Cuba is 99% vaccinated but very little Autism - incidence in US is 298 times higher than in Cuba

- Peter Myers

Date March 17, 2020

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Cuba is 99% vaccinated but has a very low rate of Autism. William Shaw wrote that the incidence in the US is 298 times higher than in Cuba. Shaw, who had worked for 6 years at the CDC, blamed acetaminophen (Tylenon, Panadol), a pain-killer commonly given just before or after vaccination to reduce fever and pain.

The vaccines used in Cuba must be different from those used in the West. Perhaps the difference lies in preservatives (eg mercury) added to Western vaccines; or in the combination of vaccines given in the West; or in medications given in conjunction with the vaccine, as Shaw argued.

Ivan Illich called the harm done by the Medical Profession 'Iatrogenesis', in his book Medical Nemesis. He noted that doctors are businessmen - quite possibly putting THEIR interest before yours. But they are not all the same; when you find a good one, treasure that person.

(1) Autism rate rose sharply as Acetaminophen (Tylenon, Panadol) was substituted for children's Aspirin
(2) Some pediatricians routinely use Acetaminophen to prevent vaccine-related fever
(3) Cuba has the most extensive vaccination program in the world
(4) Five Compelling Reasons to Ditch the Tylenol (Panadol) with Vaccines
(5) Parent survey: Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder
(6) Tylenol: A Major Culprit in the Autism, ADHD, and Asthma Epidemic
(7) Tylenol/Panadol use at vaccination causes Autism in genetically vulnerable children - William Shaw (2015)
(8) Explosion of Autism in China after adoption of WHO-recommended infant vaccination programs - F. William Engdahl
(9) Dr. Andrew Wakefield, vaccine whistelblower, exonerated of charges that he conducted fraudulent tests
(10) Economist: More evidence that Autism is linked to Gut Bacteria
(11) CBC documentary about Autism: The Autism Enigma, presented by David Suzuki
(12) CBC documentary shows Autism caused by harmful Bacteria in the gut

(1) Autism rate rose sharply as Acetaminophen (Tylenon, Panadol) was substituted for children's Aspirin

https://www.wvgazettemail.com/opinion/hanno-kirk-new-link-to-autism-epidemic/article_13dc838b-3f21-57b4-94e5-1d09faf7fb6d.html

Hanno Kirk: New link to autism epidemic

Apr 16, 2012

CHARLESTON, W.Va. -- Autism is reaching epidemic levels in the United States. Many theories have been proposed.

For a while thimerosal, the mercury based preservative used in vaccines was suspected. Many parents, not wishing to put their infant children at risk, have refused to have their children vaccinated.

Now comes the news that the culprit is not the vaccines, or even the mercury based preservative. (In 2007 the FDA prohibited the use of thimerosal in childhood vaccines). Instead, convincing evidence from multiple studies now points to the action of acetaminophen.

Since 1978, acetaminophen has routinely been given by American pediatricians with vaccinations to prevent fever and pain. That was the year a study was published linking aspirin to Reyes syndrome. (Subsequent studies have shown no linkage between aspirin and Reyes).

A study from California shows how the autism rate rose sharply as acetaminophen was substituted for children's aspirin. Enter William Shaw Ph. D. , Director of the Great Plains Laboratories, who had been wrestling with the problem of the causes of autism for many years. His breakthrough Aha! came when he looked at the autism rates in Cuba.

That island nation with a population of 11 million has only 185 cases of autism for a rate of 0. 00168 percent. By comparison the Center for Disease Control on March 30 published data that shows the prevalence of autism in children up to age 8 to be 1 in 88 for a rate of 1. 13 percent. This was a 23 percent increase over the previous survey in 2006.

The Cuban vaccination rate is 99 percent, and by age 6 each child has received 34 shots. By comparison vaccination rates in the United States for most shots are in the 85 percent range.

The major difference is that in Cuba acetaminophen is available only by prescription, and is never given with vaccinations. Indeed the attitude of the Cuban medical establishment is that fever is a normal and beneficial side effect of vaccinations. It is seen as proof that the body's immune system is responding appropriately to the challenge of the vaccination. Their rule is not to give medication unless the fever is above 104F or lasts longer than two days.

The stark differences in rates of autism between the two nations led Shaw to conclude that it was not the vaccinations, but rather the acetaminophen that was the culprit for the sharp rise in autism in nations that routinely use products like Tylenol for children.

Dr. Shaw came upon lots of evidence that when acetaminophen breaks down in the body it produces several toxic metabolites. One important player in this drama is an enzyme known as Cytochrome p450 2E1. This enzyme breaks down the acetaminophen into a highly toxic metabolite NAPQI. This metabolite attacks glutathione, which is the mainstay of the body's immune system.

So, after a vaccination, when the body most needs to mobilize the immune system to build antibodies, glutathione, the principal protein supporting it, is being destroyed by the NAPQI.

This is why so many of the children in the autism spectrum have a wide variety of highly sensitive or weakened immune systems (allergies, intestinal problems).

Part of the problem is that the concentration of acetaminophen in infant Tylenol liquid is high enough to produce toxic reactions, including possible liver damage with repeated doses over several days.

One other key piece of evidence came from cases where acetaminophen was given starting five days before the vaccination. In a significant number of children, autistic regression started before the vaccination was given.

One of the main uses of acetaminophen is for reducing pain. It does so by engaging the cannabanoid receptors in the brain (the same ones that produce a feeling of well being after marijuana use). This is what produces the analgesic effect. This is where it gets complicated. The analgesic effect is produced by the breakdown of acetaminophen, but some children process acetaminophen differently from others.

The process helps to eliminate acetaminophen from the body. An impaired process means that even "safe" doses can produce to an overdose effect. Too much acetaminophen not only affects the immune system, but also impairs brain development.

In children who are diagnosed within the autism spectrum, this developmental interference appears to be concentrated in several regions of the brain. One key area is the neural networks which process social and emotional information. The networks that modulate inhibition also appear affected. In some cases the development of speech is diminished. Unfortunately much of this information is not yet widely known.

Acetaminophen is still one of the most widely used analgesics and fever reducers.

Kirk is a licensed independent clinical social worker in Lewisburg.

(2) Some pediatricians routinely use Acetaminophen to prevent vaccine-related fever

https://www.webmd.com/children/vaccines/news/20091015/tylenol-may-weaken-infant-vaccines

Tylenol May Weaken Infant Vaccines

Acetaminophen Linked to Poorer Immune Response to Infant Vaccines

By Daniel J. DeNoon

FROM THE WEBMD ARCHIVES

Oct. 15, 2009 - Acetaminophen, the active ingredient in Tylenol, weakens infants' immune responses to vaccines, a compelling new study suggests.

Infants often get a mild fever after getting vaccines. Some pediatricians routinely use acetaminophen to prevent vaccine-related fever.

But that's not a good idea, finds an international research team led by Roman Prymula, MD, of the University of Defense, Czech Republic.

In a study looking at whether acetaminophen really prevents vaccine-related fever, Prymula and colleagues found that the common over-the-counter pain remedy dampens vaccine-induced immune responses.

It's not yet clear whether other fever-reducing drugs, such as ibuprofen, have the same effect. But the researchers warn doctors and parents to try to avoid using acetaminophen, ibuprofen, or other fever-reducing drugs to prevent vaccine-related fever. And of course, aspirin should never be given to a child with fever.

It's good advice, says Robert T. Chen, MD, chief of vaccine safety for the CDC's National Immunization Program.

"A fever is likely a critical part of the immune response to any infection or vaccination, so dampening fever after immunization is probably not a good idea for most kids," Chen tells WebMD.

If preventing fever with acetaminophen is a bad idea, what should a parent do if a child develops a fever after vaccination?

"The issue is not whether the child has a temperature, but whether the child is sick," Chen says. "So after immunization, if the child is fine and happy, don't worry. But if the child is fussy and looks sickly, consult your doctor to see whether you should give acetaminophen."

The Prymula study supports this advice. Even infants who were not given acetaminophen rarely had a fever above 103 F.

However, the Prymula study did not look at other fever-reducing drugs -- ibuprofen in particular....

The Prymula study and an editorial by Chen and colleagues appear in the Oct. 17 issue of The Lancet.

(3) Cuba has the most extensive vaccination program in the world

https://www.workers.org/2020/03/46641/

By a guest author posted on March 4, 2020

By Rosa Miriam Elizalde

Rosa Miriam Elizalde is a Cuban journalist and editor of the site Cubadebate. Reprinted from La Jornada, translation by Resumen Latinoamericano, North America bureau.

[...] Cuba has the most extensive vaccination program in the world (recognized by the Pan American Health Organization and other international organizations), which includes universal coverage for newborns with vaccines against 13 diseases; epidemiological surveillance with the use of immunoassays for more than 20 diseases; hospitals regularly use medicines such as interferon, monoclonal antibodies, cytokines, and other biopharmaceuticals. ...

(4) Five Compelling Reasons to Ditch the Tylenol (Panadol) with Vaccines

https://www.kitchenstewardship.com/risks-Tylenol-with-vaccines/

5 Compelling Reasons to Ditch the Tylenol with Vaccines

by Katie Kimball @Kitchen Stewardship

February 19, 2016 (UPDATED: August 17, 2019)

Pain Relief and Vaccines a Dangerous Mix

Nobody wants to see their child in pain, especially wee little infants.

So, I've done it.

When my oldest was under a year old, I gave him Tylenol after he spiked a fever a few hours after a round of vaccinations. I wasn't a huge fan of medications even before I was a very crunchy mama, so it was a compromise even then. And now?

The evidence against mixing acetaminophen and vaccines is so overwhelming, I couldn't dream of it. The risk is too great and reward almost non-existent.

I've had such fascinating conversations with Catherine Clinton, ND, founder of WellFuture(today's sponsor), and one pattern is always consistent: She wants to get information out there into the hands of parents who need it. She's a passionate researcher and educator, and I always come away with something new to chew on.

Most recently, we talked about Tylenol and vaccines. It's actually old news in a way, with rumblings of problems starting as early as some 2008 research, but for whatever reason it's just barely creeping into mainstream knowledge now. Our pediatrician told us about it only last year.

This is the part of the show where Katie reminds everyone that she's "just a mom" and has a teaching and English degree, not a medical degree of any kind. I just report on what I've read, and this is not to be taken as medical advice of any kind. Just a conversation. Information. Talk to your own trusted, certified doctor before making medical decisions.

Why Tylenol (Acetaminophen) Should Never be Used for Vaccine Preparation

Some of the studies cited here were done with Tylenol post-vaccines and others before, but they all come down on the side of NO mixing. Here's what researchers found:

1. Acetaminophen (or likely any fever reducer) actually interferes with the effectiveness of the vaccine itself! A vaccination is not a magic shot that protects from disease like a shield of armor. The body needs to respond by mounting a defense to the disease, and to do that, its own immune system must be functioning well.

Because Tylenol is likely to reduce fever, researched here as, I assume, a positive benefit, it actually prevents the body from doing its job as effectively as it should to create protection from the disease. This has been studied in children in 2009 and also young adults in 2014.

2. Tylenol also serves to deplete glutathione levels in the body, which are responsible for detoxification. When little bodies need their systems to be in tip top shape to process the ingredients in the vaccine itself, acetaminophen makes that more difficult.

3. Tylenol use after vaccinations is correlated with 8x the rate of autism as compared to ibuprofen. Correlation is not necessarily causation, but evidence is mounting. (A study in 2008 demonstrated a link, and Dr. William Shaw of the Great Plains Laboratory has been researching a possible link between acetaminophen and autism in general, with a published paper in the Journal of Restorative Medicine in October 2013.)

4. Tylenol has also been linked generally (outside of vaccination time) to autism and asthma, in 2005 and 2010.

5. And Tylenol has plenty of ingredients that we don't normally give our kids ­ Erin of the Humbled Homemaker wrote a great guest post a few years ago at KS on what's really in children's medications.

Again, this isn't new news ­ but it's important!

The bottom line, from Dr. Catherine: Make sure your doctor does not routinely give Tylenol or acetaminophen with childhood shots. Consider ibuprofen only after vaccination to help with the more severe vaccine side effects in your child. While fevers are a common side effect from vaccines and can be uncomfortable for children, it is best to let the fever run its course, rather than trying to suppress with acetaminophen or ibuprofen. Remember the increased temperature is essential for the body to mount the white blood cell defenses against the infection, or vaccine antigen in this case.

(5) Parent survey: Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder

https://www.ncbi.nlm.nih.gov/pubmed/18445737

Autism. 2008 May;12(3):293-307. doi: 10.1177/1362361307089518.

Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: the results of a parent survey.

Schultz ST1, Klonoff-Cohen HS, Wingard DL, Akshoomoff NA, Macera CA, Ji M.

Author information

Abstract

The present study was performed to determine whether acetaminophen (paracetamol) use after the measles-mumps-rubella vaccination could be associated with autistic disorder.

This case-control study used the results of an online parental survey conducted from 16 July 2005 to 30 January 2006, consisting of 83 children with autistic disorder and 80 control children. Acetaminophen use after measles-mumps-rubella vaccination was significantly associated with autistic disorder when considering children 5 years of age or less (OR 6.11, 95% CI 1.42-26.3), after limiting cases to children with regression in development (OR 3.97, 95% CI 1.11-14.3), and when considering only children who had post-vaccination sequelae (OR 8.23, 95% CI 1.56-43.3), adjusting for age, gender, mother's ethnicity, and the presence of illness concurrent with measles-mumps-rubella vaccination. Ibuprofen use after measles-mumps-rubella vaccination was not associated with autistic disorder.

This preliminary study found that acetaminophen use after measles-mumps-rubella vaccination was associated with autistic disorder.

A response to the article on the association between paracetamol/acetaminophen: use and autism by Stephen T. Schultz. [Autism. 2009]

PMID: 18445737 DOI: 10.1177/1362361307089518

(6) Tylenol: A Major Culprit in the Autism, ADHD, and Asthma Epidemic

https://latitudes.org/Tylenol-major-culprit-autism-asthma-epidemic/

December 15, 2013/

by ACN Report

A recent journal article by William Shaw, PhD (left) details his claim that use of acetaminophen (Tylenol) is behind the dramatic increase in autism, asthma, and ADHD in the world. A researcher and director of The Great Plains Laboratory, Dr. Shaw is so convinced of the dangers of Tylenol that he has issued "A Call to Action" to stop its use in children under the age of three, and to increase public awareness of its potential for significant negative side-effects.

The incidence of autism in the USA is now 1 in 50. The dramatic rise over recent decades is not due to "better diagnosis," as some like to suggest. A search for environmental causes has yielded a range of possibilities, but no single factor explains the depth of the crisis. In his latest research paper, Dr. Shaw, an advisory board member for ACN Latitudes, presents compelling data that points to the use of acetaminophen by pregnant mothers and susceptible young children as a key causative factor.

Shaw's article, "Evidence that Increased Acetaminophen use in Genetically Vulnerable Children Appears to be a Major Cause of the Epidemics of Autism, Attention Deficit with Hyperactivity, and Asthma," is published in the Journal of Restorative Medicine (October 2013).

Those with the scientific background to tackle the chemistry behind Dr. Shaw's hypothesis will find his explanations detailed and fascinating. Others will be able to skip article sections that are too technical and still grasp his urgent message. ...

(7) Tylenol/Panadol use at vaccination causes Autism in genetically vulnerable children - William Shaw (2015)

Evidence That Increased Acetaminophen Use In Genetically Vulnerable Children Appears To Be A Major Cause Of The Epidemics Of Autism, Attention Deficit With Hyperactivity, And Asthma

November 16, 2015 Mental Disorders

William Shaw, Ph.D.

https://www.greatplainslaboratory.com/articles-1/2015/11/13/evidence-that-increased-acetaminophen-use-in-genetically-vulnerable-children-appears-to-be-a-major-cause-of-the-epidemics-of-autism-attention-deficit-with-hyperactivity-and-asthma

Introduction

One of the puzzling aspects of autism is the marked increase in the incidence of autism that began in the United States in the early 1980s and has appeared to increase continuously since then. The highest incidence of autism has been reported to be South Korea, where the incidence is now reported to be one in 38 boys. [1]Increased incidence of autism due to more effective diagnosis was disproved in the study of Irva Hertz-Picciotto who showed that perhaps 12% of the increased autism diagnoses could be attributed to improved diagnosis [2]. A wide range of environmental factors has been associated with increased autism incidence, including pesticides, chemicals, phthalates, polychlorinated biphenyls, solvents, heavy metals or other pollutants. [3]Although toxic chemicals are undoubtedly not beneficial for the health of any person, is there any information that indicates that a toxic avalanche of chemicals inundated the United States in the early 1980s? Indeed a wealth of knowledge about environmental chemicals has led to marked reductions in exposure to chemicals such as lead and dichlorodiphenyltrichloroethane (DDT) in the United States over the past 50 years. For example, acceptable safe limits for levels of lead in the blood have decreased from 60 mg/dL in 1960 to <5 mg/dL in 2010 [4].

Making a connection between disease appearance and causative agent is important. Clinical studies, epidemiological studies and post-market pharmacovigilence are of utmost importance in recognizing signals and drug-induced side effects. One of the most notable cases of serious adverse effects caused by a pharmaceutical agent was the terrible developmental epidemic of the birth of children with seal-like arms and legs (phocomelia) that was linked to the maternal use of the sedative thalidomide 20­35 days after conception [5]. What would have happened if the thalidomide connection had never been made? One of the difficulties with chemical studies of autism associations is that most chemicals are used worldwide, making it difficult to find a "clean" environment where autism might be less prevalent. One of the clues that led to the discovery of thalidomide as the causative agent of deformed limbs was that it was much more commonly used in Europe than in the United States. Countries with the greatest use of thalidomide by pregnant women during pregnancy were those with the highest incidence of deformed babies. If there was a geographic region in the world in which the incidence of autism was much lower than that in the United States, a comparison of medical or dietary differences might provide a significant clue to the major cause of autism.

Such a country is Cuba. The highest estimate of the total incidence of autism in Cuba is 185 cases out of a total population of 11,000,000 (0.00168% of the population) compared with an estimate of as high as 1.5 million in a total United States population of 300 million (0.50%) [6, 7]. The percentage of the population with autism in the United States is thus 298 times higher than in Cuba. Cuba is much more economically challenged than the United States, with the per capita income of Cuba approximately eight times lower than that in the United States. Despite the economic challenges presented to the communist government of Cuba, basic healthcare is readily available and there are a large number of physicians trained in 14 different medical schools. Unlike the United States, where vaccines are optional in many states, vaccines are compulsory in Cuba and Cuba has one of the most highly vaccinated populations in the world against a wide variety of infectious agents.[8] For example, the vaccination rate for measles was reported to be 99.7%. The association of autism with various vaccines has had a very controversial history with inflamed passions on both sides of the debate and will not be examined here.

However, a topic much less frequently addressed in association with autism is the therapies that are given in conjunction with vaccines.

The practice of prescribing acetaminophen as a prophylactic fever preventative is widespread in the United States but is very uncommon in Cuba (personal communications, Dr Olympio Rodriquez Santos MD, MSc, Allergist, Camaguey, Cuba). In the United States, some physicians have started to advise parents to begin to take acetaminophen prophylactically daily 5 days prior to childhood vaccines; some children on such prophylactic treatment had an autistic regression that began prior to vaccination (personal communication, Kerry Scott Lane MD, Anesthesiologist, West Palm Beach, Florida, USA). In Cuba, acetaminophen is not approved as an over-the-counter (OTC) product, however, it has been available as an OTC product since 1959 in the United States. Furthermore, in Cuba, prophylactic use of antipyretic drugs is not the standard medical treatment for vaccine-related fever (personal communications with Dr Olympio Rodriquez Santos). If high fever continues after vaccination in Cuba for more than 2 days, the parents are advised to visit the physician's office where the drug metamizole is most commonly prescribed. Prescription of acetaminophen in such cases is rare. Metamizole is used in many countries throughout the world but is banned in the United States and some other countries because of a rare association with agranulocytosis.[9]

Could the Use of Certain Antipyretic Drugs, Especially in Conjunction with Vaccines, be a Cause of Autism?

Torres was the first to ask if the suppression of fever by antipyretic drugs commonly used at the time of vaccination might cause the severe immune abnormalities that are prevalent in autism.[10] Schultz et al. were even more specific when indicating in a series of articles that biochemical and immune disorders caused by increased use of the common drug acetaminophen may have caused the autism epidemic (Figure 1).[11­14]

Acetaminophen is also termed paracetamol and N-acetyl-p-aminophenol (AAP or APAP). More than 70% of the population in western countries has taken acetaminophen at least once, and a relevant percentage takes the drug chronically as a mild pain reliever and antipyretic.[15]

Acetaminophen is used to treat pain and fever and it has become one of the most popular OTC non-narcotic analgesic agents. For example, this compound has been taken at least once by >85% of children under the age of 91 months in the UK.15 In the US, approximately 79% of the general population regularly takes acetaminophen, including more than 35% of pregnant women.[15]Acetaminophen has grown in popularity in large part due to its reputation for safety. For generations, Tylenol® (a popular brand of acetaminophen) advertisements have painted it as "the pain reliever hospitals use most." Acetaminophen is in >600 OTC and prescription products, from headache and cold remedies to cough syrups and sleep aids.[16]

The study by Schultz et al. was the first to specifically link increased acetaminophen use to increased autism.[11]This study included a graph similar to Figure 1 temporally relating increased autism incidence in California with increased acetaminophen use in the United States and decreased acetaminophen use with decreased rate of autism in California. In addition, similar increases in the rates of asthma correlated with the usage of acetaminophen were also noted by Becker and Schultz.[14]

They noted that the rates of autism incidence and asthma stopped increasing in the months following two attempted extortion events in which acetaminophen was deliberately laced with cyanide.[14] The changes in the incidence of these very different diseases at exactly the time acetaminophen use dropped for a significant period of time is remarkable and may indicate the same factor as causing the two diseases. In addition, the autism paper by Schultz et al. included the results of an online survey of parents who had given their child the combined measles, mumps, rubella (MMR) vaccine, which revealed that children with autism had more adverse reactions to the MMR vaccine and were more likely to have been given acetaminophen than ibuprofen for those reactions.[11]

Compared with controls, children aged 1­5 years with autism were eight times more likely to have become unwell after the MMR vaccine, and were six times more likely to have taken acetaminophen. Children with autism who regressed in development were four times more likely to have taken acetaminophen after the vaccine. Illnesses concurrent with the MMR vaccine were nine times more likely in autistic children when all cases were considered, and 17 times more likely after limiting cases to children who regressed. There was no increased incidence of autism associated with ibuprofen use.

The incidence of attention deficit with hyperactivity over the last 50 years follows patterns similar to those of autism and asthma, although the data for attention deficit-hyperactivity disorder (ADHD) are not available to the same depth as the data for autism and asthma. Before 1970, the diagnosis of ADHD was relatively rare for schoolchildren and almost nonexistent for adolescents and adults. Between 1980 and 2007, there was an almost 8-fold increase of ADHD prevalence in the United States compared with rates of 40 years ago.[25]Prevalence of ADHD in American schoolchildren was 1% in the 1970s, 3­5% in the 1980s, and 4­5% in the mid-to-late 1990s.[18­24] A study of hospital discharge rates for ADHD between 1989 and 2000 found a 381% increase over the study period.[25]

Use of acetaminophen dramatically increased in the United States in the 1980s due to a concern over an association of aspirin with Reye's syndrome, although a number of critics reject this hypothesis.[26­28]

For example, the current recommendations for the management of children with Kawasaki disease include treatment with high-dose aspirin in the acute phase, and low-dose aspirin during the period of thrombocytosis. For those with residual coronary problems, low-dose aspirin is often given over an even longer term. In Japan alone, up to 200,000 children have received aspirin for Kawasaki disease. Interestingly, only one case of Reye's syndrome associated with Kawasaki disease has ever been reported, and only in the Japanese literature, giving an incidence of 0.005%.[26] In addition, retrospective reevaluation of patients with a diagnosis of Reye's syndrome who survived has revealed that many, if not most, had an underlying inborn error of metabolism (IEM).[28] Many of these IEMs had not even been described when the diagnosis of Reye's syndrome was made. Inborn errors that may mimic Reye's syndrome include fatty-acid oxidation defects, amino and organic acidopathies, urea-cycle defects, and disorders of carbohydrate metabolism.[28] Future discovery of other IEMs may ultimately explain even more of these cases. Additional etiologies that may mimic Reye's syndrome include viral infections, neuromuscular diseases, adverse drug reactions, and exposure to toxic chemicals and plants that cause hepatocellular damage and encephalopathy.[28] Diagnostic methods such as GC/MS became more widely available in the 1980s and later so that the patients with IEMs were diagnosed with an IEM instead of Reye's syndrome. The main cause of Reye's syndrome appears to be the accumulation of nonesterified fatty acids and lysolecithins that have a high detergent activity and thus denature all proteins.[29]

It is interesting that Cuba, which has a lower autism rate than the United States, allows the use of acetaminophen only by prescription, therefore, the use of acetaminophen in Cuba is only a minuscule fraction of acetaminophen use in the United States and many other countries throughout the world. When acetaminophen use was limited by a prescription requirement in the United States, the rate of autism was a small fraction of current rates of autism.

Unlike thalidomide, which was once promoted for its extreme safety prior to the discovery of its teratogenicity, acetaminophen has a long history of serious side effects associated with its use (Table 1).[47]

Table 1 (Click for larger view) Table 1 (Click for larger view)

Acetaminophen produces neurotoxic effects on rat brain neurons both in vitro and in vivo, its use during pregnancy is associated with teratogenic defects in testicular function and the gastrointestinal tract, and there is increased incidence of asthma in maternally exposed and postnatally exposed children.[13­15, 30, 31, 44-46]Acetominophen is converted to the very toxic metabolite N-acetyl-pbenzoquinone imine (NAPQI; Figure 2), which can cause oxidative damage to proteins, nucleic acids, amino acids, and lipids, in addition to increased mitochondrial and cellular damage and death.[32­35]

Acetaminophen also causes severe immune abnormalities at doses that do not damage the liver, depresses the immune response to vaccination, can cause severe metabolic acidosis when glutathione (GSH) is depleted, is the leading cause of liver failure and death in the United States, is associated with increased rates of certain blood cancers, and results in tens of thousands of visits to the emergency room and hospitalizations in the United States.[14, 36­43] A PubMed search of the scientific literature indicated the presence of 2685 articles regarding acetaminophen toxicity.

An article with the title, "Did acetaminophen cause the autism epidemic?" was more pointed.[48] The rest of this article will deal with the known toxicity of acetaminophen and how other known anatomical, immunologic, biochemical, and infectious aspects of autism can be related to the effects of acetaminophen. ...

(8) Explosion of Autism in China after adoption of WHO-recommended infant vaccination programs - F. William Engdahl

"It's The Vaccines Stupid!"

Part I: Evidence Linking Autism Rise in Children to Vaccinations

By F. William Engdahl

Global Research, September 05, 2014

https://www.globalresearch.ca/it-s-the-vaccines-stupid/15074

[...] The Food and Drug Administration considers vaccines safe but, just as with GMO, they have done no studies into the effects of multiple vaccinations as given in the common childhood series which started in the 1990s in the USA and spread to the UK and now across the EU.

According to Robert F. Kennedy, Jr., son of the late Attorney General and an attorney active in campaigning to expose mercury (Thimerosal) and other toxicity dangers in vaccines, recently stated, "as autism is a behavioral affliction rather than a precisely defined biological injury Ñ epidemiological studies are critical to establishing its causation. But the greatest source of epidemiological data is the Vaccine Safety Datalink (VSD) Ñ the government maintained medical records of hundreds of thousands of vaccinated children Ñ which Health and Human Services Department has gone to great lengths to keep out of the hands of plaintiffs' attorneys and independent scientistsÉThe raw data collected in the VSD would undoubtedly provide the epidemiological evidence needed to understand the relationship between vaccines and autism. The absence of such studies makes it easy for judges to say to plaintiffs they have not met their burden of proving causation."

Autism was virtually unknown in the United States until 1943 when it was diagnosed and identified eleven months after Thimerosal, a mercury-based vaccine "adjuvant" was first added to baby vaccines along with various aluminium compounds in the United States. Thimerosal is often used to stem fungi and bacterial growth in vaccines despite massive evidence of its severe effects as a potent neurotoxin. Following independent studies, Russia, Japan, Austria, Denmark, Sweden and Britain have banned Thimersol from childrens' vaccines. Germany to date has no such ban. The toxin was developed in 1930 by Eli Lilly. Tragically in 1991, despite overwhelming evidence to the contrary the US Government's Center for Disease Control (CDC), the same agency fuelling the current hysteria over the non-proven H1N1 Swine Flu virus danger, recommended that infants be injected with a series of mercury-containing vaccines in some cases within 24 hours of birth for Hepatitis B and two months for diphtheria-tetanus-pertussis.

Before 1989 US pre-school children received eleven vaccinations - polio, diphtheria-tetanus-pertussis, measles-mumps-rubella (MMR). By 1999, because of the various CDC recommendations, the number of vaccinations was twenty two before first grade of school. Parallel with this explosive rise in vaccinations of the very young in the United States, according to Kennedy, the rate of autism among children. The state of Iowa reported a 700% increase in autism in children beginning in the 1990's and along with California has banned mercury in vaccines. Despite evidence, however the US FDA continues to allow drug makers to include Thimerosal in numerous over-the-counter non-prescription medications as well as steroids and injected collagen. The US Government ships vaccines preserved with Thimerosal to numerous developing countries as well, where some are reporting sudden explosion of autism rates as well. In China, where autism was unknown before introduction of Thimerosal by US drug makers in 1999, press reports indicate there are almost two million autistic children.

Instances of autism in the US exploded as some 40 million children were injected during the 1990's with Thimersol-based vaccines, giving them unprecedented accumulations of mercury poison. The level of ethylmercury in a vaccine routinely given then to children of two months age was 99 times greater than the US Government's daily limit for exposure. As with the current WHO pandemic declaration around H1N1 Swine Flu, the CDC Vaccine Advisory Committee is filled with scientists with close ties to the pharmaceutical industry. Dr. Sam Katz, chairman of the committee was a paid consultant to most companies producing the vaccines he "recommended."

The aluminium danger remains

While vaccines available in the US today exist with no Thimerosal (50% mercury), virtually all vaccines still contain aluminum, which has been linked to impaired neurological development in children. Aluminum has not replaced thimerosal as a vaccine preservative; it has always been used in vaccines.

In the recent past, most US children got exposed to both thimerosal and aluminum simultaneously with the hepatitis B, Hib, DTaP (diphtheria, tetanus and pertussis) and pneumococcal vaccines. Combining mercury with aluminum increases the likelihood that the mercury will damage human tissue. [...]

(9) Dr. Andrew Wakefield, vaccine whistelblower, exonerated of charges that he conducted fraudulent tests

http://www.williamengdahl.com/englishNEO8June2016.php

What Media Hid in De Niro Autism Film Affair

By F. William Engdahl

8 June 2016

Dr. Andrew Wakefield, a former British gastro-enterologist and vaccine researcher has been fully exonerated of the charges that he, together with a world renowned pediatric gastroenterologist, Prof. John Walker-Smith, conducted fraudulent tests with children that raised the possibility of a link between the popular MMR (measles, mumps, rubella) vaccine and onset of autism and other severe symptoms. Most remarkable is the fact that despite his de facto exoneration in a British Court more than four years ago, in 2012, mainstream media in the UK and the USA have chosen to deliberately ignore the fact. They did so to hide the explosive content of WakefieldÕs film, Vaxxed. [...]

Despite the fact that Andrew WakefieldÕs Vaxxed was pulled at the last minute, Robert de Niro has done the world a great service, alone through the media firestorm the film has generated, by placing attention on the work of Wakefield and the urgent need for an international spotlight on possible links between vaccinations, especially the multiple MMR vaccine, and illnesses such as autism. Instead of shooting the messenger, Andrew Wakefield, honest journalism could discuss the content of the Wakefield documentary. ItÕs very sobering.

(10) Economist: More evidence that Autism is linked to Gut Bacteria

Antibiotics and MMR vaccines (or perhaps the preservative, or the Tylenol) change the gut bacteria. This article shows that The Economist, representing London bankers, is rejecting the Medical Establishment's theory that the cause of Autism is genetic, not environmental. But Wikipedia still adheres to the genetic theory. - Peter M.

https://www.economist.com/science-and-technology/2019/05/30/more-evidence-that-autism-is-linked-to-gut-bacteria

Autism-spectrum disorder

More evidence that autism is linked to gut bacteria

Understanding that link may be crucial to treatment

Print edition | Science and technology

May 30th 2019 | PHOENIX, ARIZONA

Paradigm shift is an overused term. Properly, it refers to a radical change of perspective on a topic, such as the move from the physics of Newton to the physics of Einstein, or the introduction of plate tectonics into geology. Such things are rare. Something which history may come to regard as a true paradigm shift does, however, seem to be going on at the moment in medicine. This is a recognition that the zillions of apparently non-pathogenic bacteria on and in human bodies, hitherto largely ignored, are actually important for people's health. They may even help to explain the development of some mysterious conditions.

One such condition is autism - these days often called autism-spectrum disorder (asd). asd is characterised by repetitive, stereotypical and often restricted behaviour such as head-nodding, and by the difficulties those with it have in reading the emotions of, and communicating with, other people. These symptoms are noticeable in children from the age of two onwards. Currently, in America, about one child in 59 is diagnosed with asd.

What causes asd has baffled psychiatrists and neurologists since the syndrome was first described, in the mid-20th century, by Hans Asperger and Leo Kanner. But the evidence is pointing towards the bacteria of the gut. That suggestion has been reinforced by two recently published studies - one on human beings and one on laboratory rodents.

Restoring the balance

The human study, the latest results of which came out a few weeks ago in Scientific Reports, is being conducted by Rosa Krajmalnik-Brown of Arizona State University and her associates. It was prompted by earlier work in which Dr Krajmalnik-Brown and James Adams, a colleague at Arizona State, sequenced the dna of gut bacteria from 20 autistic children to discover which species were present. They found that the children in their sample were missing hundreds of the thousand-plus bacterial species that colonise a "neurotypical" person's intestine. One notable absence was Prevotella. This bug, which makes its living by fermenting otherwise-indigestible carbohydrate polymers in dietary fibre, is abundant in the alimentary canals of farmers and hunter-gatherers in places like Africa, rare in western Europeans and Americans, and nearly nonexistent in children with asd.

Their discovery led Dr Krajmalnik-Brown and Dr Adams to the idea that restoring the missing bacteria might alleviate autism's symptoms. Two years ago they tested a process called microbiota transfer therapy (mtt) on 18 autistic children aged between seven and 16. Of their participants 15 were regarded, according to the Childhood Autism Rating Scale, as having "severe" autism.

mtt is a prolonged version of a process already used to treat infection by a bug called Clostridium difficile, which causes life-threatening diarrhoea. It involves transplanting carefully prepared doses of faecal bacteria from a healthy individual to a patient. The researchers gave the children, first, an oral antibiotic, a bowel cleanse and an oral antacid (to ensure that microbes administered by mouth would survive their passage through the stomach). They followed this up with either an oral or a rectal dose of gut bacteria, and then, for seven to eight weeks, a daily antacid-assisted oral dose.

Ten weeks after treatment started the children's Prevotella levels had multiplied 712-fold. In addition, those of another species, Bifidobacterium, had quadrupled. Bifidobacterium is what is known as a "probiotic" organism - something that acts as a keystone species in the alimentary ecosystem, keeping the mixture of gut bacteria healthy. Now, two years later, although levels of Prevotella have fallen back somewhat, they are still 84 times higher than they were before the experiment started. Levels of Bifidobacterium, meanwhile, have gone up still further - being five times higher than they had been at the beginning of the study. This, says Dr Krajmalnik-Brown, suggests the children's guts have become healthy environments that can recruit beneficial microbes by themselves.

Crucially, these changes in gut bacteria have translated into behavioural changes. Even 18 weeks after treatment started the children had begun showing reduced symptoms of autism. After two years, only three of them still rated as severe, while eight fell below the diagnostic cut-off point for asd altogether. These eight thus now count as neurotypical.

Exactly how gut bacteria might contribute to autism is a puzzle. But light has been shed on the matter by the second study, published this week in Cell by a team led by Sarkis Mazmanian of the California Institute of Technology. Dr Mazmanian and a group of colleagues that also included Dr Krajmalnik-Brown performed a type of mtt on mice. They collected bacteria from the faeces of both neurotypical and autistic people (who ranged in their symptoms from mild to severe) and transplanted these into hundreds of mice. They then interbred the recipient mice and studied the offspring of these crosses - animals that had picked up the transplanted bacteria from their mothers at birth.

Signal results

They were looking for the rodent equivalent of asd. And they found it. Most of the young mice harbouring gut bacteria from autistic human donors showed features of autism themselves. These included repetitive behaviours, reduced social and vocal communication with other mice, and restricted movement. In contrast, none of the mice colonised with bacteria from neurotypical people ended up autistic. Dr Mazmanian and his team discovered, moreover, that the intensity of a human donor's autism was transferred to the recipient mice. If an individual's symptoms were severe then so, too, were those of mice that hosted his gut bacteria.

Dr Mazmanian's study also dealt with the question of mechanism. One long-held suspicion is that a molecule called gamma-aminobutyric acid (gaba) is involved. gaba is a neurotransmitter, meaning that it carries signals between nerve cells. In particular, it counters the action of another neurotransmitter, glutamate, that excites nervous activity in the brain. Studies have shown that levels of gaba are lower than normal in the brains of autistic children (though, inexplicably, not in autistic adults). Some researchers suspect that this deficiency takes the brakes off glutamate's excitatory activity, thus stimulating things like repetitive behaviour.

Dr Mazmanian and his colleagues produced evidence supporting this idea. They collected faeces, blood and brain tissue from the rodents in the experiment. When they analysed these they found that the "autistic" animals were deficient in taurine and 5-aminovaleric acid, two substances that stimulate gaba's activity.

They, too, drew potentially therapeutic conclusions from their results, and tested those conclusions by giving the missing substances to female mice carrying autism-inducing bacteria in the weeks before those females become pregnant. The resulting offspring, though still showing some symptoms of autism, scored 30% better on the rating scale than did the offspring of untreated females.

Meanwhile, the success of the study in Arizona has prompted America's Food and Drug Administration (fda) to look into the matter. A firm called Finch Therapeutics Group, based in Massachusetts, hopes to commercialise the use of mtt as a treatment for autism and the fda has now granted this effort "fast track" status, which should speed up the review process. Dr Krajmalnik-Brown and Dr Adams are now recruiting volunteers for a large-scale trial of mtt for adults with autism, to see if they, too, can benefit. The paradigm, it seems, really is shifting. ==

Microbiota Transfer Therapy Gets Fast-Tracked for ASD Treatment

Steve Duffy

April 30, 2019

https://www.psychiatryadvisor.com/home/topics/autism-spectrum-disorders/microbiota-transfer-therapy-gets-fast-tracked-for-asd-treatment/

The Food and Drug Administration (FDA) has granted Fast Track status to the microbiota transfer therapy (MTT), Full-Spectrum Microbiota (FSM), for the treatment of children with autism spectrum disorder (ASD).

This article appeared in the Science and technology section of the print edition under the headline "Guts, brains and autism"

(11) CBC documentary about Autism: The Autism Enigma, presented by David Suzuki

The Autism Enigma

The Nature of Things with David Suzuki

Canadian Broadcasting Corporation

Review - Abstract

The purpose of this article is to introduce readers to a CBC documentary about a topical new research direction in autism ­ namely the possibility of a relationship between autism and bacteria in the gut. Key topics and controversies covered in the documentary are highlighted. Relevant background information, commentary, and references have been included to permit a critical perspective.

Autism has quickly changed from being a somewhat rare disorder to the most commonly identified developmental disability in the industrialized world. Since 1990, we have seen in North America an increase of about 600 per cent in children identified with autism (Hertz-Picciotto & Delwich, 2009; Suzuki, 2012). As of 2013, there are no accurate statistics on the prevalence of autism in Canada, though epidemiologi- cal research studies are underway (National Epidemiologic Database for the Study of Autism in Canada, 2012). In 2012, the prevalence in the United States was reported to be 1 in 88 based upon data collected between 2000­2008 (Centers for Disease Control and Prevention [CDC], 2012). A new National Interview Survey from the United States based on parent interviews is suggestive that the rate may be as high as 2% or 1 in 50 for children between 6 and 17 years of age, with boys being about four times as likely to be affected as girls (Blumberg et al., 2013). It has been argued that much of the prevalence increase since 2007 has been the result of diagnoses of children with previously unrecognized dis- order (Blumberg et al., 2013). Nevertheless, the finding of a rapid rise of autism diagnoses, particularly in certain popu- lations of new immigrants in certain geographical regions, strengthens the suspicion that there may be environmental causes (Barnevik-Olsson, Gillberg, & Fernell, 2010; Gruner & MacFabe, n.d.; Keen, Reid, & Arnone, 2010). [...]

The rest of this Review is at Autism-bacteria.pdf

You can watch The Autism Enigma at https://www.youtube.com/watch?v=53yzwWsBeAc

(12) CBC documentary shows Autism caused by harmful Bacteria in the gut

by Peter Myers, March 14, 2020

On Monday 27th August, 2012, Four Corners (on ABC TV in Australia) broadcast a documentary called "The Autism Enigma" which up-ended the conventional medical view that Autism is a genetic condition.

The program shows that Autism is caused by harmful Bacteria, and that overuse of Antibiotics, by killing off good Bacteria, can enable those harmful Bacteria to take over.

It was produced by the Canadian Broadcasting Corporation (CBC-TV), and presented by David Suzuki in his program The Nature of Things.

It features eminent Microbiologist Professor Sydney Finegold. He says, in an interview with Marion Gruner, that it might be possible to develop a vaccine "to totally prevent the disease and wipe it out": http://cogentbenger.com/autism/interviews/finegold-interview/

The challenge to orthodoxy arose not within Science or Medicine itself, but among distraught parents trying to help their afflicted children. They were assisted by dissident scientists not subservient to orthodoxy.

Some of the parents were migrants from Somalia. Their children back home were not developing Autism, but those in the West were ­ it could not be genetic.

In Somalia and Ethiopia, they were eating a lot of fermented foods, which may have protected them.

Autistic children are adversely affected by propionates (a common preservative) in foods.

You can watch The Autism Enigma at https://www.youtube.com/watch?v=53yzwWsBeAc

Since then, there has been more evidence assembled, eg 'Mental Health May Depend on Creatures in the Gut' - Scientific American: https://www.scientificamerican.com/article/mental-health-may-depend-on-creatures-in-the-gut/

But the medical establishment still peddles the 'genetic' theory of Autism.

Although the program does not deal with vaccines, the connection is that they can change the gut bacteria. The MMR Vaccine (or maybe just the Tylenol) may change the gut bacteria in genetically vulnerable children, leading to Autism. But the Cuban evidence shows that vaccination can be done safely - their way, not the Western / WHO way.

Contrary to the usual view that Science is monolithic, scientists in all domains are bitterly divided, have heated arguments, disparage one another, and even refuse to speak to one another. The Peer Review system allows one faction to gain power at the top of the tree, and to impose an Inquisition on those who disagree.

In addition, industries can capture their regulator. Eg Boeing captured the FAA, Big Pharma has captured the FDA, and the 5G companies have captured the Electromagnetic regulator.

END

Copyright: Peter Myers asserts the right to be identified as the author of the material written by him on this website, being material that is not otherwise attributed to another author.

END

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