been identified as potential COVID-19 treatments based on lab tests and small, limited studies in humans.

(38) Michigan reverses course on CQ & HCQ

https://www.foxnews.com/politics/michigan-reverses-course-on-trump-touted-coronavirus-drugs

Michigan reverses course on Trump-touted coronavirus drugs

By Brooke Singman | Fox News

Michigan Democratic Gov. Gretchen Whitmer's administration has requested an emergency supply of the drugs President Trump touted as having success treating patients with severe symptoms of the novel coronavirus, in a reversal from the state's directive to medical professionals last week to avoid the medication for this purpose.

Michigan, this week, requested hydroxychloroquine and chloroquine from the Strategic National Stockpile for physicians to use to help treat patients with COVID-19, after the Food and Drug Administration over the weekend granted an emergency use authorization for the anti-malarial drugs.

But last week, Whitmer's administration threatened physicians prescribing the drugs, saying they were subject to "administrative action" should they continue to use the medication.

"The Department of Licensing and Regulatory Affairs has received multiple allegations of Michigan physicians inappropriately prescribing hydroxychloroquine or chloroquine to themselves, family, friends, and/or coworkers without a legitimate medical purpose," Deb Gagliardi, the director of the Bureau of Professional Licensing, and Forrest Pasanski, the director of the Enforcement Division, wrote in a letter to "licensed prescribers and dispensers."

"Prescribing hydroxychloroquine or chloroquine without further proof of efficacy for treating COVID-19 or with the intent to stockpile the drug may create a shortage" for those patients who need the drug for its approved use, adding that "reports of this conduct will be evaluated and may be further investigated for administrative action.

"Again, these drugs have not been proven scientifically or medically to treat COVID-19."

"Michigan pharmacists may see an increased volume of prescriptions for hydroxychloroquine and chloroquine and should take special care to evaluate the prescriptions' legitimacy," they continued, warning again that "licensed health professionals are required to report inappropriate prescribing practices."

Michigan wasn't the only state last week to threaten physicians using the drugs- Nevada Gov. Steve Sisolak's administration also restricted the prescription of the medication, after a man died and his wife was hospitalized for using a fish tank cleaning additive with a similar name as a substitute.

"While the two drugs have necessary medical purposes, there is no conclusive evidence at this time among COVID-19 experts or Nevada's own medical health advisory team that the drugs provide treatment for COVID-19 patients," Sisolak said in a statement last week.

But Michigan reversed course, requesting a supply of the medications for physicians to use in treating patients of COIVD-19, after the Department of Health and Human Services received and accepted donations of the medications to the national stockpile to be used for coronavirus treatment.

(39) Ivermectin, anti-parasitic drug, kills COVID-19 in lab

https://www.news.com.au/lifestyle/health/health-problems/coronavirus-australia-ivermectin-antiparasitic-drug-kills-covid19-in-lab/news-story/615c435e56aefc4b704f4fd890bd4c2c

Ivermectin, Anti-parasitic drug kills COVID-19 in lab

A single dose of an anti-parasitic drug could essentially remove all genetic material of the COVID-19 virus within 48 hours, an Australian-led study has shown.

Christine McGinn, AAP

April 3, 202010:36pm

An anti-parasitic drug available throughout the world has been found to kill COVID-19 in the lab within 48 hours.

A Monash University-led study has shown a single dose of the drug Ivermectin could stop the SARS-CoV-2 virus growing in cell culture.

"We found that even a single dose could essentially remove all viral RNA (effectively removed all genetic material of the virus) by 48 hours and that even at 24 hours there was a really significant reduction in it," Monash Biomedicine Discovery Institute's Dr Kylie Wagstaff said on Friday.

While it's not known how Ivermectin works on the virus, the drug likely stops the virus dampening the host cells' ability to clear it.

The next step is for scientists to determine the correct human dosage, to make sure the level used in vitro is safe for humans.

The topical drug Ivermectin used to treat hookworm disease. Picture: The University of Sydney / Louise M CooperSource:Supplied

"In times when we're having a global pandemic and there isn't an approved treatment, if we had a compound that was already available around the world then that might help people sooner," Dr Wagstaff said.

"Realistically it's going to be a while before a vaccine is broadly available." Before Ivermectin can be used to combat coronavirus, funding is needed to get it to pre-clinical testing and clinical trials.

Ivermectin is an FDA-approved anti-parasitic drug also shown to be effective in vitro against viruses including HIV, dengue and influenza.

The study is the joint work of Monash Biomedicine Discovery Institute and the Peter Doherty Institute of Infection and Immunity.

The study findings have been published in Antiviral Research.

(40) ICU Dr: Ventilators should be set for Oxygen Deprivation, not Respiratory Failure

Cameron Kyle-Sidell is an emergency medicine physician in Brooklyn, New York, working every day with Covid-19 paterients.

In the video below he says that Patient symptoms are like High-Altitude Sickness (Oxygen Deprivation), not Viral Pneumonia.

Ventilators are wrongly being set to fix Respiratory Failure

They should be set to Oxygen Failure

https://hotcopper.com.au/threads/doctors-treating-the-wrong-disease.5328213/

Doctors treating the wrong disease? 1 Last Director12 14,107 Posts. 20 05/04/20 18:30

A NYC physician named Cameron Kyle-Sidell has posted two videos on YouTube, pleading for health practitioners to recognize that COVID-19 is not a pneumonia-like disease at all. It's an oxygen deprivation condition, and the use of ventilators may be doing more harm than good with some patients. The ventilators themselves, due to the high-pressure methods they are running, may be damaging the lungs and leading to widespread harm of patients.

Dr. Cameron Kyle-Sidell describes himself as an "ER and critical care doctor" for NYC. "In these nine days I have seen things I have never seen before," he says. Before publishing his video, we confirmed that Dr. Kyle-Sidell is an emergency medicine physician in Brooklyn and is affiliated with the Maimonides Medical Center located in Brooklyn.

In his video (see below), he goes on to warn the world that the entire approach to treating COVID-19 may be incorrect, and that the disease is something completely different from what the dogmatic medical establishment is claiming.

"In treating these patients, I have witnessed medical phenomena that just don't make sense in the context of treating a disease that is supposed to be a viral pneumonia," he explains.

He talks about how he opened a critical care using expecting to be treating patients with a viral pneumonia infection that would progress into Acute Respiratory Distress Syndrome (ARDS). But that the disease acted nothing like ARDS. "This is the paradigm that every hospital in the country is working under," he warns. "And yet, everything I've seen in the last nine days, all the things that just don't make sense, the patients I'm seeing in front of me, the lungs I'm trying to improve, have led me to believe that COVID-19 is not this disease, and that we are operating under a medical paradigm that is untrue."

More from Dr. Kyle-Sidell: (emphasis added)

In short, I believe we are treating the wrong disease, and I fear that this misguided treatment will lead to a tremendous amount of harm to a great number of people in a very short timeÉ I feel compelled to give this information out.

COVID-19 lung disease, as far as I can see, is not a pneumonia and should not be treated as one. Rather, it appears as if some kind of viral-induced disease most resembling high altitude sickness. Is it as if tens of thousands of my fellow New Yorkers are on a plane at 30,000 feet at the cabin pressure is slowly being let out. These patients are slowly being starved of oxygen.

And while [patients] absolutely look like patients on the brink of death, they do not look like patients dying from pneumoniaÉ I suspect that the patients I'm seeing in front of me, look as if a person was dropped off on the top of Mt. Everest without time to acclimate.

He goes on to explain that ventilators, in some cases, may be doing far more harm than good.

When we treat people with ARDS, we typically use ventilators to treat respiratory failure. But these patients' muscles work fine. I fear that if we are using a false paradigm to treat a new disease, then the method that we program [into] the ventilator, one based on respiratory failure as opposed to oxygen failure, that this method being widely adopted É aims to increase pressure on the lungs in order to open them up, is actually doing more harm than good, and that the pressure we are providing to lungs, we may be providing to lungs that cannot take it. And that the ARDS that we are seeing, may be nothing more than lung injury caused by the ventilator.

There are hundreds of thousands of lungs in this country at risk.

In other words, the real disease appears to cause oxygen deprivation in victims, not pneumonia. This is critically important for all the obvious reasons, and it raises huge questions about the origins of the coronavirus and whether there is some additional external factor beyond the virus that may be causing a combined effect that results in severe oxygen deprivation.

https://www.youtube.com/watch?v=1EWQPgF6-UQ&feature=youtu.be

(41) Another Dr. Brownstein video - Kendra's recovery

https://youtu.be/oAoLgDkv5Bc

https://www.drbrownstein.com/there-is-still-hope-out-there-vl:-i-just-felt-exhausted.-i-couldn't-move.-everything-hurt..../

There Is Still Hope Out There

Vl: I Just Felt Exhausted. I Couldn't Move. Everything HurtÉ.

Apr 05 2020

"É..I felt exhausted. I could not move. Everything hurtÉ..I could not even make it through a showerÉ.."

This an excerpt from Kendra's testimonial. She had flu-like symptoms for over a week including sore throat, runny rose, diarrhea, & fever. She also experienced a shortness of breath.

Kendra talks about the supplements and natural therapies that helped her recover from her illness. Watching this interview is a great way to end this week and provide us with the fortitude for the coming week. There is definitely hope out there!

To All Our Health!

~DrB

Click to hear Kendra's testimonial!

https://youtu.be/oAoLgDkv5Bc

(42) Main advantage of wearing a Mask (when out) is that it stops you from touching your face

https://youtu.be/YitWZj9QhdQ

This ICU doctor from NYC advises steps you should take to protect yourself:

Washing hands after touching objects out side your home; distancing; but also wearing a mask when you're out.

It does not need to be an N95 mask; any mask will do. The main advantage of wearing a mask is that it stops you from touching your face.

The advice part from from 09:30 to 15:30.

(43) COVID-19 starves your body of oxygen by binding to the heme groups in hemoglobin in your red blood cells

The original post, at medium.com, was deleted by that site.

https://www.sott.net/article/432300-Covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret

https://web.archive.org/web/20200405061401/https://medium.com/@agaiziunas/covid-19-had-us-all-fooled-but-now-we-might-have-finally-found-its-secret-91182386efcb

Covid-19 had us all fooled, but now we might have finally found its secret

libertymavenstock

Medium

Sun, 05 Apr 2020 18:54 UTC

In the last 3-5 days, a mountain of anecdotal evidence has come out of NYC, Italy, Spain, etc. about COVID-19 and characteristics of patients who get seriously ill. It's not only piling up but now leading to a general field-level consensus backed up by a few previously little-known studies that we've had it all wrong the whole time. Well, a few had some things eerily correct (cough Trump cough), especially with Hydroxychloroquine with Azithromicin, but we'll get to that in a minute.

There is no 'pneumonia' nor ARDS. At least not the ARDS with established treatment protocols and procedures we're familiar with. Ventilators are not only the wrong solution, but high pressure intubation can actually wind up causing more damage than without, not to mention complications from tracheal scarring and ulcers given the duration of intubation often required... They may still have a use in the immediate future for patients too far to bring back with this newfound knowledge, but moving forward a new treatment protocol needs to be established so we stop treating patients for the wrong disease.

The past 48 hours or so have seen a huge revelation: COVID-19 causes prolonged and progressive hypoxia (starving your body of oxygen) by binding to the heme groups in hemoglobin in your red blood cells. People are simply desaturating (losing o2 in their blood), and that's what eventually leads to organ failures that kill them, not any form of ARDS or pneumonia. All the damage to the lungs you see in CT scans are from the release of oxidative iron from the hemes, this overwhelms the natural defenses against pulmonary oxidative stress and causes that nice, always-bilateral ground glass opacity in the lungs. Patients returning for re-hospitalization days or weeks after recovery suffering from apparent delayed post-hypoxic leukoencephalopathy strengthen the notion COVID-19 patients are suffering from hypoxia despite no signs of respiratory 'tire out' or fatigue. Here's the breakdown of the whole process, including some ELI5-level cliff notes. Much has been simplified just to keep it digestible and layman-friendly.

Your red blood cells carry oxygen from your lungs to all your organs and the rest of your body. Red blood cells can do this thanks to hemoglobin, which is a protein consisting of four "hemes". Hemes have a special kind of iron ion, which is normally quite toxic in its free form, locked away in its center with a porphyrin acting as it's 'container'. In this way, the iron ion can be 'caged' and carried around safely by the hemoglobin, but used to bind to oxygen when it gets to your lungs.

When the red blood cell gets to the alveoli, or the little sacs in your lungs where all the gas exchange happens, that special little iron ion can flip between FE2+ and FE3+ states with electron exchange and bond to some oxygen, then it goes off on its little merry way to deliver o2 elsewhere.

Here's where COVID-19 comes in. Its glycoproteins bond to the heme, and in doing so that special and toxic oxidative iron ion is "disassociated" (released). It's basically let out of the cage and now freely roaming around on its own. This is bad for two reasons:

1) Without the iron ion, hemoglobin can no longer bind to oxygen. Once all the hemoglobin is impaired, the red blood cell is essentially turned into a Freightliner truck cab with no trailer and no ability to store its cargo.. it is useless and just running around with COVID-19 virus attached to its porphyrin. All these useless trucks running around not delivering oxygen is what starts to lead to desaturation, or watching the patient's spo2 levels drop. It is INCORRECT to assume traditional ARDS and in doing so, you're treating the WRONG DISEASE. Think of it a lot like carbon monoxide poisoning, in which CO is bound to the hemoglobin, making it unable to carry oxygen. In those cases, ventilators aren't treating the root cause; the patient's lungs aren't 'tiring out', they're pumping just fine. The red blood cells just can't carry o2, end of story. Only in this case, unlike CO poisoning in which eventually the CO can break off, the affected hemoglobin is permanently stripped of its ability to carry o2 because it has lost its iron ion. The body compensates for this lack of o2 carrying capacity and deliveries by having your kidneys release hormones like erythropoietin, which tell your bone marrow factories to ramp up production on new red blood cells with freshly made and fully functioning hemoglobin. This is the reason you find elevated hemoglobin and decreased blood oxygen saturation as one of the 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

2) That little iron ion, along with millions of its friends released from other hemes, are now floating through your blood freely. As I mentioned before, this type of iron ion is highly reactive and causes oxidative damage. It turns out that this happens to a limited extent naturally in our bodies and we have cleanup & defense mechanisms to keep the balance. The lungs, in particular, have 3 primary defenses to maintain "iron homeostasis", 2 of which are in the alveoli, those little sacs in your lungs we talked about earlier. The first of the two are little macrophages that roam around and scavenge up any free radicals like this oxidative iron. The second is a lining on the walls (called the epithelial surface) which has a thin layer of fluid packed with high levels of antioxidant molecules.. things like abscorbic acid (AKA Vitamin C) among others. Well, this is usually good enough for naturally occurring rogue iron ions but with COVID-19 running rampant your body is now basically like a progressive state letting out all the prisoners out of the prisons... it's just too much iron and it begins to overwhelm your lungs' countermeasures, and thus begins the process of pulmonary oxidative stress. This leads to damage and inflammation, which leads to all that nasty stuff and damage you see in CT scans of COVID-19 patient lungs. Ever noticed how it's always bilateral? (both lungs at the same time) Pneumonia rarely ever does that, but COVID-19 does... EVERY. SINGLE. TIME.

Once your body is now running out of control, with all your oxygen trucks running around without any freight, and tons of this toxic form of iron floating around in your bloodstream, other defenses kick in. While your lungs are busy with all this oxidative stress they can't handle, your organs are being starved of o2 without their constant stream of deliveries from red blood cell's hemoglobin, and your liver is attempting to do its best to remove the iron and store it in its 'iron vault'. Only its getting overwhelmed too. It's starved for oxygen and fighting a losing battle from all your hemoglobin letting its iron free, and starts crying out "help, I'm taking damage!" by releasing an enzyme called alanine aminotransferase (ALT). BOOM, there is your second of 3 primary indicators of whether the shit is about to hit the fan for a particular patient or not.

Eventually, if the patient's immune system doesn't fight off the virus in time before their blood oxygen saturation drops too low, ventilator or no ventilator, organs start shutting down. No fuel, no work. The only way to even try to keep them going is max oxygen, even a hyperbaric chamber if one is available on 100% oxygen at multiple atmospheres of pressure, just to give what's left of their functioning hemoglobin a chance to carry enough o2 to the organs and keep them alive. Yeah we don't have nearly enough of those chambers, so some fresh red blood cells with normal hemoglobin in the form of a transfusion will have to do.

The core point being, treating patients with the iron ions stripped from their hemoglobin (rendering it abnormally nonfunctional) with ventilator intubation is futile, unless you're just hoping the patient's immune system will work its magic in time. The root of the illness needs to be addressed.

Best case scenario? Treatment regimen early, before symptoms progress too far. Hydroxychloroquine (more on that in a minute, I promise) with Azithromicin has shown fantastic, albeit critics keep mentioning 'anecdotal' to describe the mountain, promise and I'll explain why it does so well next. But forget straight-up plasma with antibodies, that might work early but if the patient is too far gone they'll need more. They'll need all the blood: antibodies and red blood cells. No help in sending over a detachment of ammunition to a soldier already unconscious and bleeding out on the battlefield, you need to send that ammo along with some hemoglobin-stimulant-magic so that he can wake up and fire those shots at the enemy.

The story with Hydroxychloroquine

All that hilariously misguided and counterproductive criticism the media piled on chloroquine (purely for political reasons) as a viable treatment will now go down as the biggest Fake News blunder to rule them all. The media actively engaged their activism to fight 'bad orange man' at the cost of thousands of lives. Shame on them.

How does chloroquine work? Same way as it does for malaria. You see, malaria is this little parasite that enters the red blood cells and starts eating hemoglobin as its food source. The reason chloroquine works for malaria is the same reason it works for COVID-19 - while not fully understood, it is suspected to bind to DNA and interfere with the ability to work magic on hemoglobin. The same mechanism that stops malaria from getting its hands on hemoglobin and gobbling it up seems to do the same to COVID-19 (essentially little snippets of DNA in an envelope) from binding to it. On top of that, Hydroxychloroquine (an advanced descendant of regular old chloroquine) lowers the pH which can interfere with the replication of the virus. Again, while the full details are not known, the entire premise of this potentially 'game changing' treatment is to prevent hemoglobin from being interfered with, whether due to malaria or COVID-19.

No longer can the media and armchair pseudo-physicians sit in their little ivory towers, proclaiming "DUR so stoopid, malaria is bacteria, COVID-19 is virus, anti-bacteria drug no work on virus!". They never got the memo that a drug doesn't need to directly act on the pathogen to be effective. Sometimes it's enough just to stop it from doing what it does to hemoglobin, regardless of the means it uses to do so.

Anyway, enough of the rant. What's the end result here? First, the ventilator emergency needs to be re-examined. If you're putting a patient on a ventilator because they're going into a coma and need mechanical breathing to stay alive, okay we get it. Give 'em time for their immune systems to pull through. But if they're conscious, alert, compliant - keep them on O2. Max it if you have to. If you HAVE to inevitably ventilate, do it at low pressure but max O2. Don't tear up their lungs with max PEEP, you're doing more harm to the patient because you're treating the wrong disease.

Ideally, some form of treatment needs to happen to:

Inhibit viral growth and replication. Here plays CHQ+ZPAK+ZINC or other retroviral therapies being studies. Less virus, less hemoglobin losing its iron, less severity and damage.

Therapies used for anyone with abnormal hemoglobin or malfunctioning red blood cells. Blood transfusions. Whatever, I don't know the full breadth and scope because I'm not a physician. But think along those lines, and treat the real disease. If you're thinking about giving them plasma with antibodies, maybe if they're already in bad shape think again and give them BLOOD with ant ibodies, or at least blood followed by plasma with antibodies. Now that we know more about how this virus works and affects our bodies, a whole range of options should open up.

Don't trust China. China is ASSHOE. (disclaimer: not talking about the people, just talking about the regime). They covered this up and have caused all kinds of death and carnage, both literal and economic. The ripples of this pandemic will be felt for decades.

Fini.

(44) 85 COVID Patients at Dr Brownstein's Center for Holistic Medicine: Zero Hospitalizations and No Deaths

https://www.drbrownstein.com/85-chm-covid-patients:-zero-hospitalizations-and-no-deaths/

85 COVID Patients at The Center for Holistic Medicine: Zero Hospitalizations and No Deaths

Apr 09 2020

At my office, the Center for Holistic Medicine (CHM), we have had 85 COVID patients. At this time, no one has been hospitalized, no one has been diagnosed with pneumonia, and there have been no deaths.

There are five practitioners at CHM: Drs. Brownstein, Ng, Nusbaum, Jenny Drummond, PA, and Taylor Easson, NP. Since the start of the COVID-19 crisis, I have been asking my partners how their COVID patients are doing. As of this week, we have had 85 patients either diagnosed with COVID or suspected COVID. I am pleased to report that our patients are doing well with this illness. (Note, since new guidelines have come out stating that any suspected COVID patient can be diagnosed with COVID, I am lumping COVID and suspected COIVD patients together for this post.)

I first reported to you about COVID on January 26, 2020. That was the first time I presented our protocol of using vitamins A, C, D, and iodine not only to support the immune system but also to treat viral infections. In that post, I also pointed out how important eating a healthy diet is. The importance of using intravenous nutrient therapy, especially vitamin C, was mentioned. Finally, I suggested that, with coronavirus, it would be wise not to get a flu vaccine since the flu vaccine has been shown to significantly increase the risk of coronavirus and other flu-like viral infections.

That post seems like a lifetime ago even though it was only 10 weeks ago. During that time period, my message has not changed. In fact, after witnessing the results our patients have experienced, I am more convinced than ever that a holistic approach like I presented above should be the first-line treatment provided to any COVID patient.

The human body is a true wonder. Given the proper support, it can do wonders. And, when the body is healthy, it can withstand and overcome an infectious illness like COVID.

The initial conventional approach to COVID was to encourage people to wash their hands (a good thing). As things worsened, the only other conventional idea was to quarantine. When the disease spun out of control our Government and conventional medicine panicked. They had no real therapies to help COVID-suffering patients except for supportive care. Thankfully, a few conventional therapies, like hydroxychloroquine and azithromycin, have been promoted - though many in conventional medicine were downplaying it for far too long.

At my office, we were ready. The first 24 years of practicing holistic medicine was our time to figure out what worked and what did not work for people suffering from viral infections. That set us up to be ready for this pandemic.

In my blogs, I encouraged people to take high doses of vitamins A, C, D, and iodine at the first sign of an illness. In our practice, this was sufficient for the majority of our COVID patients. I (and my partners) have no doubt that the vast majority of COVID patients would avoid a deterioration of their symptoms if they started this protocol at the onset of symptoms.

However, some became more ill or did not start the oral supplements early enough into their illness. Those patients needed additional holistic therapies. These included nebulizing hydrogen peroxide and iodine along with intravenous nutrient therapies.

To protect our staff and healthy patients, we did not treat sick COVID patients inside my office. We were gowning up and meeting our patients at their automobile at the back of our building and administering IVs and ozone therapies. Some of these patients were very sick. So far, they all recovered. I have shared some of their stories via a skype interview on previous blog posts. To watch a few of our patient testimonials go to:

There Is Still Hope Out There (3/28/20): Christopher https://www.youtube.com/watch?v=YYiFuWa5ito

There Is Still Hope Out There (3/30/20): Jeremiah https://youtu.be/zk7Cr06Zi74

There Is Still Hope Out There (4/05/20): Kendra https://youtu.be/oAoLgDkv5Bc

{added April 24, 2020:
Apr 17 2020 - Andre: 'It was a remarkable recovery, going from a death bed to feeling almost 100%' https://youtu.be/Bo-xzvxGdhQ
Apr 18 2020 - Elizabeth: "Now that I am nebulizing properly I feel 95% better!" https://youtu.be/Mnx9-eTYe0s }

I think the end is in sight. We seem to be crossing over the hump of this dreadful disease. I have no doubt we will be in a much better position over the coming two weeks.

Folks, I hope the Powers-That-Be learn from this catastrophe. In the future, we need to focus on supporting the host rather than conventional medicine's focus on killing the infectious organism. We do not have a vaccine or any other conventional therapy that is successful at destroying COVID. In the future, I can guarantee you there will be other infectious illnesses that conventional medicine has no treatment to offer. Instead of waiting for the hail-Mary from conventional medicine, it is better to be prepared and have your body ready to fight back. This can be achieved by following my original instructions; eat a healthy diet, maintain optimal hydration, exercise, and correct nutrient imbalances with vitamin and mineral supplementation.

If you don't have a holistic doctor, it is past time to find one. At my office, we are happy to see you or do a telemed appointment. If you are interested in this please email Ann Salomon at info@centerforholisticmedicine.com.

A holistic doctor can help you achieve your optimal health. Conventional doctors, on the other hand, are busy diagnosing pathology and prescribing the drug to treat that diagnosis. The problem with the conventional model is that the drug prescribed does not promote health as nearly all drugs poison enzymes and block receptors in the body. There is a time and a place for drug therapies, but they are well over-prescribed in the US. The use of many drug therapies leaves the body depleted of vital nutrients that it will need when confronted with something like COVID.

As I previously stated, the Center for Holistic Medicine currently has 85 COVID patients who are all doing well and have not been hospitalized. There were some I was worried about - they kept me up at night. I called them daily to monitor their progress. Having them increase the frequency of nebulizing hydrogen peroxide and iodine helped them all. Some of the sickest were advised to nebulize every hour or two for a short period. IV therapies and ozone treatments have helped many.

This therapy has worked for helping COVID patients. It is sad that hospitalized COVID patients are not given the proper nutritional support when they are admitted. In a perfect world, I would immediately start an IV of vitamin C and begin nebulizing any hospitalized COVID patient with hydrogen peroxide and iodine. I am sure that would markedly lower the need for mechanical ventilation.

Final Thoughts:

Like most holistic therapies, the earlier they are started in a disease process the better they perform. AT THE FIRST SIGN OF A VIRAL ILLNESS I ENCOURAGE MY PATIENTS TO START MY VIRAL PROTOCOL OF TAKING VITAMINS A, C, D AND IODINE. Due to the severity of COVID, I now recommend starting to nebulize hydrogen peroxide and iodine early into the illness as well.

Better times are coming. Keep me updated on how you are doing. I will much more to talk about in relation to COVID. More posts will be coming soon.

To All Our Health,

~DrB

(45) Remdesivir & Chloroquine effectively inhibit Covid-19 vitro; authors include Zhengli Shi, director of P4 lab at Wuhan Institute of Virology

But Remdesivir is difficult to manufacture, and expensive; Chloroquine is cheap - Peter M.

authors: Zhengli Shi's team

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054408/

Cell Research

Nature Publishing Group

Cell Res. 2020 Mar; 30(3): 269­271.

Published online 2020 Feb 4. doi: 10.1038/s41422-020-0282-0

PMCID: PMC7054408

PMID: 32020029

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

Manli Wang,#1 Ruiyuan Cao,#2 Leike Zhang,#1 Xinglou Yang,#1 Jia Liu,1 Mingyue Xu,1 Zhengli Shi,1 Zhihong Hu,corresponding author1 Wu Zhong,corresponding author2 and Gengfu Xiaocorresponding author1

[...]

(46) New drugs EIDD-1931, EIDD-2801 for Covid-19

These new medicines are NOT vaccines. These new drugs were developed, in part, by Ralph Baric, whose lab in North Carolina did gain-of-function research in 2015, in which an ancestor of Covid-19 was bred. Note item 4 above, where Baric et al thank Zhengli-Li Shi of Wuhan Institute of Virology for bat CoV sequences and plasmid of WIV1-CoV spike protein. She participated in that 2015 research at the University of North Carolina. More details at http://mailstar.net/coronavirus.html - Peter M.

https://sph.unc.edu/sph-news/a-new-antiviral-drug-heading-into-clinical-trials-offers-hope-for-covid-19-treatment-in-part-because-it-can-be-taken-as-a-pill/

Ralph Baric, PhD, are working with colleagues in the lab of Mark Denison, MD, Edward Claiborne Stahlman Professor of pediatrics at Vanderbilt University Medical Center (VUMC), and with George Painter, PhD, chief executive officer of the nonprofit DRIVE (Drug Innovation Ventures at Emory) and director of the Emory Institute for Drug Development (EIDD), where EIDD-2801 was discovered.

The results of the team's most recent study were published online April 6 by the journal Science Translational Medicine. The paper includes data from cultured human lung cells infected with SARS-CoV-2, as well as mice infected with the related coronaviruses SARS-CoV and MERS-CoV.

The study found that, when used as a prophylactic, EIDD-2801 can prevent severe lung injury in infected mice. (EIDD-2801 is an orally available form of the antiviral compound EIDD-1931; it can be taken as a pill and can be properly absorbed to travel to the lungs.)

When given as a treatment 12 or 24 hours after infection has begun, EIDD-2801 can reduce the degree of lung damage and weight loss in mice. This window of opportunity is expected to be longer in humans, because the period between coronavirus disease onset and death is generally extended in humans compared to mice.

"This new drug not only has high potential for treating COVID-19 patients, but also appears effective for the treatment of other serious coronavirus infections," said senior author Baric.

Compared with other potential COVID-19 treatments that must be administered intravenously, EIDD-2801 can be delivered by mouth as a pill. In addition to ease of treatment, this offers a potential advantage for treating less-ill patients or for prophylaxis - for example, in a nursing home where many people have been exposed but are not yet sick.

"We are amazed at the ability of EIDD-1931 and -2801 to inhibit all tested coronaviruses and the potential for oral treatment of COVID-19. This work shows the importance of ongoing National Institutes of Health (NIH) support for collaborative research to develop antivirals for all pandemic viruses, not just coronaviruses" said Andrea Pruijssers, PhD, the lead antiviral scientist in the Denison Lab at VUMC.

Denison was senior author of a December 2019 study that first reported that EIDD-1931 blocked the replication of a broad spectrum of coronaviruses.

These interinstitutional collaborators, supported by an NIH grant through the University of Alabama at Birmingham, also performed the preclinical development of remdesivir, another antiviral drug currently in clinical trials of patients with COVID-19. In the new Science Translational Medicine paper, Maria Agostini, PhD, a postdoctoral fellow in the Denison lab, demonstrated that viruses that show resistance to remdesivir experience higher inhibition from EIDD-1931.

"Viruses that carry remdesivir resistance mutations are actually more susceptible to EIDD-1931 and vice versa, suggesting that the two drugs could be combined for greater efficacy and to prevent the emergence of resistance," said Painter.

Clinical studies of EIDD-2801 in humans are expected to begin later this spring. If they are successful, the drug could not only be used to limit the spread of SARS-CoV-2, but also could control future outbreaks of other emerging coronaviruses.

"With three novel human coronaviruses emerging in the past 20 years, it is likely that we will continue to see more," said first author Timothy Sheahan, PhD, a Gillings assistant professor of epidemiology and a collaborator in the Baric Lab. "EIDD-2801 holds promise to not only treat COVID-19 patients today, but to treat new coronaviruses that may emerge in the future."

Contact the Gillings School of Global Public Health communications team at sphcomm@unc.edu. ==

EIDD-2801 could become the first pill for COVID-19 - Scientific American

https://www.scientificamerican.com/article/new-coronavirus-drug-shows-promise-in-animal-tests1/

New Coronavirus Drug Shows Promise in Animal Tests

Slated for human trials, EIDD-2801 could become the first pill for COVID-19

By Michael Waldholz

Scientific American April 7, 2020 [...]

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